Effects of YAP Inhibitors and Activators on the Growth of Leukemia Cells.

Background/aim: The Hippo signaling pathway is involved in cell proliferation through the regulation of its downstream molecule YAP. The dysregulation of Hippo signaling is associated with cancer cell proliferation. This study aimed to investigate the effects of YAP inhibitors and activators on the proliferation of human leukemia cell lines to examine whether YAP functions as a tumor suppressor or promoter.