Publications by authors named "Hooge M"

Article Synopsis
  • The study aimed to evaluate the reliability and validity of three questionnaires designed to assess dual-tasking difficulties in people with multiple sclerosis (PwMS).
  • A total of 356 participants across six countries were analyzed, showing that the questionnaires had strong test-retest reliability and internal consistency, with the DIDA-Q performing the best.
  • The findings indicate that these self-reported questionnaires are effective tools for measuring the impact of dual-task challenges on the daily lives of ambulatory PwMS in both research and clinical settings.
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  • The study looked at four different groups of people with chronic back pain to see if their conditions changed over 2 years.
  • They used information from doctors and tests to understand if people might switch from one group to another.
  • After 2 years, the results showed that most people stayed in the same group, meaning it's unlikely for someone to suddenly develop new signs of their condition after being checked initially.
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Objectives: This study aims to establish expert consensus recommendations for clinical information on imaging requests in suspected/known axial spondyloarthritis (axSpA), focusing on enhancing diagnostic clarity and patient care through guidelines.

Materials And Methods: A specialised task force was formed, comprising 7 radiologists, 11 rheumatologists from the Assessment of Spondyloarthritis International Society (ASAS) and a patient representative. Using the Delphi method, two rounds of surveys were conducted among ASAS members.

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Objective: Radiographic assessment of sacroiliac joints (SIJs) according to the modified New York (mNY) criteria is key in the classification of axial spondyloarthritis but has moderate interreader agreement. We aimed to investigate the improvements of the reliability in scoring SIJ radiographs after applying an online real-time iterative calibration (RETIC) module, in addition to a slideshow and video alone.

Methods: Nineteen readers, randomized to 2 groups (A or B), completed 3 calibration steps: (1) review of manuscripts, (2) review of slideshow and video with group A completing RETIC, and (3) re-review of slideshow and video with group B completing RETIC.

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Article Synopsis
  • The study examines the participation of junior members and other representative roles in the European Alliance of Associations for Rheumatology (EULAR) task forces, comparing their experiences to traditional task force members.
  • An online survey was conducted, revealing that a significant portion of junior members felt unprepared and uncertain about their roles, highlighting a gap in engagement compared to traditional members.
  • The findings suggest that effective onboarding and clarification of roles by the convenor can enhance the participation and confidence of junior members, patients, and health professionals in task forces.
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Whereas previous projects attempted to standardize imaging in patients with axial spondyloarthritis (axSpA), few studies have been published about the need for specific details regarding the image acquisition and lesions that may be less familiar to general radiologists. This work reports consensus recommendations developed by the Assessment of SpondyloArthritis International Society (ASAS) that aim to standardize the imaging reports in patients suspected of having or with known axSpA. A task force consisting of radiologists and rheumatologists from ASAS and one patient representative formulated two surveys that were completed by ASAS members.

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Objectives: To assess the association of posterior element (PE) and facet joint (FJ) inflammation with subsequent new FJ ankylosis (FJA) on MRI, in patients with radiographic axial spondyloarthritis (r-axSpA).

Methods: Patients from the Sensitive Imaging in Ankylosing Spondylitis cohort, inclusion criteria r-axSpA and ≥1 radiographic spinal syndesmophyte, were studied. MRI of the full spinal was performed at baseline, 1 and 2 years.

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Article Synopsis
  • This review highlights recent advancements in disease-modifying therapies for axial spondyloarthritis (axSpA).
  • It discusses conflicting findings regarding the effectiveness of NSAIDs, TNF inhibitors, IL-17 inhibitors, and JAK inhibitors in slowing structural progression of the disease.
  • The review suggests that ongoing research and improved imaging techniques are necessary to better understand the impact of these therapies on disease outcomes over time.
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  • People with progressive multiple sclerosis (PMS) often experience both motor and cognitive fatigue, affecting their ability to walk and think effectively.
  • A study involving 298 PMS patients revealed that over half exhibited walking fatigability (WF), while two-thirds showed cognitive fatigability (CF), with WF linked to worse clinical outcomes and higher levels of fatigue.
  • Despite both kinds of fatigue being prevalent, the extent of cognitive and walking fatigability was not strongly associated, indicating that different factors may influence them in PMS patients.
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Objectives: To evaluate sacroiliac radiographic progression over a 10-year follow-up and determine the baseline factors associated with such progression in patients with recent-onset axial spondyloarthritis (axSpA, <3 years).

Methods: This analysis was performed in the DESIR cohort (NCT01648907). The radiographic status of the patients (radiographic axSpA (r-axSpA) vs non-radiographic axSpA (nr-axSpA)) was based on the modified New York (mNY) criteria.

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Article Synopsis
  • - The study compares the ability of MRI and radiographs to detect erosions in the sacroiliac joint (SIJ) for patients with recent-onset axial spondyloarthritis (axSpA) over a 104-week period, with a focus on the effects of the treatment etanercept. - Results showed that MRI detected more erosions than radiographs at baseline and in changes over time, with a significant number of patients demonstrating improved erosion scores on MRI compared to radiographs after treatment. - The research highlights that MRI may be superior in monitoring SIJ erosions in axSpA, suggesting that further investigation into the clinical significance of these findings is needed.
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Background: The Spondyloarthritis Research Consortium of Canada (SPARCC) developers have created web-based calibration modules for the SPARCC MRI sacroiliac joint (SIJ) scoring methods. We aimed to test the impact of applying these e-modules on the feasibility and reliability of these methods.

Methods: The SPARCC-SIJ e-modules contain cases with baseline and follow-up scans and an online scoring interface.

