Publications by authors named "Hood Salleh"
The human cytochrome P450 (CYP) is a superfamily of enzymes that have been a focus in research for decades due to their prominent role in drug metabolism. CYP2C is one of the major subfamilies which metabolize more than 10% of all clinically used drugs. In the context of CYP2C19, several key genetic variations that alter the enzyme's activity have been identified and catalogued in the CYP allele nomenclature database.
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- A study characterized CYP2C9 gene variants in 61 Orang Asli and 96 Singaporean Malays using whole genome sequencing and compared these with 11 other populations.
- The Orang Asli showed the highest frequency of the CYP2C9*3 variant and had three clinically significant alleles, suggesting they might need lower drug doses due to reduced metabolic capacity.
- The findings highlighted differences in genetic patterns among populations and underscored the importance of understanding genetic variations for better precision medicine in the Orang Asli.
Pigmentation is a readily scorable and quantitative human phenotype, making it an excellent model for studying multifactorial traits and diseases. Convergent human evolution from the ancestral state, darker skin, towards lighter skin colors involved divergent genetic mechanisms in people of European vs. East Asian ancestry.
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