Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas.

Three isolates collected from human mycetomas and showing an unusual brownish purple pigmentation on Bennett agar plates were analyzed by a polyphasic taxonomic approach, including morphological, biochemical, physiological, and chemotaxonomic properties coupled with genomic and phylogenetic analysis. It clearly appeared that these microorganisms were distinct from their closest phenotypic and genetic match, the most related species according to 16S rRNA gene sequence analysis being Nocardia pseudobrasiliensis. The data obtained indicated that the three clinical strains should be recognized as a new species for which the name Nocardia mexicana sp.

Comparison of different mathematical models for the tensile strength-relative density profiles of binary tablets.

During the last decade the evolution of the pharmaceutical dosage form design has been important. In controlled release matrix tablets, the tensile strength is an essential parameter to consider, because a minimal mechanical strength is needed for tablet production, handling and avoidance of any dose dumping during its use. Recent developments in percolation theory led to the theoretical proposal of lattice strength that was applied to the tensile strength of tablets.