Prevalence of Plasmid-Mediated Quinolone Resistance Genes in Isolates From Colonic Biopsies of Iranian Patients With Inflammatory Bowel Diseases: A Cross-Sectional Study.

Background And Aims: Emerging evidence suggests that ciprofloxacin and other quinolones can be effectively used as adjuncts to immunosuppressive therapy in managing inflammatory bowel disease (IBD). Clinical isolates of Enterobacterales frequently exhibit quinolone resistance. Additionally, increased IBD severity has been linked to the proliferation of Enterobacterales in the gut.

Green solvent-based extraction of cellulose from hemp bast fibers: From treatment efficacy to characterizations and optimization.

This study assessed the efficacy of deep eutectic solvents (DESs) as green solvents for cellulose extraction from hemp bast fiber. Three DES mixtures were applied, and the combination of choline chloride and glycerol was selected for further experimentation due to its superior performance. The impact of four key parameters- treatment time, treatment temperature, DES-to-hemp ratio, and glycerol-to-choline chloride ratio was analyzed using Central-Composite Design (CCD) within response surface methodology (RSM) to optimize cellulose extraction.

Hydrophilic Metal-Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery.

For bridging the gap between biological and synthetic materials, the fusion of Metal-Organic Frameworks (MOFs) with biological entities has emerged as a revolutionary strategy in functional materials. In this context, our study introduces a novel structure wherein Bovine Serum Albumin (BSA), a robust and versatile protein, encapsulates zeolitic imidazolate framework-8 (ZIF-8), forming a protein-caged MOF. Highlighting the advantages of this innovative design, the protein-encapsulation enhances the stability and dispersity of ZIF-8, and aids in the synthesis of smaller-sized nanoparticles, crucial for size-impact performance applications.

Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications.

Antimicrobial resistance is a significant global public health issue, and the dissemination of antibiotic resistance in Gram-positive bacterial pathogens has significantly increased morbidity, mortality rates, and healthcare costs. Among them, Staphylococcus, especially methicillin-resistant Staphylococcus aureus (MRSA), causes a wide range of diseases due to its diverse pathogenic factors and infection strategies. These bacteria also present significant issues in veterinary medicine and food safety.

Enhanced adsorption of toluene on thermally activated ZIF-67: Characterization, performance, and modeling insights.

The zeolitic imidazolate framework-67 (ZIF-67) has been explored for the dynamic adsorption of toluene vapor. We synthesized ZIF-67 through a straightforward room-temperature process and characterized it using XRD, FT-IR, DLS, and SEM techniques. The synthesized ZIF-67 possessed a Brunauer-Emmett-Teller (BET) surface area of 1578.

Effects of non-tuberculous mycobacteria on BCG vaccine efficacy: A narrative review.

The bacterial pathogen is responsible for the ongoing global tuberculosis (TB) epidemic. Bacille Calmette-Guérin (BCG), the only currently approved TB vaccine, is successful in preventing disseminated disease in newborns. However, it has a variable efficacy against pulmonary TB in adults.

Antimicrobial combination effects against multidrug-resistant and strains: A cross-sectional study.

Background And Aims: Emergence of multidrug resistance in non-fermenting Gram-negative bacilli is a threat to public health. Combination therapy is a strategy for the treatment of antibiotic-resistant infections.

Methods: In this cross-sectional study, a total of 63 nonduplicate clinical isolates of and  were collected from various specimens.

Epidemiology of first- and second-line drugs-resistant pulmonary tuberculosis in Iran: Systematic review and meta-analysis.

Drug resistance among (MTB) strains is a growing concern in developing countries. We conducted a comprehensive search for relevant studies in Iran on PubMed, Scopus, and Embase until June 12, 2020. Our study focused on determining the prevalence of antibiotic resistance in MTB isolates, with subgroup analyses based on year, location, and drug susceptibility testing (DST) methods.

Efficient removal of microcystin-LR from contaminated water using water-stable MIL-100(Fe) synthesized under HF-free conditions.

