Publications by authors named "Hossein Naddafnia"

Article Synopsis
  • Hearing loss is a prevalent issue in Iran, particularly autosomal recessive non-syndromic hearing loss (ARNSHL), which has over 70 identified genetic causes and is influenced by high rates of familial marriage.
  • A study used whole exome sequencing (WES) on eight severe cases of nonsyndromic hearing loss, revealing 10 mutations across 7 different genes, with seven unique mutations found in seven families.
  • The study concluded that WES effectively identified causal mutations in ARNSHL cases, suggesting that broader meta-analyses could help pinpoint common mutations linked to deafness in various populations.
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Background: In the present study, we investigate the prevalence of the GJB2 gene mutations, and deletions in the GJB6 gene, namely del (GJB6-D13S1830) and del (GJB6-D13S1854), in patients with autosomal recessive non-syndromic hearing loss (ARNSHL) from the central region of Iran.

Methods: One hundred and thirty-one unrelated ARNSHL cases from the central part of Iran were recruited. Among them, 81% (106 cases) had at least two affected relatives.

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Disseminated intravascular coagulation is a pathologic syndrome with different medical disorders. Diagnosis and treatment of this syndrome is one of the difficult managements in medical science. Thromboelastogram is the only guide for early diagnosis and precise management of this syndrome.

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Unlabelled: The finger plethysmographic waveform of pulse oximeters is a qualitative indicator of fingertip perfusion. This waveform has been used to assess the depth of anesthesia. Its cyclical changes associated with mechanical ventilation have also been used to detect changes in blood volume under normotensive conditions and has revealed that minimal normotensive hypovolemia can cause a significant increase in the delta-down component of this waveform.

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