Publications by authors named "Hope B Chatwin"
Article Synopsis
- Efferocytosis, the process of phagocytosing apoptotic cells, is essential for maintaining tissue health and promotes anti-inflammatory responses in macrophages.
- When macrophages engulf these dying cells, they show increased levels of arginine-derived polyamines, specifically spermidine and spermine.
- This increase in polyamines is due to enhanced import mechanisms rather than the breakdown of the engulfed cells themselves, and blocking this import can hinder the anti-inflammatory effects of efferocytosis, suggesting that polyamines are crucial for immune system reprogramming.