Cyanobacterial algal hepatotoxins, called microcystins (MCs), are a global health concern, necessitating research on effective removal methods from contaminated water bodies. In this study, we synthesized non-fluorine MIL-100(Fe) using an environmentally friendly room-temperature method and utilized it as an adsorbent to effectively remove microcystin-LR (MC-LR), which is the most toxic MC congener. MIL-100(Fe) was thoroughly characterized, and its adsorption process was investigated under various conditions.

Advancements in combined electrocoagulation processes for sustainable wastewater treatment: A comprehensive review of mechanisms, performance, and emerging applications.

This review explores the potential and challenges of combining electrochemical, especially electrocoagulation (EC) process, with various - wastewater treatment methods such as membranes, chemical treatments, biological methods, and oxidation processes to enhance pollutant removal and reduce costs. It emphasizes the advantages of using electrochemical processes as a pretreatment step, including increased volume and improved quality of permeate water, mitigation of membrane fouling, and lower environmental impact. Pilot-scale studies are discussed to validate the effectiveness of combined EC processes, particularly for industrial wastewater.

Unlocking the potential of Tunisian dam sediment: optimizing zeolite X synthesis via Taguchi and Box-Behnken methods for sustainable resource recovery and versatile applications.

The Tunisian Lebna dam sediment was utilized to create the zeolite faujasite type Na-X. The aim of this investigation is to optimize the yield of Na-X zeolite using alkaline fusion hydrothermal treatment. Taguchi orthogonal array design was employed with nine trials to explore operating parameters including fusion temperature and time, activator type, and sediment type.

Trends in the Antibiotic Resistance of Non-Tuberculous Mycobacteria in Iran: A Systematic Review and Meta-Analysis.

Background: Non-tuberculous mycobacteria (NTM) infections have been continuously increasing as major concerns of public health in Iran. Because innate resistance of NTM species, the treatment of these infections is difficult task, but until now resistance pattern of NTM and suitable regimens are not determined.

Methods: We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until Dec 2022).

Detection of qacΔE Efflux Pump Gene among the Clinical Isolates of Escherichia coli and its Correlation with Resistance to Disinfectants.

Background: Disinfectants and antiseptics inhibit the dissemination of pathogenic organisms in hospitals but often cause disinfectant-resistant microorganisms, an important factor for nosocomial infection. This study aimed to evaluate the correlation between qacΔE efflux pump gene and its resistance to disinfectants among Escherichia coli clinical isolates.

Methods: A total of 97 E.

Facile and innovative application of surfactant-modified-zeolite from Austrian fly ash for glyphosate removal from water solution.

This study highlights a pioneering approach in the development of an efficient, affordable, and economically feasible adsorbent specifically tailored for the removal of glyphosate (Gly) from contaminated water. To accomplish this objective, a low-cost and pure NaA Zeolite (NaAZ) was synthesized with 93% crystallinity from Austrian fly ash (AFA) as a precursor for the first-time. Taguchi design was employed to optimize critical parameters such as the SiO/AlO ratio, alkalinity concentration, time, and temperature.

Aptamer-modified metal organic frameworks for measurement of food contaminants: a review.

The measurement of food contaminants faces a great challenge owing to the increasing demand for safe food, increasing consumption of fast food, and rapidly changing patterns of human consumption. As different types of contaminants in food products can pose different levels of threat to human health, it is desirable to develop specific and rapid methods for their identification and quantification. During the past few years, metal-organic framework (MOF)-based materials have been extensively explored in the development of food safety sensors.

The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis.

Background: Helicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally.

Study on phosphate removal from aqueous solutions using magnesium-ammonium- and zirconium-modified zeolites: equilibrium, kinetic, and fixed-bed column study.

Eutrophication is an environmental issue which occurs when the environment becomes enriched with nutrients. Phosphorus (P) is a key nutrient limiting the phytoplankton and algal growth in many aquatic environments. Therefore, P removal could be a promising technique to control the eutrophication.

