Publications by authors named "Horatiu Manea"
Article Synopsis
- The review discusses phytophotodermatitis, a skin reaction caused by certain plants when combined with UV light, detailing how specific compounds like furanocoumarins and psoralens lead to skin damage.
- It highlights recent advancements in understanding the skin's response mechanisms and identifies common phototoxic plant families and species, which help in recognizing risks associated with these plants.
- The review also covers diagnostic methods like patch testing and preventive measures such as wearing protective clothing, along with treatment options that have emerged from current research findings.
Solar ultraviolet radiation (UVR) is responsible for the development of many skin diseases, including malignant melanoma (MM). This study assessed the phototoxic effects of UVA, and UVB radiations on healthy and pathologic skin cells by evaluating the behavior of human keratinocytes (HaCaT) and MM cells (A375) at 24 h post-irradiation. The main results showed that UVA 10 J/cm exerted no cytotoxicity on HaCaT and A375 cells, while UVB 0.
View Article and Find Full Text PDFBetulinic acid (BA), a natural compound with various health benefits including selective antitumor activity, has a limited applicability in vivo due to its poor water solubility and bioavailability. Thus, this study focused on obtaining a BA nano-sized formulation with improved solubility and enhanced antitumor activity using silver nanocolloids (SilCo and PEG_SilCo) as drug carriers. The synthesis was performed using a chemical method and the physicochemical characterization was achieved applying UV-Vis absorption, transmission electron microscopy (TEM), Raman and photon correlation spectroscopy (PCS).
View Article and Find Full Text PDFIntroduction: Osteonecrosis of the jaw (ONJ) is a multifactorial condition associated with bisphosphonates (BPs) treatment, head and neck irradiation, malignancy, chemotherapy, periodontal disease or trauma. The first cases of BPs-related ONJ (BRONJ) were reported over a decade ago.
Patients, Materials And Methods: The study was retrospective and analyzed archived material.