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Background: The Computed Tomography Syndesmophyte Score (CTSS) was developed as a reliable and sensitive tool to assess syndesmophytes in low-dose CT images of the entire spine in patients with axial spondyloarthritis (axSpA). The original paper provided sparce examples of the CTSS grades.

Objectives: Provide an atlas tailored to assist readers in understanding and employing the CTSS method.

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Magnetic resonance imaging (MRI) has emerged as a valuable tool for early detection and of axial spondyloarthritis (axSpA). A standardized imaging acquisition protocol, aligned with the current state-of-the-art, is crucial to obtain MRI scans that meet the diagnostic quality requirements. It is important to note that certain lesions, particularly bone marrow edema (BME), can be induced by mechanical stress or be a manifestation of another non-inflammatory disorder and may mimic the characteristic findings of axSpA on MRI.

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Objectives: Investigating the association between different definitions of axial involvement and syndesmophytes development over 2 years in patients with psoriatic arthritis (PsA).

Methods: Patients from a prospective multicentre cohort (Belgian Epidemiological Psoriatic Arthritis Study) involving 17 Belgian rheumatology practices were recruited between December 2012 and July 2014 and included when fulfilling the Classification Criteria for Psoriatic Arthritis. Axial involvement included six clinical and two radiographic oriented definitions.

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Kinase inhibitors have revolutionized cancer treatment in the past 25 years and currently form the cornerstone of many treatments. Due to the increasing evidence for therapeutic drug monitoring (TDM) of kinase inhibitors, the need is growing for new assays to rapidly evaluate kinase inhibitor plasma concentrations. In this study, we developed an LC-MS/MS assay for the rapid and simultaneous quantification of 21 kinase inhibitors.

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Objective: To determine the prevalence of sacroiliac joint variants in patients with axial spondyloarthritis (axSpA) using MRI-based synthetic CT images and to evaluate their relationships with the presence of bone marrow edema, as this may potentially complicate diagnosing active sacroiliitis on MRI in patients with suspected axSpA.

Methods: 172 patients were retrospectively included. All patients underwent MRI because of clinical suspicion of sacroiliitis.

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Objective: To investigate sex differences in spinal radiographic progression in axial spondyloarthritis (axSpA).

Methods: AxSpA patients in the Swiss Clinical Quality Management cohort with available spinal radiographs every 2 years were included. Paired radiographs were scored by two readers according to the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS).

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Objective: We aimed to develop and validate a fully automated machine learning (ML) algorithm that predicts bone marrow edema (BME) on a quadrant level in sacroiliac (SI) joint magnetic resonance imaging (MRI).

Methods: A computer vision workflow automatically locates the SI joints, segments regions of interest (ilium and sacrum), performs objective quadrant extraction, and predicts presence of BME, suggestive of inflammatory lesions, on a quadrant level in semicoronal slices of T1/T2-weighted MRI scans. Ground truth was determined by consensus among human readers.

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Article Synopsis
  • This study aimed to investigate how much vertebral corner fat accumulation contributes to the formation of syndesmophytes in patients with radiographic axial spondyloarthritis (r-axSpA).
  • Researchers analyzed data from two cohorts, assessing inflammation and fat deposition at multiple time points and using imaging techniques to evaluate the development of syndesmophytes.
  • The results indicated that while inflammation increased the likelihood of syndesmophyte formation, only a small fraction of that effect was explained by fat deposition at the vertebral corners.
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Objective: As anaemia represents a biomarker for increased radiographic damage in rheumatoid arthritis, we aimed to investigate whether it independently predicts spinal radiographic progression in axial spondyloarthritis (axSpA).

Methods: AxSpA patients with available haemoglobin levels from the prospective Swiss Clinical Quality Management Registry were included for comparison of patients with and without anaemia. Spinal radiographic progression was assessed according to the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) in patients with ankylosing spondylitis (AS) if ≥ 2 sets of spinal radiographs were available every 2 years.

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Background: To examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices.

Methods: Patients with PsA with clinical diagnosis of PsA and fulfilling the Classification Criteria for Psoriatic Arthritis from the prospective Belgian Epidemiological Psoriatic Arthritis Study and patients with SpA fulfilling the Assessment of SpondyloArthritis international Society classification criteria for SpA originate from the Ghent and BelGian Inflammatory Arthritis and spoNdylitis cohorTs were included in this study. Baseline pelvic and spinal radiographs were analysed by two calibrated readers.

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Background And Objective: Ruxolitinib is a tyrosine kinase inhibitor targeting the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways. Ruxolitinib is used to treat myelofibrosis, polycythemia vera and steroid-refractory graft-versus-host disease in the setting of allogeneic stem-cell transplantation. This review describes the pharmacokinetics and pharmacodynamics of ruxolitinib.

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Introduction: Understanding the pharmacokinetics (PK) of antimicrobial drugs in pregnant women is crucial to provide effective and safe treatment. This study is part of a series that systematically reviews literature on the PK and analyzes if, based on the changed PK, evidence-based dosing regimens have been developed for adequate target attainment in pregnant women. This part focusses on antimicrobials other than penicillins and cephalosporins.

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Objectives: To analyse whether time-varying treatment with tumour necrosis factor inhibitors (TNFi) in radiographic axial spondyloarthritis (r-axSpA) has a differential impact on structural damage progression on different spinal segments (cervical versus lumbar spine).

Methods: Patients with r-axSpA in the Swiss Clinical Quality Management cohort were included if cervical and lumbar radiographs were available at intervals of 2 years for a maximum of 10 years. Paired radiographs were scored by two calibrated readers according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS).

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