Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) after arsenic exposure.

The present study investigated arsenic's effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or exposure age might play. Adult male and female mummichogs were exposed to 172 ppb, 575 ppb, or 1720 ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in 1720 ppb arsenic exposure group.

Physiological changes and differential gene expression in mummichogs (Fundulus heteroclitus) exposed to arsenic.

Arsenic has been detected as a contaminant in water bodies around the world. Although a number of studies have shown toxicity to adult fish, little is known about its effects on the offspring. However, human epidemiological studies have shown that arsenic increases the number of stillbirths and prematurely born infants.