Publications by authors named "Hoseong Yang"
Article Synopsis
- - Scleroderma is an autoimmune disorder that causes severe fibrosis in the skin and internal organs, leading to the activation of fibroblasts that transform into myofibroblasts (MFBs) capable of producing excess collagen.
- - TLY012, a specialized engineered protein, promotes the death of these activated MFBs by targeting their specific death receptors, effectively blocking their harmful effects.
- - In animal studies, TLY012 has been shown to reverse skin fibrosis nearly to its normal state, highlighting the TRAIL pathway as a promising therapeutic target for treating scleroderma fibrosis.
Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key angiogenic stimulators during normal development and wound healing, as well as in a variety of pathological conditions. Recent studies have demonstrated a synergistic effect of VEGF and PlGF in pathological angiogenesis and suggest a role for PlGF in amplifying VEGF action in endothelial cells. We show here in the mouse model of oxygen-induced retinopathy that VEGF is significantly increased (P<0.
View Article and Find Full Text PDFPurpose: Pigment epithelium-derived factor (PEDF) has been demonstrated to suppress ocular angiogenesis in several animal models. In this study, we sought to measure the levels of PEDF and vascular endothelial growth factor (VEGF) in the vitreous of patients with and without ocular neovascular disorders.
Design: Case-control study of patients undergoing intraocular surgery for a variety of neovascular and nonneovascular conditions.
Vascular endothelial growth factor (VEGF) is a critical stimulus for both retinal and choroidal neovascularization, and for diabetic macular edema. We used mouse models for these diseases to explore the potential of gene transfer of soluble VEGF receptor-1 (sFlt-1) as a treatment. Intravitreous or periocular injection of an adenoviral vector encoding sFlt-1 (AdsFlt-1.
View Article and Find Full Text PDFPurpose: To determine the effect of pigment epithelium-derived factor (PEDF) in a mouse model of ischemia-induced retinal neovascularization and on vascular endothelial growth factor (VEGF)--induced migration and growth of cultured microvascular endothelial cells.
Methods: Human recombinant PEDF was expressed in the human embryonic kidney 293 cell line and purified by ammonium sulfate precipitation and cation exchange chromatography. C57BL/6 mice were exposed to 75% oxygen from postnatal day (P)7 to P12 and then returned to room air.