Publications by authors named "Horea G Rus"
Article Synopsis
- Systemic lupus erythematosus is an autoimmune disease causing damage to kidneys and organs, which was studied in the context of nephrotoxic nephritis (NTN) as a model for lupus nephritis.
- The research focused on response gene to complement-32 (RGC-32), finding that its absence in RGC-32 knockout (KO) NTN mice led to reduced proteinuria, improved kidney function, and less severe kidney damage.
- RGC-32 KO mice also showed decreased recruitment of certain immune cells and less renal fibrosis, suggesting that RGC-32 could be a promising target for new treatments aimed at combatting conditions like lupus nephritis.
Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-β that mediates its profibrotic activity. In this study, we report that RGC-32 is preferentially upregulated during Th17 cell differentiation.
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