Review of the European Union Clinical Trials Regulation: Key Early Learnings from the United Kingdom Drug Information Association Medical Writing Committee.

The European Union Clinical Trials Regulation (EU CTR) provides new regulatory requirements for the preparation and submission of clinical trial documents. The United Kingdom Drug Information Association Medical Writing (UK DIA MW) Committee, with members from across the pharmaceutical industry, have reviewed the EU CTR and in this report, provide expert guidance on writing documents for submission in the EU CTR Clinical Trials Information System (CTIS) portal. Medical writers should be aware that the Investigator's Brochure containing the Reference Safety Information (RSI) must align with the annual safety report, and the RSI format must comply closely with the EU CTR.

Method for extracting the surface impedance of a generic reflective metasurface.

We develop a method for the extraction of the surface impedance tensor of a generic reflective metasurface using an analytic relation between the tensorial surface impedance and the four polarisation-dependent reflection coefficients. We apply this technique to experimental data obtained from a metasurface with a rhomboidal unit cell in the 16-26 GHz range, but note that it could be applied to reflective metasurfaces in any frequency regime. The extraction method can also be applied to model data to facilitate the design process of spatially graded tensorial metasurfaces that allow for full control of the form of the scattered field.

Multi-resonant tessellated anchor-based metasurfaces.

In this work, a multi-resonant metasurface that can be tailored to absorb microwaves at one or more frequencies is explored. Surface shapes based on an 'anchor' motif, incorporating hexagonal, square and triangular-shaped resonant elements, are shown to be readily tailorable to provide a targeted range of microwave responses. A metasurface consisting of an etched copper layer, spaced above a ground plane by a thin (< 1/10th of a wavelength) low-loss dielectric is experimentally characterised.

Multi-scale bullseye antennas.

We design, simulate and experimentally characterize a multi-scale bullseye antenna for the broadband manipulation of microwaves. The device achieves far-field beam-forming via tailored diffraction at the interface between two concentric bullseye geometries, with near-field energy concentration resulting from the overlap of the diffracted beams. This article is part of the theme issue 'Wave generation and transmission in multi-scale complex media and structured metamaterials (part 1)'.

Metamaterial Analogues of Strongly Coupled Molecular Ensembles.

The formation of polariton modes due to the strong coupling of light and matter has led to exciting developments in physics, chemistry, and materials science. The potential to modify the properties of molecular materials by strongly coupling molecules to a confined light field is so far-reaching and so attractive that a new field known as "polaritonic chemistry" is now emerging. However, the molecular scale of the materials involved makes probing strong coupling at the individual resonator level extremely challenging.

Absorption modes of Möbius strip resonators.

In this work, the electromagnetic response of a mathematically interesting shape-a Möbius strip-is presented, along with a ring resonator for comparison. Both resonators consist of a central lossy dielectric layer bounded by perfectly conducting layers. For the case of the Möbius strips, the computational results show that there are a family of half-integer wavelength modes within the dielectric layer.

The use of an Ebola virus reporter cell line in a semi-automated microtitration assay.

A variety of methods have been developed for quantification of infectious Ebola virus in clinical or laboratory samples, but existing methods often require extensive operator involvement, manual assay scoring, or the use of custom reagents. In this study, we utilize a recently developed Ebola-specific reporter cell line that expresses ZsGreen in response to Ebola virus infection, in conjunction with semi-automated processing and quantification techniques, to develop an unbiased, high-throughput microtitration assay for quantification of infectious Ebola virus in vitro. This assay was found to have equivalent sensitivity to a standardized plaque assay for quantifying viral titers.

The influence of temperature, humidity, and simulated sunlight on the infectivity of SARS-CoV-2 in aerosols.

Recent evidence suggests that respiratory aerosols may play a role in the spread of SARS-CoV-2 during the ongoing COVID-19 pandemic. Our laboratory has previously demonstrated that simulated sunlight inactivated SARS-CoV-2 in aerosols and on surfaces. In the present study, we extend these findings to include the persistence of SARS-CoV-2 in aerosols across a range of temperature, humidity, and simulated sunlight levels using an environmentally controlled rotating drum aerosol chamber.

Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces.

Coronavirus disease 2019 (COVID-19) was first identified in China in late 2019 and is caused by newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Previous studies had reported the stability of SARS-CoV-2 in cell culture media and deposited onto surfaces under a limited set of environmental conditions. Here, we broadly investigated the effects of relative humidity, temperature, and droplet size on the stability of SARS-CoV-2 in a simulated clinically relevant matrix dried on nonporous surfaces.

Epidemiology of injury and illness in 153 Australian international-level rowers over eight international seasons.

Aim: To report the epidemiology of injury and illness in elite rowers over eight seasons (two Olympiads).

Methods: All athletes selected to the Australian Rowing Team between 2009 and 2016 were monitored prospectively under surveillance for injury and illness. The incidence and burden of injury and illness were calculated per 1000 athlete days (ADs).

Airborne SARS-CoV-2 Is Rapidly Inactivated by Simulated Sunlight.

Aerosols represent a potential transmission route of COVID-19. This study examined effect of simulated sunlight, relative humidity, and suspension matrix on stability of SARS-CoV-2 in aerosols. Simulated sunlight and matrix significantly affected decay rate of the virus.

Simulated Sunlight Rapidly Inactivates SARS-CoV-2 on Surfaces.

Previous studies have demonstrated that SARS-CoV-2 is stable on surfaces for extended periods under indoor conditions. In the present study, simulated sunlight rapidly inactivated SARS-CoV-2 suspended in either simulated saliva or culture media and dried on stainless steel coupons. Ninety percent of infectious virus was inactivated every 6.

High efficiency photomodulators for millimeter wave and THz radiation.

