Publications by authors named "Hortense Wilmot-Roussel"
Context: The cortisol secretion of adrenocortical adenomas can be either subtle or overt. The mechanisms leading to the autonomous hypersecretion of cortisol are unknown.
Objective: The objective of the study was to identify the gene expression profile associated with the autonomous and excessive cortisol secretion of adrenocortical adenomas.
Identification of a CpG island methylator phenotype in adrenocortical carcinomas.
J Clin Endocrinol Metab
January 2013
Purpose: DNA methylation is a mechanism for gene expression silencing in cancer. Limited information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 locus is common in adrenocortical carcinomas.
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- Researchers are studying adrenocortical tumors (ACT) to find out how to tell if they are cancerous and how to predict their behavior.
- They found that cancerous tumors have more genetic changes compared to non-cancerous tumors.
- A new tool was created using these genetic changes to help doctors identify cancerous tumors accurately, which could help in deciding the best treatment.