Urazolium diacetate as a new, efficient and reusable Brønsted acid ionic liquid for the synthesis of novel derivatives of thiazolidine-4-ones.

Urazolium diacetate catalyzed synthesis of new derivatives of 1,3-thiazolidine-4-ones (azo dispersive dyes family) multicomponent reaction of various aldehydes, thioglycolic acid and 4-aminoazobenzene under solvent-free reaction was reported. This avenue for the synthesis of new derivatives of thiazolidine-4-one has advantages as: short reaction times, high yields, green aspect of chemistry and environmental friendliness, easy workup, solvent-free conditions and convenient operation.

Preparation of a new Fe3O4/starch-g-polyester nanocomposite hydrogel and a study on swelling and drug delivery properties.

A new Fe3O4/starch-g-poly(ethylene phthalate) hydrogel nanocomposite was prepared using poly(ethylene phthalate) grafted onto starch as a biopolymer. The nanocomposite was characterized by FT-IR, XRD, DLS and SEM. FT-IR spectra proved that polyester had been grafted onto starch in a copolymerization reaction.

Synthesis of novel compounds containing morpholine and 5(4H)-oxazolone rings as potent tyrosinase inhibitors.

In this study, six new compounds containing morpholine and 5(4H)-oxazolone rings were synthesized. Structures of the new compounds using IR, (1)H NMR, mass spectroscopy and elemental analysis were characterized. All new compounds (4a-4f) have a strong inhibitory effect against mushroom tyrosinase.

Synthesis of novel compounds as new potent tyrosinase inhibitors.

In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a-5f) showed the most potent mushroom tyrosinase inhibition (IC₅₀ values in the range of 4.39 ± 0.

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.

Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde. The new compounds were fully characterized by spectroscopic techniques. All synthesized compounds exhibited high tyrosinase inhibitory behavior.

One-pot and efficient synthesis of triazolo[1,2-a]indazole-triones via reaction of arylaldehydes with urazole and dimedone catalyzed by silica nanoparticles prepared from rice husk.

A novel synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives by reaction of urazole, dimedone and aromatic aldehydes under conventional heating and microwave irradiation and solvent-free conditions using silica nanoparticles prepared from rice husk ash as catalyst is described. The new method features high yields, multicomponent reactions and environmental friendliness.

Dodecatungstophosphoric acid (H3PW 12O40), samarium and ruthenium (III) chloride catalyzed synthesis of unsaturated 2-phenyl-5(4H)-oxazolone derivatives under solvent-free conditions.

We found that dodecatungstophosphoric acid (H(3)PW(12)O40), samarium and ruthenium(III) chloride act as efficient catalysts for synthesis of unsaturated 2-phenyl-5(4H)oxazolone derivatives under solvent-free conditions. The key features of the reported protocols are short reaction times, high yields of products, ambient conditions and simple workup.

Synthesis of new 4(3H)-quinazolinone derivatives using 5(4H)-oxazolones.

New derivatives of 5(4H)-quinazolinone containing 2-imidazolin-5-one rings have been prepared from 5(4H)-oxazolone derivatives.