Publications by authors named "Horev A"

This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls.

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Extensive research has been published on atopic dermatitis (AD), a prevalent skin condition among pediatricians. To assess the pediatric representation in the most cited literature on AD, using bibliometric analysis. Web of Science citation indexing database was used to identify publications with "atopic" and "dermatitis" or "eczema" in their title.

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Article Synopsis
  • Alopecia Areata (AA) is an autoimmune disease that influences white blood cell activity, but previous research hasn't linked blood ratios to the condition's severity.
  • A study comparing various blood cell ratios in over 147,000 AA patients and 141,000 healthy controls found higher Neutrophils-to-Lymphocytes Ratio (NLR) and Eosinophils-to-Lymphocytes Ratio (ELR) in AA patients, especially in those with moderate-severe cases.
  • The findings suggest that these blood ratios could be useful for predicting and managing AA, contrary to earlier studies, making them a cost-effective tool for disease assessment.
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Objective: Patients with chronic idiopathic intracranial hypertension (IIH) commonly experience a high level of disability and low satisfaction with medical treatment. We aim to evaluate long-term functional improvement and patient satisfaction in IIH patients with similar symptoms by comparing venous sinus stenting (VSS) to standard medical therapy.

Methods: We conducted a cross-sectional questionnaire study of 111 IIH patients, comparing 37 adult female patients who underwent venous sinus stenting with 74 patients treated medically.

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A substantial body of literature has been published on acne vulgaris (AV) in the past five decades. Bibliometric analysis (BA) is a scientific, statistical evaluation review of published articles, providing a quantitative assessment of past research. The Web of Science (webOS) citation indexing database was used on 11 June 2023 to identify the top 100 cited articles on AV.

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Background: Prior studies demonstrated conflicting results regarding hematologic ratios in acne patients. We sought to further characterize hematologic ratios in acne patients, according to demographics and acne severity.

Methods: National, retrospective cohort study of 122,822 patients using medical records from 2005 to 2024 of patients insured with the largest public healthcare organization in Israel, Clalit Health Maintenance Organization.

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  • Traumatic brain injury (TBI) is a leading cause of death and disability in young individuals, posing significant public health and economic issues, with current treatment options being inadequate.
  • This study utilizes a rat model to investigate the disruption of the blood-brain barrier (BBB) using two assessment markers, focusing on understanding the brain dysfunction that occurs after TBI.
  • The research introduced a new method for evaluating BBB permeability by comparing it to traditional neuroimaging and proved effective, revealing different patterns of BBB disruption over time, with accurate sensitivity results.
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Vitiligo is characterized by depigmented skin lesions involving melanocyte defects and immune dysregulation. Haematological markers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been explored in various skin disorders. Given vitiligo's proposed pathogenesis, we hypothesized differences in NLR and PLR in vitiligo patients compared to controls.

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Introduction: Vitiligo is a skin disease affecting melanocytes, characterised by the development of depigmented skin lesions.

Methods: We used bibliometric analysis (BA) to identify high-quality research articles on vitiligo using criteria such as total citations, annual citations (AC) and journal impact factors. We extracted the 100 most-cited articles on vitiligo using the Web of Science database and analysed the results using Microsoft Excel 2019.

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Molluscum contagiosum (MC) is a common skin infection affecting children globally, including in Israel, which has a diverse population comprising mainly Jews (73.2%) and Arabs (21.1%).

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Lumbar puncture opening pressure (LPOP) exceeding 250mmHO is key in diagnosing idiopathic intracranial hypertension (IIH), per revised Friedman's criteria. Some patients do not meet LPOP criteria (with or without papilledema), despite having IIH-related symptoms and neuroimaging findings. This study aimed to investigate the radiological findings and clinical symptoms in patients suspected of having IIH without meeting the LPOP criteria.

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The aim of this study was to evaluate the long-term outcomes of a cohort of ophthalmologically resolved female idiopathic intracranial hypertension (IIH) patients. Our cross-sectional study included adult females with at least 6 months of ophthalmologically resolved IIH. Patients with papilledema or who underwent IIH-targeted surgical intervention were excluded.

