Biological aging mediates the association between volatile organic compounds and cardiovascular disease.

Background: Evidence for the relationship between individual and combined volatile organic compounds (VOCs) and cardiovascular disease (CVD) is limited. Besides, the mediating role of biological aging (BA) has not been studied. Therefore, this study aimed to examine the association between VOCs and CVD risk and to explore the mediating effects of BA.

SLC7A9 suppression increases chemosensitivity by inducing ferroptosis via the inhibition of cystine transport in gastric cancer.

Background: SLC7A9 is responsible for the exchange of dibasic amino acids and cystine (influx) for neutral amino acids (efflux). Cystine/cysteine transport is related to ferroptosis.

Methods: Sanger sequencing detected TP53 status of cancer cells.

Effects of structural parameters of pressure-swirl nozzle on atomization and dust removal characteristics.

To further improve the dust removal efficiency of water spray, the influence of key structure parameters of nozzle on atomization characteristic (droplet size, atomization angle, flow rate, effective spray distance, wind disturbance resistance) was studied. The results showed that the nozzle had good atomization performance when the outlet diameter was 1.5 mm.

Genome‑based classification of the family Natrialbaceae and description of four novel halophilic archaea from three saline lakes and a saline-alkaline land.

The current representatives of the family Natrialbaceae within the class Halobacteria were subjected to phylogenetic, phylogenomic, and comparative genomic analyses. The current species of Halobiforma and Halomontanus were found to be related to those of Natronobacterium and Natronoglomus, respectively. According to the cutoff value of average amino acid identity (AAI) (≤ 76%) proposed to differentiate genera within the family Natrialbaceae, Halobiforma, and Natronoglomus should be merged with Natronobacterium and Halomontanus, respectively.

Structure modification and luminescence regulation in new violet light excitable SrBaYLa(SiO)O:Eu phosphors cation substitution.

Cyan-emitting phosphors are urgently needed to address the "cyan gap" in artificial full-spectrum lighting. In this research, a series of SrBaYLa(SiO)O:Eu (0.005 ≤ ≤ 0.

Shared Genetic Architecture and Causal Relationship between Serum 25-Hydroxyvitamin D and Bone Mineral Density.

Background: Despite the well-established regulatory role of vitamin D in maintaining bone health, little is known about the shared genetics and causality of the association between serum 25-hydroxyvitamin D (25OHD) and bone mineral density (BMD).

Methods: Leveraging individual-level data from the UK Biobank (UKB) cohort and summary-level data from the genome-wide association studies (GWASs) conducted on European individuals for serum 25OHD (N = 417,580) and estimated heel BMD (eBMD, N = 426,824), we systematically elucidated the shared genetic architecture underlying serum 25OHD and eBMD through a comprehensive genome-wide cross-trait design.

Results: Despite a lack of global genetic correlation (rg = -0.

Using the GoogLeNet deep-learning model to distinguish between benign and malignant breast masses based on conventional ultrasound: a systematic review and meta-analysis.

Background: Breast cancer is one of the most common malignancies in women worldwide, and early and accurate diagnosis is crucial for improving treatment outcomes. Conventional ultrasound (CUS) is a widely used screening method for breast cancer; however, the subjective nature of interpreting the results can lead to diagnostic errors. The current study sought to estimate the effectiveness of using a GoogLeNet deep-learning convolutional neural network (CNN) model to identify benign and malignant breast masses based on CUS.

Switchable Photovoltaic Effect and Robust Nonlinear Optical Response in a High-Temperature Molecular Ferroelectric [CNH][PbI].

Hybrid organic-inorganic molecular ferroelectrics (HOIMFs) have garnered significant attention for their potential applications in nonvolatile memory and spintronic devices. However, few efforts have been devoted to the photoelectric properties of lead halide molecular ferroelectrics, despite the fact that robust ferroelectricity and flexibility are desirable for thin-film photoelectric devices. Herein, we present a novel lead halide molecular ferroelectric [CNH][PbI] () synthesized hydrothermally.

Study on sentinel hosts for surveillance of future COVID-19-like outbreaks.

The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host.

Molecular insights into the binding mechanism of strontium and cesium on phyllosilicates with different expandability.

The environmental fate of strontium (Sr) and cesium (Cs), as the critical radioactive fission products, have raised significant concerns regarding radioactive waste disposal and environmental protection. The current study investigated the distinction in the binding configurations of Sr and Cs on various 2:1 phyllosilicate (illite, vermiculite, and montmorillonite) by combining batch adsorption, sequential extraction, and spectroscopic analyses. The results show that strontium adsorption is strongly influenced by pH as well as ionic strength, while there is no significant variability in strontium adsorption by different types of clay minerals.

The selective occurrence of ripening effect makes the cotransport of various sized nanoplastics in seawater-saturated and freshwater-saturated porous media significantly different.

