Publications by authors named "Horacio Groshaus"
Lead poisoning may present with non-specific symptoms that may result in unnecessary investigations. We report a case of acute lead poisoning in a previously healthy 28-year-old man who presented with recurrent abdominal pain, jaundice, constipation, and weight loss. An extensive diagnostic work-up was completed with inconclusive results.
View Article and Find Full Text PDFBackground: The complex process of discharging patients from acute care to community care requires a multifaceted interaction between all health care providers and patients. Poor communication in a patient's discharge can result in post hospital adverse events, readmission, and mortality. Because of the gravity of these problems, discharge planning has been emphasized as a potential solution.
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- The study investigates the effects of inhaled salbutamol, a beta2 agonist, on acute lung injury (ALI) severity and duration in mechanically ventilated patients.
- The retrospective analysis included 86 patients divided into high-dose and low-dose groups, revealing that high-dose salbutamol (≥ 2.2 mg/day) significantly increased the days patients were alive and free from ALI complications.
- The findings suggest that higher doses of inhaled salbutamol could potentially minimize the duration and severity of ALI, indicating the need for further randomized controlled trials.
Background: Pneumonia is a common reason for hospital admission, and the cost of treatment is primarily determined by length of stay (LOS).
Objectives: To explore the changes to and determinants of hospital LOS for patients admitted for the treatment of community-acquired pneumonia over a decade of acute hospital downsizing.
Methods: Data were extracted from the database of Vancouver General Hospital, Vancouver, British Columbia, on patients admitted with community-acquired pneumonia (International Classification of Diseases, Ninth Revision, Clinical Modification codes 481.
Article Synopsis
- The study aimed to determine if variations in the IL-10 gene affect clinical outcomes in critically ill patients with sepsis, particularly comparing those with pneumonia to those with other sources of sepsis.
- A total of 550 patients were analyzed, identifying four main haplotypes of the IL-10 gene, with the CGG haplotype linked to higher 28-day mortality and more severe organ dysfunction in patients with pneumonia.
- The findings suggest that certain genetic variations in the IL-10 gene may help predict worse outcomes for patients suffering from pneumonia-related sepsis, but not for those with extrapulmonary sepsis.
Article Synopsis
- Acute lung injury (ALI) and acute respiratory distress syndrome involve complex inflammatory and coagulation processes, leading to lung damage and impaired fluid transport.
- Beta-2 agonists can enhance the clearance of fluid from the lungs, reduce inflammation, and promote bronchodilation, making them a potential treatment for ALI.
- The review emphasizes the need for more randomized controlled trials to fully understand the effectiveness of beta-2 agonists in treating pulmonary edema and ALI.