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Article Synopsis
  • Molluscum contagiosum is a common skin infection in children, and a study analyzed 615 cases to compare facial lesions to non-facial ones from 2013-2022.
  • Facial lesions were more common in younger kids and exhibited less inflammation and itchiness compared to non-facial lesions.
  • Despite potential psychosocial impacts, the study suggests that both types of lesions can be treated similarly, indicating that facial lesions are not inherently more serious.
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Background: An extensive body of literature has been published regarding alopecia areata (AA) in the past 50 years. The current paper used a bibliometric analysis (BA) to identify high-quality research articles using criteria such as annual citations (ACs) and journal impact factor.

Objectives: To identify and analyze the top 100 most cited articles in AA scientific literature over the past 50 years using BA methods.

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Background: In the last 15 years, an increase in U.S. female dermatologists from 41 to 52.

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Introduction: Atopic dermatitis (AD) is a common chronic skin disease with an inflammatory pathophysiology that includes the activation of the innate and adaptive immune systems. We aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), and eosinophil-to-neutrophil ratio (ENR) in AD patients, according to age and disease severity.

Methods: This is a retrospective, population-based cohort study conducted between the years 2005 and 2020, comparing hematological markers of AD patients and sex-age-ethnicity-matched controls.

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The association between molluscum contagiosum and concomitant atopic dermatitis and its impact on clinical features and treatment outcomes remains unclear. This retrospective study, conducted in the paediatric dermatology clinic of a tertiary medical centre, aimed to compare molluscum patients with and without atopic dermatitis. A total of 615 children with molluscum were included, 13.

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  • Chronic spontaneous urticaria (CSU) is a skin condition that can significantly impact a person's quality of life, and markers of inflammation like neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios could be helpful in evaluating it.
  • A study analyzed data from over 13,500 patients diagnosed with urticaria to explore these inflammatory markers in different patient groups, including acute versus chronic cases and varying severities.
  • The findings indicated that CSU patients had higher inflammatory marker levels compared to those with acute urticaria, and higher levels correlated with more severe cases, suggesting these markers could help predict the severity and chronicity of urticaria.
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While the typical patient with idiopathic intracranial hypertension (IIH) is an obese female of childbearing age, there are unique patient populations, such as non-obese females, that have not been well studied. Characterizing this subpopulation may increase awareness our of it, which may prevent underdiagnosis and improve our understanding of IIH's underlying pathophysiology. We retrospectively reviewed electronic medical records and compared the clinical and radiological characteristics of non-obese (BMI < 30) and obese (BMI > 30) female patients with IIH.

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Background: Psoriasis is a common skin disorder linked to systemic inflammation and immune dysregulation. It is believed to involve activated T cells and neutrophils. Recent research has highlighted the potential role of hematological ratios, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), eosinophil-to-neutrophil ratio (ENR), and eosinophil-to-monocyte ratio (EMR), as markers for inflammatory skin diseases, including psoriasis.

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  • The study focuses on refining the diagnosis of allergic contact dermatitis in children due to increasing allergens and limited data.
  • Researchers analyzed patch test records from 367 children aged 2 to 18 in Israel who were tested using the European baseline series between 2014 and 2022.
  • Findings revealed that Farnesol was the most reactive compound in children, highlighting the effectiveness of extended testing for better diagnosis and potential regulatory measures.
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  • Hematological markers like eosinophil-to-lymphocyte (ELR), eosinophil-to-neutrophil (ENR), and eosinophil-to-monocyte (EMR) ratios could help assess skin diseases, but their specific connection to vitiligo was uncertain.
  • This study analyzed these markers in nearly 10,000 vitiligo patients and found that children had higher ratios than adults, and those with severe vitiligo exhibited even higher levels compared to mild cases.
  • Elevated ENR and EMR ratios were associated with a significantly increased risk of developing severe vitiligo up to 18 months before diagnosis, suggesting these markers could aid in the prognosis of the condition.
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Background: Recent years have seen significant exploration into the potential link between allergic contact dermatitis and atopic dermatitis, yielding contradictory findings.

Methods: A retrospective cohort analysis of children aged 2 to 18 who underwent patch testing at the pediatric dermatology clinic at a tertiary medical center in Israel was conducted.

Results: Overall, 367 patients were included in the study, 31.

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