Rediscovering the chemistry of the species: potential fungi for metabolites and enzymes of biological, industrial, and environmental values.

Endophytic fungi have a strong affinity for producing the same or comparable compounds to those produced by their hosts. Herein, genetic diversity and environmental adaptation of the species were briefly investigated. The genetic flexibility in represents an evolutionary mechanism that allows them to respond effectively to environmental changes.

Studying the effects of secondary metabolites isolated from R.Br. leaves on MDA-MB-231 breast cancer cells.

The various therapeutic drugs that are currently utilized for the management of cancer, especially breast cancer, are greatly challenged by the augmented resistance that is either acquired or de novo by the cancer cells owing to the long treatment periods. So, this study aimed at elucidating the possible anticancer potential of four compounds 7, 4', 7'', 4'''-tetra--methyl amentoflavone, hesperidin, ferulic acid, and chlorogenic acid that are isolated from leaves -butanol fraction for the first time. The MTT assay evaluated the cytotoxic action of four isolated compounds against MDA-MB-231 breast cancer cells and oral epithelial cells.

Evaluation of A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies.

Toxoplasmosis and cancer are life-threatening diseases with worldwide distribution. However, currently used chemosynthetic treatments are not devoid of their own intrinsic problems. Natural metabolites are gaining attention due to their lower side effects.

Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di--glucoside from Miq. Cultivated in Egypt.

Toxoplasmosis and cancer are serious worldwide diseases, and the available drugs cause serious side effects. Investigation for new alternative therapies from natural sources is now an increasing concern. Herein, we carried out, for the first time, an in vitro screening of Miq.