Development of targeted safety hazard management plans utilizing multidimensional association rule mining.

Investigating hidden hazards and implementing closed-loop management are essential strategies for accident prevention in the mining industry. This study tackles a key challenge in applying association rule mining to the development of hazard management plans for underground mines. The current approach mainly focuses on hazard description data, often underutilizing critical information such as hazard time and location.

Photoelectron Imaging Spectroscopic and Geometric Configuration and Chemical Bond Analysis of Rh(CN) ( = 1-3) Clusters.

We obtained the photoelectron spectra of Rh(CN) using the negative ion photoelectron velocity-map imaging (NI-PEVMI) technique and revealed the photodesorption process of Rh(CN). The vertical detachment energy (VDE) and adiabatic detachment energy (ADE) of Rh(CN) have both been experimentally reported to be 2.04 (3) eV.

Achieving Bright Luminescence and X-ray Scintillation in Zero-Dimensional Cesium Zinc Bromides by Cu-Mn Codoping.

Zero-dimensional (0D) metal halides have emerged as excellent luminescent materials for optical and optoelectronic applications. Especially environmentally friendly ternary zinc halides have recently drawn increasing attention. Herein, we present the codoping of Cu and Mn ions into 0D CsZnBr single crystals (SCs), which show bright PL emission and high stability.

Neonicotinoid metabolites in farmland surface soils in China based on multiple agricultural influencing factors: A national survey.

Certain neonicotinoid metabolites (mNEOs) are causing widespread concern because they are equally or even more toxic than the parent NEOs. Currently, there is limited information on the distribution of mNEOs in soil. Especially, it is unknown that the effects of agricultural factors, such as plastic filming, plowing, irrigation, and fertilization, on mNEOs.

Pollution characteristics, environmental issues, and green development of neonicotinoid insecticides in China: Insights from Imidacloprid.

Imidacloprid (IMI), a leading neonicotinoid insecticide, is widely used in China. Nevertheless, owing to its high toxicity to pollinators, regulatory scrutiny of its usage has increased in recent years. Despite this, no relevant issues have been announced in China, and its usage continues to rise.

Significant effects of bioavailable heavy metals on antibiotic resistome in paddy soils as revealed by metagenomic analysis.

Heavy metals (HMs) act as a long-term selective pressure for the emergence and maintenance of antibiotic resistance genes (ARGs) in agricultural soils. However, the effects of HMs on ARG distributions in paddy soils and the underlying mechanisms remain unclear. In this study, 74 soil samples were collected from the paddy fields to explore the impact of HMs on ARG profiles.

Integrative multi-omics analysis of Crohn's disease and metabolic syndrome: Unveiling the underlying molecular mechanisms of comorbidity.

Objectives: The focus of this study is on identifying a potential association between Crohn's disease (CD), a chronic inflammatory bowel condition, and metabolic syndrome (Mets), characterized by a cluster of metabolic abnormalities, including high blood pressure, abnormal lipid levels, and overweight. While the link between CD and MetS has been suggested in the medical community, the underlying molecular mechanisms remain largely unexplored.

Methods: Using microarray data from the Gene Expression Omnibus (GEO) database, we conducted a differential gene expression analysis and applied Weighted Gene Co-expression Network Analysis (WGCNA) to identify genes shared between CD and MetS.

Enhancing physician support in pancreatic cancer diagnosis: New M-F-RCNN artificial intelligence model using endoscopic ultrasound.

Endoscopic ultrasound (EUS) is vital for early pancreatic cancer diagnosis. Advances in artificial intelligence (AI), especially deep learning, have improved medical image analysis. We developed and validated the Modified Faster R-CNN (M-F-RCNN), an AI algorithm using EUS images to assist in diagnosing pancreatic cancer.

Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss.

Objectives: To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) in patients with refractory sudden sensorineural hearing loss (SSNHL).

Material And Methods: Thirty patients with refractory SSNHL were treated with intratympanic methylprednisolone perfusion (IMP) for 10 days. Expression of HIF-1α and histone deacetylase 2 (HDAC2) was evaluated in peripheral blood mononuclear cells (PBMCs) and .

mC related-regulator-mediated methylation modification patterns and prognostic significance in breast cancer.

5-Methylcytosine (mC) is closely associated with cancer. However, the role of mC in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen mC regulators associated with BC progression and analyze their clinical values.

A Standardized Mouse Model for Wound Infection with .

is a highly drug-resistant pathogen known to impair wound healing and provoke inflammatory responses, potentially leading to immune dysregulation. This study aimed to systematically investigate the immune response mechanisms mediated by cytokines following infection through the development of a standardized wound model. Kunming mice were selected as experimental subjects and given 8 mm diameter lesions on their backs and inoculated with standard strains PAO1 and PA14.

Scaling of the formation of cyclodextrin-based droplets in a flow-focusing microchannel.

