Development and Evaluation of Machine Learning Models for the Detection of Emergency Department Patients with Opioid Misuse from Clinical Notes.

Objectives: The accurate identification of Emergency Department (ED) encounters involving opioid misuse is critical for health services, research, and surveillance. We sought to develop natural language processing (NLP)-based models for the detection of ED encounters involving opioid misuse.

Methods: A sample of ED encounters enriched for opioid misuse was manually annotated and clinical notes extracted.

OVME-REG: Harris hawks optimization algorithm based optimized variational mode extraction for eye blink artifact removal from EEG signal.

The electroencephalogram (EEG) recordings from the human brain are useful for detecting various brain syndromes. These recordings are typically contaminated by high amplitude eye blink artifacts, which leads to deliberate misinterpretation of the EEG signal. Recently, variational mode extraction (VME) has been used to detect eye blink artifacts.

A Nonlinear Functional Link Multilayer Perceptron Using Volterra Series as an Adaptive Noise Canceler for the Extraction of Fetal Electrocardiogram.

Uninterrupted monitoring of fetal cardiac health is essential for the timely diagnosis of congenital diseases. The maternal Electrocardiogram (mECG), which has the most significant impact, always tampers with the signals collected from the pregnant woman's abdomen. So, an efficient nonlinear filtering network based on artificial neural network (ANN) is required to eliminate the maternal part from the abdominal Electrocardiogram (aECG) that is traveled from the thoracic of the mother to the abdomen following nonlinear dynamics.

Anisotropic Superconducting Nb CT MXene Processed by Atomic Exchange at the Wafer Scale.

Superconductivty has recently been induced in MXenes through surface modification. However, the previous reports have mostly been based on powders or cold-pressed pellets, with no known reports on the intrinsic superconsucting properties of MXenes at the nanoale. Here, it is developed a high-temperature atomic exchange process in NH atmosphere which induces superconductivity in either singleflakes or thin films of Nb CT MXene.

Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability.

Submaximal exercise capacity is an indicator of cardiorespiratory fitness with clinical and public health implications. Submaximal exercise capacity and its response to exercise programs are characterized by heritability levels of about 40%. Using physical working capacity (power output) at a heart rate of 150 beats/min (PWC150) as an indicator of submaximal exercise capacity in subjects of the HERITAGE Family Study, we have undertaken multi-omics and in silico explorations of the underlying biology of PWC150 and its response to 20 wk of endurance training.

Deficiency in the omega-3 lysolipid transporter Mfsd2a leads to aberrant oligodendrocyte lineage development and hypomyelination.

Patients with autosomal recessive microcephaly 15 caused by deficiency in the sodium-dependent lysophosphatidylcholine (LPC) transporter major facilitator superfamily domain-containing 2a (Mfsd2a) present with both microcephaly and hypomyelination, suggesting an important role for LPC uptake by oligodendrocytes in the process of myelination. Here we demonstrate that Mfsd2a is specifically expressed in oligodendrocyte precursor cells (OPCs) and is critical for oligodendrocyte development. Single-cell sequencing of the oligodendrocyte lineage revealed that OPCs from OPC-specific Mfsd2a-KO mice (2aOKO mice) underwent precocious differentiation into immature oligodendrocytes and impaired maturation into myelinating oligodendrocytes, correlating with postnatal brain hypomyelination.

Large-Area Metal-Semiconductor Heterojunctions Realized via MXene-Induced Two-Dimensional Surface Polarization.

Direct MXene deposition on large-area 2D semiconductor surfaces can provide design versatility for the fabrication of MXene-based electronic devices (MXetronics). However, it is challenging to deposit highly uniform wafer-scale hydrophilic MXene films (e.g.

Exploring the versatility of pentafulvene-maleimide cycloaddition as a ligation strategy: buffer and pH effects.

Ligation chemistries are often required to perform under stringent conditions that preserve the integrity and function of (bio)conjugates, including specific biological buffers. To explore the versatility of the pentafulvene-maleimide ligation for (bio)conjugations, we studied the stability of the coupling partners and their Diels-Alder cycloaddition (DAC) in buffers used commonly in biological assays, protein chemistry and bioconjugates. The stability of 6,6-dialkylpentafulvene and maleimide derivatives to a panel of buffers with pH values between 3.

Growth of 2D Materials at the Wafer Scale.

Wafer-scale growth has become a critical bottleneck for scaling up applications of van der Waal (vdW) layered 2D materials in high-end electronics and optoelectronics. Most vdW 2D materials are initially obtained through top-down synthesis methods, such as exfoliation, which can only prepare small flakes on a micrometer scale. Bottom-up growth can enable 2D flake growth over a large area.

High-Yield Ti C T MXene-MoS Integrated Circuits.

It is very challenging to employ solution-processed conducting films in large-area ultrathin nanoelectronics. Here, spray-coated Ti C T MXene films as metal contacts are successfully integrated into sub-10 nm gate oxide 2D MoS transistor circuits. Ti C T films are spray coated on glass substrates followed by vacuum annealing.

All-Solution-Processed Quantum Dot Electrical Double-Layer Transistors Enhanced by Surface Charges of TiCT MXene Contacts.

Fully solution-processed, large-area, electrical double-layer transistors (EDLTs) are presented by employing lead sulfide (PbS) colloidal quantum dots (CQDs) as active channels and TiCT MXene as electrical contacts (including gate, source, and drain). The MXene contacts are successfully patterned by standard photolithography and plasma-etch techniques and integrated with CQD films. The large surface area of CQD film channels is effectively gated by ionic gel, resulting in high performance EDLT devices.

Iontronics Using VCT MXene-Derived Metal-Organic Framework Solid Electrolytes.

