Native human and mouse skin infection models to study Candida auris-host interactions.

The World Health Organization (WHO) declared certain fungal pathogens as global health threats for the next decade. Candida auris (C. auris) is a newly emerging skin-tropic multidrug-resistant fungal pathogen that can cause life-threatening infections of high mortality in hospitals and healthcare settings.

Neurotoxicity of silver nanoparticles in the animal brain: a systematic review and meta-analysis.

Objective: About 30% of all nanoparticle products contain silver nanoparticles (AgNPs). With the increasing use of AgNPs in industry and medicine, concerns about the adverse effects on the environment, and the possible toxicity of these particles to primary cells and towards organs such as the brain and nervous system increased. In this paper, the toxicity of AgNPs in neurons and brain of animal models was investigated by a systematic review and meta-analysis.

The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis.

Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS.After extensive searches, the full text of 30 related studies was reviewed and data mining completed.

The investigation into the effect of the length of RGD peptides and temperature on the interaction with the αIIbβ3 integrin: a molecular dynamic study.

The tripeptide Arg-Gly-Asp acid (RGD) is a protein sequence in the binding of proteins to cell surfaces, and is involved in various biological processes such as cell adhesion to the extracellular matrix, platelet activation, hemostasis, etc. The C2 domain of the Von Willebrand Factor (VWF), containing the RGD motif, plays an important role in the initial homeostasis process. It binds to the αIIbβ3 integrin and stimulates platelet aggregation.

Quantification of zinc intoxication of after phagocytosis by primary macrophages.

Zinc (Zn) is a trace element, playing pivotal roles during host-pathogen interactions. Macrophages can sequester Zn and restrict bioavailability or increase phagolysosomal Zn to kill pathogens. This method quantifies Zn-mediated clearance of the human fungal pathogen after phagocytosis by innate immune cells.

Morphophysiological changes of wild species under physical conditions during the cultivation process.

Depending on the physical environmental conditions, cultivation process can have significant effects on the wild plants' morphophysiological characteristics is an Iranian wild endemic medicinal plant species and its cultivation preformed under different Soil Textures (ST) and Soil Moisture Regimes (SMRs). Controlled pot culture conditions performed with light, moderate, heavy STs and a set of SMRs at 100% Field Capacity (FC), 70%FC and 30% FC. Plant cultivated in heavy STs had higher performance in all measured treats.

Effect of soil and physiographic factors on ecological plant groups in the eastern Elborz mountain rangeland of Iran.

To investigate the cause of differences among ecological plant groups in the east of the Elborz mountain rangeland, the role of edaphical and topographical characteristics was considered. Two ordination techniques, detrended correspondence analysis (DCA) and canonical correspondence analysis (CCA), were used. The values of slope, aspect, altitude and lithology information were provided by Geographic Information System (GIS), and geomorphological land units were determined by intersection of overlaid data layers.