Publications by authors named "Honoka Ogawa"
Article Synopsis
- - A new group of inhibitors designed to target the mitotic motor protein CENP-E was developed using a chemical method that combines 1,3-diketones with different hydrazines under gentle conditions.
- - The research successfully explored how the structure of the pyrazole photoswitch affects the activity of these CENP-E inhibitors in lab tests (in vitro) and living cells.
- - This study enhances our understanding of how these inhibitors work and their potential applications in biological systems.
The pyridoxal 5'-phosphate (PLP)-binding protein (PLPBP) plays an important role in vitamin B homeostasis. Loss of this protein in organisms such as Escherichia coli and humans disrupts the vitamin B pool and induces intracellular accumulation of pyridoxine 5'-phosphate (PNP), which is normally undetectable in wild-type cells. This accumulated PNP could affect diverse metabolic systems through the inhibition of some PLP-dependent enzymes.
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