Publications by authors named "Hoonchul Choi"
Article Synopsis
- Scientists are finding new ways to add useful parts to special types of chemicals called N-heteroarenes, which is important for making new medicines.
- They focused on an easy method to change a specific part of pyridine (a type of N-heteroarene) to create a product called 4-aminopyridine, which can be used in medicine.
- By using specific reactions and adjusting how the chemicals behave, they figured out a good way to get the right product every time, and they also found methods that could help with other similar chemicals.
Intramolecular alkyne hydroamidation represents a straightforward approach for the access to synthetically valuable cyclic enamides. Despite some advances made in this realm, the ability to attain a precise regiocontrol still remains challenging, especially for cyclization that leads to six-membered and larger azacyclic rings. Herein, we report a NiH-catalyzed intramolecular hydroamidation of alkynyl dioxazolones that allows for an excellent selectivity, thus affording a range of six- to eight-membered endocyclic enamides with a broad scope.
View Article and Find Full Text PDFSynthesis of heteroaryl amines has been an important topic in organic chemistry because of their importance in small-molecule discovery. In particular, 2-aminopyrimidines represent a highly privileged structural motif that is prevalent in bioactive molecules, but a general strategy to introduce the pyrimidine C2-N bonds via direct functionalization is elusive. Here we describe a synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products in situ.
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