Cyclodextrin (CD)-based droplets have received considerable attention in health and body care applications, and a real-time approach to actively control the size and generation frequency of the droplets is desirable. Here we study the droplet formation experimentally inside a flow-focusing microchannel using aqueous CD solutions as the continuous phase, and different oils including glycerol trioleate (TG), oleic acid (OA) and tetradecane (TD) as the dispersed phase, respectively. We identify three distinct flow regimes: threading, dripping and jamming, whose boundaries change as the oil is varied.

Do types of social isolation affect post-traumatic growth outcomes differently in patients undergoing hemodialysis? A moderated chain mediation model.

Aims: The present study aimed to explore the effect of different types of social isolation on post-traumatic growth (PTG) and its underlying mediating and moderating mechanisms.

Methods: This cross-sectional study recruited 274 patients undergoing hemodialysis between October and November 2022. Structural equation modeling was used to test the proposed relationships.

Effect of a reduced arterial axial pre-stretch ratio during aging on the cardiac output and cerebral blood flow in the healthy elders.

Background And Objective: It is an indisputable physiological phenomenon that the arterial axial pre-stretch ratio (AAPSR) decreases with age, but little attention has been paid to the effect of this reduction on chronic diseases during aging.

Methods: Here we reported an experimental method to simulate arteries aging, developed a fluid-structure interaction model with the effect of AAPSR changes, and compared it with the anatomy data and structural parameters of the human thoracic aorta.

Results: We showed that with the process of aging, the decrease of AAPSR leads to a decline of arterial elasticity, a decrease of arterial elastic strain energy, which weakens the ability to promote blood circulation, the corresponding decrease in cardiac output (CO) and cerebral blood flow (CBF) causes distal organ and body tissue ischemia, which is one of the main causes of increased blood pressure and decreased cerebral perfusion in the elderly.

Acupuncture for Aromatase Inhibitor-Induced Arthralgia in Breast Cancer: An Umbrella Review.

Background: Acupuncture therapy shows promise in managing aromatase inhibitor-induced arthralgia (AIA) among breast cancer patients. An umbrella review synthesizes findings from systematic reviews and meta-analyses (SRs/MAs) to assess its effectiveness.

Summary: This umbrella review aimed to evaluate the effectiveness of acupuncture therapy in treating AIA among breast cancer patients by analyzing existing evidence from SRs/MAs.

Increased CD14HLA-DR myeloid-derived suppressor cells can be regarded as a biomarker on disease severity and response to therapy in acute coronary syndrome.

Purpose: This study aimed to investigate the dynamic changes in monocytic myeloid-derived suppressor cells (M-MDSCs) and their implications in the pathogenesis of acute coronary syndrome (ACS), shedding light on potential therapeutic targets.

Experimental Design: Peripheral blood samples were collected from 68 ACS patients, 35 stable angina pectoris (SAP) patients, and 30 healthy controls (HC). Multi-parameter flow cytometry was employed for analysis of M-MDSCs, explored with disease characteristics and progression.

Hinokiflavone from Platycladi cacumen as a potent broad-spectrum inhibitor of gut microbial Loop-1 β-glucuronidases: Inhibition kinetics and molecular simulation.

Gut microbial Loop-1 β-glucuronidases (gmGUS) played an important role in irinotecan-induced gastrointestinal toxicity by regulating the level of its active metabolite SN38 through enterohepatic recirculation. gmGUS inhibition has emerged as a promising approach to relieve its dose-limiting intestinal toxicity and improve its medication efficacy. This study aims to investigate the inhibitory effects and mechanisms of Platycladi cacumen and its main constituent hinokiflavone against four different types of Loop-1 gmGUS (EeGUS, SaGUS, CpGUS and EcGUS).

Effect of body orientation and joint movement on local bioimpedance measurements.

The purpose of this pilot study was to determine if body orientation, skin treatment, joint angle, and shoulder arch movements affect localized bioimpedance spectroscopy (BIS) measurement. Nowadays, there are various wearable and portable impedance measurement tools in different shapes and sizes. Therefore, the body position and orientation of the subject during measurement may be of great importance for the comparability of the results.

SPLHRNMTF: robust orthogonal non-negative matrix tri-factorization with self-paced learning and dual hypergraph regularization for predicting miRNA-disease associations.

MicroRNAs (miRNAs) have been demonstrated to be closely related to human diseases. Studying the potential associations between miRNAs and diseases contributes to our understanding of disease pathogenic mechanisms. As traditional biological experiments are costly and time-consuming, computational models can be considered as effective complementary tools.

Redox-Active Polyaniline Covalently grafted Black Phosphorus Nanosheets for Integrated Digital-Analogue Memristors.

Surface covalent modification of black phosphorus (BP) with organic polymers represents a promising strategy to enhance its stability and tailor its electronic properties. Despite this potential, developing memristive materials through suitable polymer structures, grafting pathways, and polymerization techniques remains challenging. In this study, polyaniline (PANI)-covalently grafted black phosphorus nanosheets (BPNS) are successfully prepared with redox functionalities via the in situ polymerization of aniline on the surface of 4-aminobenzene-modified BPNS.