We explored the coadsorption and cotransport (single, binary, and ternary systems) of varying sized (50, 200, and 500 nm) Polymethylmethacrylate (PMMA) nanoplastics (NPs) with different concentration ratios in freshwater-saturated and seawater-saturated porous media. It was found that ripening effect occurred selectively, with ripening more likely to occur in seawater relative to freshwater, resulting in significantly different cotransport and coadsorption of varying sized NPs in freshwater-saturated and seawater-saturated porous media. In freshwater, there was no obvious ripening effect happening.

Breathable and Stretchable Epidermal Electronics for Health Management: Recent Advances and Challenges.

Advanced epidermal electronic devices, capable of real-time monitoring of physical, physiological, and biochemical signals and administering appropriate therapeutics, are revolutionizing personalized healthcare technology. However, conventional portable electronic devices are predominantly constructed from impermeable and rigid materials, which thus leads to the mechanical and biochemical disparities between the devices and human tissues, resulting in skin irritation, tissue damage, compromised signal-to-noise ratio (SNR), and limited operational lifespans. To address these limitations, a new generation of wearable on-skin electronics built on stretchable and porous substrates has emerged.

Nomogram for prediction of severe postoperative complications in elective hepato-pancreato-biliary surgery after COVID-19 breakthrough infection: A large multicenter study.

Background: Currently, there is a deficiency in a strong risk prediction framework for precisely evaluating the likelihood of severe postoperative complications in patients undergoing elective hepato-pancreato-biliary surgery subsequent to experiencing breakthrough infection of coronavirus disease 2019 (COVID-19). This study aimed to find factors predicting postoperative complications and construct an innovative nomogram to pinpoint patients who were susceptible to developing severe complications following breakthrough infection of COVID-19 after undergoing elective hepato-pancreato-biliary surgery.

Methods: This multicenter retrospective cohort study included consecutive patients who underwent elective hepato-pancreato-biliary surgeries between January 3 and April 1, 2023 from four hospitals in China.

Evaluation of Female Recipient Infertility and Donor Spermatogonial Purification for Germ Cell Transplantation in .

Since the advent of germ cell transplantation (GCT), it has been widely used in shortening the fish breeding cycle, sex-controlled breeding and the protection of rare and endangered fish. In this study, the effectiveness of female sterile recipient preparation and donor stem cell isolation and purification were comprehensively evaluated for spermatogonial stem cell transplantation (SSCT) in . The best way to prepare sterile recipients was found to be giving three-year-old fish four intraovarian injections of busulfan (20 mg/kg body weight) combined with exposure to a high temperature (28 °C) after the spawning season compared with the two other ways, which induced apoptosis of most of the endogenous germ cells, resulting in shrinkage of the spawning plate and enlargement of the ovarian lumen.

The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging.

Aging is usually accompanied by excessive body fat gain, leading to increased susceptibility to comorbidities. This study aimed to explore an unexpected function for the eukaryotic initiation factor-2α (eIF2α) during aging. Reducing the eIF2α dose led to a reconfiguration of the metabolic equilibrium, promoting catabolism, facilitating lipolysis, and decreasing body fat accumulation while maintaining healthy glucose and lipid metabolism during aging.

Effects of tire wear particle on growth, extracellular polymeric substance production and oxidation stress of algae Chlorella vulgaris: Performance and mechanism.

Tire wear particles (TWP) represent a distinctive form of microplastics (MPs) that are widely distributed in aquatic ecosystems. However, the toxicity of various types of TWP on phytoplankton remain to be further explored. Thus, three different TWPs originating from replaced bicycle, car, and electro-mobile tire (marked as BTWP, CTWP, and ETWP) were selected and their long-term biological influences on Chlorella vulgaris were investigated.

Kilowatt-level supercontinuum generation employing a homemade taper-shaped ytterbium-doped fiber amplifier.

A simple generation method of high-power supercontinuum (SC) based on a homemade long ytterbium-doped taper fiber (T-YDF) amplifier has been demonstrated experimentally and analyzed in this work. The power and spectra of the obtained SC are made adjustable by changing the seed pulse repetition rates. Under a 7.

Loureirin hydrogel promotes healing of radionuclide-contaminated wounds by regulating angiogenesis and immune cells.

Radionuclide-contaminated wounds face clinical dilemmas such as repeated erosion and ulceration and are difficult to heal. In this work, we aimed to develop a biodegradable hydrogel with a beneficial effect on radionuclide-contaminated wounds and initially investigated the mechanism of action of the hydrogel. The hydrogel was produced through the ring-opening polymerization of polycaprolactone (PCL) triggered by polyethylene glycol (PEG), and its physicochemical properties were characterized by gel permeation chromatography, nuclear magnetic resonance, rheological properties testing, and other techniques.