Potential-Dependent Electrochemiluminescence for Selective Molecular Sensing of Cyanide.

Although tremendous efforts have been devoted to providing specificity for molecular sensors, most of the methods focus on the structural variation of the binding or reaction site to improve selectivity. Herein, we report a new approach in which a chemical probe, possessing a mediocre recognition site, can successfully discriminate a target among various interferences only with electrochemical manipulation. The synthetic probe () was designed to react with a cyanide anion (CN), and its dicyanovinyl group has selectivity toward CN along with sulfides and biothiols resulting in similar adducts.

Iridium(iii) complex-based electrochemiluminescent probe for HS.

Since abnormal levels of hydrogen sulphide (H2S) correlate with various diseases, simple methods for its rapid and sensitive detection are highly required. Herein, we introduce a new electrochemiluminescent probe 1 for H2S based on a cyclometalated iridium(iii) complex. o-(Azidomethyl)benzoate ester groups on the main ligands of probe 1 react selectively with H2S, resulting in cascade reactions involving H2S-mediated reduction and intramolecular cyclization/ester cleavage.

Electrogenerated Chemiluminescent Chemodosimeter Based on a Cyclometalated Iridium(III) Complex for Sensitive Detection of Thiophenol.

Thiophenol is the simplest aromatic thiol that is utilized for various applications in industry and agriculture. However, it should be used with care because thiophenol is readily absorbed into the human body by inhalation and ingestion, which leads to serious internal injuries. Thus, there is an urgent need for real-time and accurate monitoring of thiophenol.

Electrochemiluminescent chemodosimeter based on iridium(III) complex for point-of-care detection of homocysteine levels.

Elevated levels of plasma homocysteine (Hcy) are an independent risk factor for cardiovascular disease. Although a routine, rapid, and simple determination of Hcy levels is highly desired, the existing methods are practically limited because of complicated sample preparation and bulky instrumentation. Herein, we report a chemodosimetric approach for one-step analysis of Hcy levels based on the electrochemiluminescence (ECL).