Publications by authors named "Hoshina D"
Article Synopsis
- - Bosutinib, a common treatment for chronic myeloid leukemia, often leads to skin reactions known as cutaneous drug eruptions, particularly Fixed Drug Eruption (FDE).
- - Non-Pigmenting Fixed Drug Eruption (NPFDE) can be difficult to diagnose and may be linked to dosage levels of medications like levetiracetam.
- - The report discusses a case of dose-dependent NPFDE caused by bosutinib, suggesting that adjusting the dosage of essential medications may be a useful strategy in managing these skin reactions.
We report a case of pyoderma gangrenosum (PG) caused by secukinumab, which was successfully treated with risankizumab. We also reviewed reported cases of PG caused by interleukin (IL)-17 inhibitors. The clinical course of this case indicates that IL-23 may play an important role in the pathogenesis of PG and therefore IL-23-targeting therapies may be a treatment option for PG.
View Article and Find Full Text PDFAngiosarcoma is a rare malignant tumor derived from endothelial cells, and its prognosis is poor because advanced angiosarcoma is often resistant to taxane therapy. Endoglin (CD105) acts as a coreceptor for TGF-β signaling and is overexpressed in tumor-associated endothelial cells and enhances tumor angiogenesis. Numerous clinical trials are testing the effectiveness of anti-endoglin antibodies in various types of malignancies.
View Article and Find Full Text PDFRefractory juvenile psoriatic uveitis without arthritis: a literature review.
J Eur Acad Dermatol Venereol
April 2020
Background: Previous studies have indicated that MFG-E8 enhances tumor cell survival, invasion and angiogenesis. However, the role of MFG-E8 in angiosarcoma (AS) has not been clarified.
Objective: Objective was to elucidate the mechanism of the regulation by MFG-E8 in AS and the association between MFG-E8 and clinicopathological features of AS.
Background: Angiosarcoma is a rare malignant tumor with a poor prognosis. It is known that hypoxic condition activates tumor progression in several cancers. Additionally, hypoxic tumor microenvironment accelerates immune escape.
View Article and Find Full Text PDFCutaneous angiosarcoma (CAS) is a malignant sarcoma with poor prognosis. Programmed cell death-1 (PD-1)/programmed cell death-1 ligand-1 (PD-L1) expression reflects antitumor immunity, and is associated with patient prognosis in various cancers. The purpose of this study is to investigate the relationship between PD-1/PD-L1 expression and CAS prognosis.
View Article and Find Full Text PDFBackground: Angiosarcoma is a rare malignant neoplasm derived from endothelial cells, and because advanced angiosarcoma is resistant to standard chemotherapy its prognosis is poor. Therefore, new therapies are urgently needed. Heat shock protein (HSP)90 has been identified as a molecular chaperone that regulates various cancer-related proteins.
View Article and Find Full Text PDFBackground: The prognosis of angiosarcoma is poor and a novel treatment option for the disease is desired. The aim of this study was to investigate the prognostic significance of Forkhead box M1 (FOXM1), a transcription factor that regulates cell-cycle progression and various crucial processes in tumor progression, and its potential as a new therapeutic target.
Methods: We investigated 125 angiosarcoma clinical samples (94 primary lesions and 31 metastatic lesions in 94 patients) and a human angiosarcoma cell line (HAMON) using immunohistochemical staining and molecular biological approaches.
Successful treatment of subcorneal pustular dermatosis with maxacalcitol.
Clin Exp Dermatol
January 2016
Background: Food-dependent exercise-induced anaphylaxis (FDEIA) is a serious food allergy in which anaphylaxis develops when exercise is performed within several hours after food intake. The precise mechanism underlying allergic sensitization in FDEIA has been an important issue but remains poorly understood.
Objectives: We aimed to elucidate the pathomechanism including the route of allergen sensitization involved in FDEIA.