Global status of phenotypic pyrazinamide resistance in clinical isolates: an updated systematic review and meta-analysis.

Pyrazinamide (PZA) is an essential first-line tuberculosis drug for its unique mechanism of action active against multidrug-resistant-TB (MDR-TB). Thus, the aim of updated meta-analysis was to estimate the PZA weighted pooled resistance (WPR) rate in M. tuberculosis isolates based on publication date and WHO regions.

Nosocomial infections and antimicrobial susceptibility patterns among patients admitted to intensive care unit of Imam Khomeini hospital in Ilam, Iran.

Introduction: Nosocomial infections (NIs) are a major challenge worldwide. Identification of antibiotic resistance pattern extended spectrum beta-lactamases (ESBLs) and carbapenem-resistant Enterobacteriaceae (CRE) were the objectives of this study.

Methods: In this cross-sectional study, the antimicrobial susceptibility pattern of bacterial isolates collected from patients with NIs in ICU was determined.

Bacterial community of chronic rhinosinusitis patients and therapeutic ultrasound efficacy: clinical trial study.

Background And Objectives: Bacterial involvement in chronic rhinosinusitis (CRS) condition made it difficult to treat using available antibiotic therapy. Therapeutic ultrasound was investigated here to evaluate bacterial diversity and quantity before and after continuous/pulsed ultrasound strategy compared to control patients.

Materials And Methods: Totally, 34 CRS patients were studied in three groups, including continuous ultrasound, pulsed ultrasound and control.

Green and facile synthesis of lignin/HKUST-1 as a novel hybrid biopolymer metal-organic-framework for a pH-controlled drug release system.

This manuscript describes the synthesis and characterization of a hybrid polymer/HKUST-1 composite for oral drug delivery. A green, one-pot approach was employed to synthesize the modified metal-organic frameworks (MOFs) composite using alkali lignin as a novel pH-responsive biopolymer carrier for the simulated oral delivery system. Several analytical techniques, including Fourier transform infrared (FTIR), X-ray powder diffraction (XRPD), Brunauer-Emmett-Teller (BET), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) were used to analyze the chemical and crystalline structure of HKUST-1 and L/HKUST-1 composite.

Characterization of the short-term temporal variability of road dust chemical mixtures and meteorological profiles in a near-road urban site in British Columbia.

: Non-tailpipe emissions driven by springtime road dust in northern latitude communities is increasing in importance for air pollution control and improving our understanding of the health effects of chemical mixtures from particulate matter exposure. High-volume samples from a near-road site indicated that days affected by springtime road dust are substantively different from other days with respect to particulate matter mixture composition and meteorological drivers. The high load of trace elements in PM on high road dust days has important implications for the acute toxicity of inhaled air and subsequent health effects.

Molecular characterizations of antibiotic resistance, biofilm formation, and virulence determinants of Pseudomonas aeruginosa isolated from burn wound infection.

Background: Burn injuries result in disruption of the skin barrier against opportunistic infections. Pseudomonas aeruginosa is one of the main infectious agents colonizing burn wounds and making severe infections. Biofilm production and other virulence factors along with antibiotic resistance limit appropriate treatment options and time.

Molecular Characterization of Resistance to Second-Line Anti-Mycobacterial Drugs among Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis.

Background: The emergence of multidrug resistance and extensively drug-resistant tuberculosis is a serious public health crisis. Using rapid and inexpensive molecular methods such as HRM assay in the detection of second-line drugs resistance in M. tuberculosis would be helpful in the treatment and control of XDR tuberculosis cases.

Brain Abscess Caused by in a Diabetic Patient: A Rare Case Report.

Nocardial brain abscess is usually associated with immunodeficiency, but can sometimes emerge in healthy individuals. This infection can be acquired through inhalation or direct inoculation of the bacteria, followed by dissemination to various organs, including the brain, through blood circulation. Mortality rate due to nocardial cerebral abscess is three times higher than that associated with cerebral abscess caused by other types of bacteria.