Risk and clinical impact of bacterial resistance/susceptibility to silver-based wound dressings: a systematic review.

Objective: To perform a systematic review of the literature on bacterial resistance, tolerance and susceptibility of silver within the context of wound therapy using silver-based dressings.

Methods: A literature search was carried out using PubMed, Embase and Cochrane Library databases, the focus was whether results from microbiological experimental tests with reference strains and clinical wound isolates are reflected in clinical practice with regards to their 'resistance' profiles, comparable with those observed for antibiotics. The search results were allocated to six categories: resistance and resistance mechanism, tests with standard strains and wound isolates, prevalence and incidence, impact on clinical practice and impact on antibiotic therapy as well as reviews, expert opinions and consensus.

Evidence for silver in wound care - meta-analysis of clinical studies from 2000-2015.

Background: Given that the scientific evidence for silver in wound care is generally considered insufficient, there is uncertainty among users regarding its clinical use.

Material And Methods: A group of experts evaluated the clinical studies on silver in wound management published from 2000-2015.

Results: Overall, 851 articles were identified, 173 of which were included and categorized.

Evidenz von Silber in der Wundbehandlung - Metaanalyse der klinischen Studien von 2000-2015.

Hintergrund: Da die wissenschaftliche Evidenz für Silber in der Wundbehandlung meist als unzureichend angesehen wird, besteht für die Anwender eine Unsicherheit hinsichtlich des klinischen Einsatzes.

Material Und Methodik: Von einer Expertengruppe wurden die publizierten klinischen Studien zu Silber in der Wundbehandlung für den Zeitraum 2000-2015 ausgewertet.

Ergebnisse: Es konnten 851 Artikel identifiziert werden, von denen 173 Artikel eingeschlossen und kategorisiert wurden.

Octenidine in combination with polymethylmethacrylate: a new option for preventing infection?

Background: Orthopedic implant infections represent a serious complication for both patient and surgeon. In order to minimize this risk, it has become standard practice in surgery and orthopedics to add antimicrobial substances to the polymethylmethacrylate (PMMA) bone cement. The aim of this study is to find new options for preventing infection by using alternative adjuvants in combination with PMMA.