Setting up Multiplex Panels for Genetic Testing of Familial Hypertrophic Cardiomyopathy Based on Linkage Analysis.

Background: Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in genes encoding cardiac sarcomere proteins. Nowadays genetic testing of HCM plays an important role in clinical practice by contributing to the diagnosis, prognosis, and screening of high-risk individuals. The aim of this study was developing a reliable testing strategy for HCM based on linkage analysis and appropriate for Iranian population.

Cardiovascular risk factors in first-degree relatives of patients with premature coronary artery disease.

Objective: The objective of this study was to evaluate the prevalence of coronary risk factors among Iranian first-degree relatives of patients with premature coronary artery disease (PCAD) and compare them with the general population.

Methods And Results: The study comprised 144 siblings and offspring (aged 25-64 years) of patients with angiographically documented PCAD (< 55 years in men and < 65 years in women). Body mass index, blood pressure and smoking were investigated.