Publications by authors named "Hossain Sarah"

Article Synopsis
  • The study presents a new phagemid-based system that produces CRISPR-Cas13a-loaded antibacterial capsids (AB-capsids) specifically targeting multidrug-resistant Staphylococcus aureus.
  • By optimizing phagemid copy numbers, researchers achieved higher yields and purity of AB-capsids, illustrating a direct relationship between phagemid quantity and capsid production.
  • The developed AB-capsids effectively eliminate targeted S. aureus strains while leaving non-target strains unharmed, showcasing their potential as effective tools against antibiotic-resistant bacteria.
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Article Synopsis
  • The lab created a phagemid system to generate CRISPR-Cas13a-antimicrobial capsids specifically targeting MRSA to combat rising antimicrobial resistance.
  • They faced a challenge with unwanted wild-type phage production during packaging, which was addressed by introducing silent mutations to reduce contamination while maintaining efficiency.
  • The optimized system showed effective sequence-specific killing of MRSA strains but highlights the need for further research on its effectiveness against other bacteria and in real body conditions.
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  • The study focuses on oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA), which poses new treatment challenges due to its ability to develop resistance through chromosomal mutations.
  • Researchers analyzed six mutant strains with decreased oxacillin susceptibility, examining how mutations in RNA polymerase (RNAP) genes led to transcription dysfunction and an accumulation of certain metabolites.
  • The findings indicated that these mutations resulted in cell wall thickening, which ultimately decreased the mutants' susceptibility to β-lactam antibiotics, highlighting the need for a better understanding of these mechanisms for effective clinical management.
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Drug-induced urine discoloration, although usually benign, can still raise concern in healthcare facilities. This case report presents the second case of purple urine discoloration associated with cefiderocol in a 64-year-old male admitted to the intensive care unit for ventilator-associated pneumonia. The patient required broad-spectrum antibiotic treatment with vancomycin, cefiderocol, amikacin, and micafungin.

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Pancreatic tuberculosis (TB) warrants heightened suspicion in individuals with pancreatic lesions and risk factors such as HIV, organ transplantation, or pertinent immigration history. We present a 38-year-old man who presented with hemodynamically unstable gastrointestinal bleeding. He was found to have pancreatic TB complicated by a duodenal ulcer with fistula.

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Family planning programs in Bangladesh have been successfully operating for over half a century, achieving phenomenal reductions in fertility rates. Acknowledging restrictions on women's freedoms, much of the initial program design was concentrated on giving household supplies for women priority. However, one unfortunate impact of these outreach services is that, by bypassing the opportunity to challenge patriarchal attitudes directly, they inadvertently reinforce the power relationships of the status quo.

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Article Synopsis
  • Non-menstrual toxic shock syndrome (non-mTSS) is a severe illness linked to superantigen-producing strains such as those that produce TSST-1, but the rarity of TSS cases remains largely unexplained.
  • Researchers measured TSST-1 production in 541 clinical isolates, comparing strains from non-mTSS patients with those from other conditions, and investigated the role of specific mutations in the promoter affecting TSST-1 inducibility by human serum.
  • Results indicated that a small percentage of clinical isolates produced more TSST-1 in the presence of serum, particularly in non-mTSS strains from clonal complex (CC)-5, with certain genetic variations in the promoter implicated in this serum-induced induction.
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A 71-year-old Pakistani man with poorly controlled type 2 diabetes mellitus presenting with worsening mental status, abdominal pain, and oral intake for the past seven days was found to have pyogenic hepatic abscess with unculturable bacteria and subsequently found to have rare bacteremia.

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Caffeine is one of the most frequently used stimulants worldwide. It is, therefore, subject to frequent intentional and unintentional misuse. However, severe erosive esophagitis due to acute caffeine overdose is extremely rare.

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A 32-year-old homosexual male presented with suprapubic pain. Computed tomography showed rectal wall thickening. Flexible sigmoidoscopy showed small pockets of pus that were opened with mucosal biopsies, and additional pus was diffusely expressed from the rectal wall by applying blunt pressure with the biopsy forceps.

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  • Despite reducing roadside nitrogen oxides (NOx) in Hong Kong, nitrogen dioxide (NO2) levels remain unchanged, possibly due to an increasing percentage of primary NO2 emissions.
  • The population is at risk from these traffic-related pollutants, especially in congested areas surrounded by tall buildings.
  • An analysis showed that the primary NO2 fraction from vehicle emissions rose from 2% in 1998 to 13% in 2008, highlighting the need for future vehicle emission controls to address primary NO2 specifically, alongside overall NOx reduction.
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Objectives: To examine the relationship between meteorological factors and epidemiological pattern of Japanese encephalitis in Linyi City during 1956-2004.

Methods: Autoregressive integrated moving average (ARIMA) models were used to evaluate the relationship between monthly JE incidence and weather factors. Logarithmic transformation was applied to the JE incidence series to assure the normality and homogeneity of variance of the residuals.

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Primary neuroendocrine tumors of the gallbladder (GB) and extrahepatic biliary ducts (EHBDs) include carcinoid tumors and small-cell carcinomas (SCCs). They are uncommon, and therefore, little is known about their demographics and clinical course. From National Cancer Institute's Surveillance, Epidemiology, and End Results program (1973-2005), we analyzed the demographics and 10-year relative survival rates of carcinoids and SCCs of the GB and EHBD according to histologic type and stage.

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