Expression of retinoid receptors in sebaceous cell carcinoma.

Purpose: The aim of this study is to investigate whether there are any abnormalities in the in vivo expression of retinoid acid receptors (RAR-alpha, RAR-beta and RAR-gamma) and retinoid X receptors (RXR-alpha, RXR-beta and RXR-gamma) in sebaceous cell carcinoma.

Methods: Expression of retinoid receptors in paired specimens of cancerous tissues (n = 10) and adjacent normal tissues (n = 10) from 10 patients with sebaceous cell carcinoma was studied immunohistochemically by using anti-retinoid receptor antibodies.

Results: In eight of the 10 normal tissue samples, all six receptors were expressed.

Retinoid receptor subtypes in sebaceous cell carcinoma of the eyelid.

Purpose: To study retinoid receptor expression in sebaceous cell carcinoma of the eyelid.

Methods: Expression of retinoid receptors (RAR alpha, beta, and gamma and RXR alpha, beta, and gamma) in tumor specimens from 10 patients with sebaceous cell carcinoma of the eyelid and in 3 normal incidental tarsus specimens from healthy adults without cancer was studied immunohistochemically by using antiretinoid receptor antibodies.

Results: In all 3 specimens of normal tarsus, all 6 retinoid receptors were expressed.

Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications.

Objective: To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas.

Design: Retrospective observational case series.

Participants: Six patients with orbital lymphangioma treated at four institutions between March 2000 and December 2002.