Photomodulators for mm-wave and THz radiation are an essential component for many imaging and signal processing applications. While a myriad of schemes have been devised to enhance photomodulation by enhancing the light-matter interaction, there has been less focus on the photoconductive materials themselves, which are often the limiting factor. Here, we present an approach to increase the photomodulation efficiency of silicon by orders of magnitude, using post treatment of off-the-shelf silicon wafers.

Metamaterial Analogues of Molecular Aggregates.

Molecular aggregates are a fascinating and important class of materials, particularly in the context of optical (pigmented) materials. In nature, molecular aggregates are employed in photosynthetic light harvesting structures, while synthetic aggregates are employed in new generation molecular sensors and magnets. The roles of disorder and symmetry are vital in determining the photophysical properties of molecular aggregates, but have been hard to investigate experimentally, owing to a lack of sufficient structural control at the molecular level and the challenge of probing their optical response with molecular spatial resolution.

Broadband, slow sound on a glide-symmetric meander-channel surface.

The acoustic surface waves supported by hard surfaces patterned with repeat-period, meandering grooves are explored. The single, continuous groove forms a glide-symmetric surface, inhibiting the formation of a bandgap at the first Brillouin-zone boundary. Consequently, the acoustic surface waves exhibit an almost constant, sub-speed-of-sound, group velocity over a broad frequency band.

Isotropic Backward Waves Supported by a Spiral Array Metasurface.

A planar metallic metasurface formed of spiral elements is shown to support an isotropic backward wave over a narrow band of microwave frequencies. The magnetic field of this left-handed mode is mapped experimentally using a near-field scanning technique, allowing the anti-parallel group and phase velocities to be directly visualised. The corresponding dispersion relation and isofrequency contours are obtained through Fourier transformation of the field images.

Absence of Anderson localization in certain random lattices.

We report on the transition between an Anderson localized regime and a conductive regime in a one-dimensional microwave scattering system with correlated disorder. We show experimentally that when long-range correlations are introduced, in the form of a power-law spectral density with power larger than 2, the localization length becomes much bigger than the sample size and the transmission peaks typical of an Anderson localized system merge into a pass band. As other forms of long-range correlations are known to have the opposite effect, i.

Direct observation of negative-index microwave surface waves.

Waves propagating in a negative-index material have wave-front propagation (wavevector, k) opposite in direction to that of energy flow (Poynting vector, S). Here we present an experimental realisation at microwave frequencies of an analogous surface wave phenomenon whereby a metasurface supports a surface mode that has two possible wavevector eigenstates within a narrow band of frequencies: one that supports surface waves with positive mode index, and another that supports surface waves with negative mode index. Phase sensitive measurements of the near-field of surface waves across the metasurface show the contrasting spatial evolution of the two eigenstates, providing a unique opportunity to directly observe the negative-index phenomenon.

Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection.

There are currently no FDA-approved therapeutics available to treat Rift Valley fever virus (RVFV) infection. In an effort to repurpose drugs for RVFV treatment, a library of FDA-approved drugs was screened to determine their ability to inhibit RVFV. Several drugs from varying compound classes, including inhibitors of growth factor receptors, microtubule assembly/disassembly, and DNA synthesis, were found to reduce RVFV replication.

Normative MRI, ultrasound and muscle functional MRI findings in the forearms of asymptomatic elite rowers.

Objectives: Forearm injuries are common and debilitating to elite rowers. Chronic exertional compartment syndrome, intersection syndrome and proximal radial bone stress injuries have been documented in this population. This paper explores the imaging findings related to these conditions in asymptomatic elite rowers.

Massively sub-wavelength guiding of electromagnetic waves.

Recently a new form of ultra-thin flexible waveguide consisting of a conducting comb-like structure with a thickness of the order of 1/600(th) of the operating wavelength was presented. However, whilst the thickness of the guide was massively sub-wavelength, the remaining dimensions (the height and period of the comb) were much longer. In this paper we propose, and experimentally verify, that a modified guiding geometry consisting of a chain of ultra-thin conducting spirals allows guiding of electromagnetic waves with wavelengths that are many times (40+) longer than any characteristic dimension of the guide, enabling super-sub-wavelength guiding and localisation of electromagnetic energy.

Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication.

Venezuelan equine encephalitis virus (VEEV) is classified as a Category B Select Agent and potential bioterror weapon for its severe disease course in humans and equines and its potential for aerosol transmission. There are no current FDA licensed vaccines or specific therapies against VEEV, making identification of potential therapeutic targets a priority. With this aim, our research focuses on the interactions of VEEV with host microRNA (miRNA) machinery.

Removing singular refractive indices with sculpted surfaces.

The advent of Transformation Optics established the link between geometry and material properties, and has resulted in a degree of control over electromagnetic fields that was previously impossible. For waves confined to a surface it is known that there is a simpler, but related, geometrical equivalence between the surface shape and the refractive index, and here we demonstrate that conventional devices possessing a singularity - that is, the requirement of an infinite refractive index - can be realised for waves confined to an appropriately sculpted surface. In particular, we redesign three singular omnidirectional devices: the Eaton lens, the generalized Maxwell Fish-Eye, and the invisible sphere.

Transmutation of singularities and zeros in graded index optical instruments: a methodology for designing practical devices.

We describe a design methodology for modifying the refractive index profile of graded-index optical instruments that incorporate singularities or zeros in their refractive index. The process maintains the device performance whilst resulting in graded profiles that are all-dielectric, do not require materials with unrealistic values, and that are impedance matched to the bounding medium. This is achieved by transmuting the singularities (or zeros) using the formalism of transformation optics, but with an additional boundary condition requiring the gradient of the co-ordinate transformation be continuous.