Publications by authors named "Honoka Nishi"
Biomed Pharmacother
October 2024
Article Synopsis
- Fluoroquinolones, common antibiotics, have been linked to aortic disease, leading to an FDA warning, but recent studies challenge this risk perception.
- The study focused on levofloxacin's impact on aortic dissection through both lab tests and mouse models, revealing endothelial cell damage in vitro but no significant increase in aortic dissection risk in vivo.
- Overall, despite some harmful effects observed in lab settings, the research concludes that fluoroquinolones do not significantly increase the risk of aortic dissection in clinical practice, suggesting their continued use is safe while recommending further studies for clarity.
Biomed Pharmacother
November 2023
Article Synopsis
- A study was conducted to explore the unclear relationship between angiogenesis inhibitors (cancer drugs) and the risk of aortic dissection, using a combination of lab mice, cultured cells, and real-world data.
- Results indicated that angiogenesis inhibitors, unlike other hypertension drugs, significantly increased the risk of aortic aneurysms and dissection, especially in patients with a history of atherosclerosis and dyslipidemia.
- In mouse models treated with the drug sunitinib, there was an increase in both blood pressure and instances of aortic dissection, linked to endothelial cell damage and higher levels of a harmful molecule called endothelin-1, highlighting the need for safer cancer treatments.
