Low mood and response to Levothyroxine treatment in Indian patients with subclinical hypothyroidism.

Background And Aim: There is considerable controversy regarding the association of subclinical hypothyrodism (SCH) and depression. We studied the association of SCH with low mood and also investigated the effects of L-thyroxine (LT4) therapy on improvement of symptoms.

Methods: Three hundred patients with SCH and 300 age and sex-matched healthy controls were studied.