Electronic applications of porous metal-organic frameworks (MOFs) have recently emerged as an important research area. However, there is still no report on using MOF solid electrolytes in iontronics, which could take advantage of the porous feature of MOFs in the ionic transport. In this article, MXene-derived two-dimensional porphyrinic MOF (MX-MOF) films are demonstrated as an electronic-grade proton-conducting electrolyte.

PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease.

Guanabenz (GBZ), an α-adrenergic agonist, demonstrated off-target effects that restored protein homeostasis and ameliorated pathobiology in experimental models of neurodegenerative disease. However, GBZ did not directly activate the integrated stress response (ISR), and its proposed mode of action remains controversial. Utilizing an iterative screen of over 10,000 GBZ analogues, we analyzed 432 representative compounds for cytotoxicity in Wild-type, PPP1R15A-/-, and PPP1R15B-/- mouse embryonic fibroblasts.

Neural crest-specific deletion of in mice leads to craniofacial abnormalities including cleft palate.

Alternative splicing (AS) creates proteomic diversity from a limited size genome by generating numerous transcripts from a single protein-coding gene. Tissue-specific regulators of AS are essential components of the gene regulatory network, required for normal cellular function, tissue patterning, and embryonic development. However, their cell-autonomous function in neural crest development has not been explored.

Integration of Electrochemical Microsupercapacitors with Thin Film Electronics for On-Chip Energy Storage.

The development of self-powered electronic systems requires integration of on-chip energy-storage units to interface with various types of energy harvesters, which are intermittent by nature. Most studies have involved on-chip electrochemical microsupercapacitors that have been interfaced with energy harvesters through bulky Si-based rectifiers that are difficult to integrate. This study demonstrates transistor-level integration of electrochemical microsupercapacitors and thin film transistor rectifiers.

Correction: Bone marrow MSCs in MDS: contribution towards dysfunctional hematopoiesis and potential targets for disease response to hypomethylating therapy.

In the original version of this article there was a mistake in the spelling of the author Sujoy Ghosh, originally spelt Sujoy Gosh. This has now been corrected in both the PDF and HTML versions of the article.

Exploring the underlying biology of intrinsic cardiorespiratory fitness through integrative analysis of genomic variants and muscle gene expression profiling.

Intrinsic cardiorespiratory fitness (CRF) is defined as the level of CRF in the sedentary state. There are large individual differences in intrinsic CRF among sedentary adults. The physiology of variability in CRF has received much attention, but little is known about the genetic and molecular mechanisms that impact intrinsic CRF.

Bone marrow MSCs in MDS: contribution towards dysfunctional hematopoiesis and potential targets for disease response to hypomethylating therapy.

The study of myelodysplastic syndromes (MDS) in murine models has now indicated the possible involvement of the bone marrow microenvironment in the generation of dysplastic hematopoietic cells. However, there is scant work on patient samples and the role of hypomethylating agents on the bone marrow stromal cells of MDS patients is unclear. We show that human MDS-MSCs exhibit phenotypic, transcriptomic and epigenetic abnormalities.

Transparent Electronics Using One Binary Oxide for All Transistor Layers.

A novel process is developed in which thin film transistors (TFTs) comprising one binary oxide for all transistor layers (gate, source/drain, semiconductor channel, and dielectric) are fabricated in a single deposition system at low temperature. By simply changing the flow ratio of two chemical precursors, C H HfN and (C H ) Zn, in an atomic layer deposition system, the electronic properties of the binary oxide (Hf Zn O or HZO) are tuned from conducting, to semiconducting, to insulating. Furthermore, by carefully optimizing the properties of the various transistor HZO layers, all-HZO thin film transistors are achieved with excellent performance on both glass and plastic substrates.

Transparent Flash Memory Using Single TaO Layer for Both Charge-Trapping and Tunneling Dielectrics.

We report reproducible multibit transparent flash memory in which a single solution-derived TaO layer is used simultaneously as a charge-trapping layer and a tunneling layer. This is different from conventional flash memory cells where two different dielectric layers are typically used. Under optimized programming/erasing operations, the memory device shows excellent programmable memory characteristics with a maximum memory window of ∼10.

Switching mechanism in Au nanodot-embedded Nb2O5 memristors.

Resistive switching behavior of Au nanodot-embedded Nb2O5 memristor devices is reported. Due to controlled formation and/or rupture of conductive filaments; Au nanodot-embedded Nb2O5 devices show better consistency during transition from high to low resistance state and vice-versa. The memristive transition is explained using a physical model which involves oxygen ion, O(2-) trapping or detrapping at the metal-oxide interface, and O(2-) transport and annihilation with the oxygen vacancies in the breakdown percolation path.

Improvement in protein-coding region identification based on sliding window trigonometric fast transforms using singular value decomposition.

In this paper, the performance of various sliding window trigonometric fast transforms for identification of protein coding regions has been analysed at the nucleotide level. It is found that, Short-Time Discrete Fourier Transform (ST-DFT) gives better identification accuracy in comparison with Short-Time Discrete Cosine Transform (ST-DCT), Short-Time Discrete Sine Transform (ST-DST) and Short-Time Discrete Hartley Transform (ST-DHT). In the proposed method, identification accuracy of protein coding regions has been improved by applying Singular Value Decomposition (SVD) on the DNA spectrum obtained using sliding window trigonometric fast transforms.

Identification of protein-coding regions using Modified Gabor-Wavelet Transform with Signal Boosting Technique.

Modified Gabor-Wavelet Transform (MGWT) has been previously used for identification of protein coding regions. This method does not significantly suppress the non-coding regions which may result incorrect identification. To enhance the discrimination between the coding and non-coding regions of the DNA sequence, Signal Boosting Technique (SBT) is applied on the projection coefficients which are obtained by applying MGWT.