Publications by authors named "Horchani Ali"
Background: (PSMA+,PSA+) and (PSMA+,PSA-) are the two most individual clones that we have previously identified during prostate cancer (PC) progression. However, molecular signatures associated with these distinct PSMA-PSA prostate clones and their specific correlation with disease outcome is yet to be defined.
Aim: Since Akt is a major pathway involved in the critical activating events that leads to malignant form of the disease, we studied the involvement of full Akt activation (T308+,S473+) connected with serum PSA levels, tissue PSMA expression and angiogenic activity on the emergence of (PSMA+,PSA+) and (PSMA+,PSA-) PC clones.
Article Synopsis
- * Data from 333 patients showed that taxane therapy significantly improved overall and progression-free survival compared to nontaxane therapy, even among frail patients, and was generally well tolerated with specific side effects.
- * The findings indicate that taxane therapy may be more beneficial for older adults with mCRPC than other treatments, and treatment decisions should not solely rely on a patient's age.
Background: Incidence of benign prostatic hyperplasia (BPH), one of the most common conditions affecting adult men, increases dramatically after the age of 50. The various symptoms of BPH, which include lower urinary tract symptoms (LUTS), can adversely affect quality of life (QoL) and sexuality and 1-Blockers are the most frequently prescribed oral medications as first-line treatment.
Aim: The objectives of this study try to evaluate QoL and sexuality in patients requiring treatment by Alfuzosin 10mg once daily according to physician decision in current practice and to identify patient's profile treated with Alfuzosin 10 mg under daily practice conditions by Tunisian urologists.
Background: Bladder papillomatosis is a diffuse tumor proliferation even up almost all of the bladder mucosa. We analyzed prognosis of this rare entity after conservative treatment.
Methods: We retrospectively analyzed epidemiological, clinical, therapeutic and evolutive data in 24 patients with newly diagnosed bladder transitional cell carcinoma papillomatosis.
Background: As promising targets for in vivo diagnostic,prognostic and therapeutic approaches, the distribution and staining pattern of prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA) in tumors are of significant interest.
Aims: To compare the cellular distribution and heterogeneity of PSA and PSMA expression in normal prostate (NP), benign prostatic hyperplasia (BPH) and primary prostatic tumors and to analyze their relation with the angiogenic activity according to Gleason grade (low, medium and high) in primary PC.
Methods: The study was carried out in 6 NP, 44 BPH and 39 PC.
Background: Post traumatic posterior urethral disruption is a common condition, its treatment is controversial.
Aim: To assess the long term results of endoscopic realignment compared with delayed urethroplasty, in the management of post traumatic urethral disruption.
Methods: Between February 2002 and March 2009, 30 patients have been operated for post traumatic posterior urethral disruption.
Background: Fournier's gangrene (FG) is a serious, extensive fulminant infection of the genitals and perineum. Indeed, despite antibiotics and aggressive debridement, the mortality rate of FG remains high.
Aim: Through our experience, we intent to identify effective factors in the survival of patients with FG and we try to determine how the Fournier's gangrene severity index score (FGSIS) is accurate.
Aim: To analyze the testicular cancer (TCa) incidence, diagnosis aspects, pathologic grade, stage, and survival in Tunisian men.
Methods: We studied all patients who had histopathologically confirmed TCa treated in La Rabta University-Hospital between 1991 and 2010. Baseline demographic data included age at diagnosis, year of diagnosis, clinical symptoms, stage at diagnosis, histologic type, management strategies and survival were analyzed.
Background: Bone metastasis is very frequent in prostate cancer. It is a turning point that marks the severity of the disease. Before metastasis become symptomatic, treatment preventing bone events should be indicated.
View Article and Find Full Text PDFBackground: The Bellini collecting duct carcinoma (CDC) is a very rare form of renal cell carcinoma (1%) associated with an extremely poor prognosis.
Aim: To study clinical and radiological characteristics of CDC.
Methods: From 1993 to 2002, 7 patients with CDC were treated at our institution.
Background: The transitional cell carcinoma within the bladder diverticular is a rare and poorly known entity.
Aim: To evaluate diagnostic and therapeutic approaches of transitional cell carcinoma within the bladder diverticular.
Methods: Thirty men and two women (median: 70 years; 44- 83 years) were included.
Background: Renal colics due to urinary stones are also common in women of childbearing age whether pregnant or not.
Aim: Through a review of literature, we evaluated diagnostic and therapeutic approaches in renal colic in pregnancy and lactation.
Methods: Review of literature.
Aim: To evaluate the efficacy and side-effects of Polidocanol used as sclerosing agent for testicular hydrocele.
Methods: One hundred and ninety men, with a median age of 55,9 years (40-89), treated for idiopatic hydrocele were assessed. After puncture and aspiration, the empty sac was instilled with 3% Polidocanol.
Background: Eosinophilic cystitis is a rare inflammatory pathology. It remains a poorly understood entity.
Aim: To report a series of adult cases of eosinophilic cystitis mimicking a bladder tumor.
Background: Cryptorchidism is a pathological condition defined as the failure of the testis descending into the scrotum. It is a rare condition in adults.
Aim: To study clinical and therapeutic aspects of cryptorchidism in adults.
Background: The present study was undertaken to relate the co-expression of prostate-associated antigens, PSMA and PSA, with the degree of vascularization in normal and pathologic (hyperplasia and cancer) prostate tissues to elucidate their possible role in tumor progression.
Methods: The study was carried out in 6 normal, 44 benign prostatic hyperplastic and 39 cancerous human prostates. Immunohistochemical analysis were performed using the monoclonal antibody CD34 to determine the angiogenic activity, and the monoclonal antibodies 3E6 and ER-PR8 to assess PSMA and PSA expression, respectively.