Miniaturized spectral sensing with a tunable optoelectronic interface.

Reconstructive optoelectronic spectroscopy has generated substantial interest in the miniaturization of traditional spectroscopic tools, such as spectrometers. However, most state-of-the-art demonstrations face fundamental limits of rank deficiency in the photoresponse matrix. In this work, we demonstrate a miniaturized spectral sensing system using an electrically tunable compact optoelectronic interface, which generates distinguishable photoresponses from various input spectra, enabling accurate spectral identification with a device footprint of 5 micrometers by 5 micrometers.

The Effects of Virtual Reality Training on Cognition in Older Adults: A Systematic Review, Meta-Analysis, and Meta-Regression of Randomized Controlled Trials.

The aim of this systematic review, meta-analysis, and meta-regression was to examine the effects of virtual reality-based training on global cognition and executive function compared with conventional training or information-based treatment in older adults, regardless of cognitive level. A systematic literature search was conducted using four databases. A total of 31 randomized controlled trials were identified.

Applications of Synthetic Pentatricopeptide Repeat Proteins.

RNA-binding proteins play integral roles in the regulation of essential processes in cells and as such are attractive targets for engineering to manipulate gene expression at the RNA level. Expression of transcripts in chloroplasts and mitochondria is heavily regulated by pentatricopeptide repeat (PPR) proteins. The diverse roles of PPR proteins and their naturally modular architecture make them ideal candidates for engineering.

Interaction during equine-facilitated rehabilitation from the rehabilitees' perspective - A phenomenological study.

Introduction: Interaction has a multidimensional role in equine-facilitated rehabilitation.

Purpose: The aim of this study was to understand rehabilitees' experiences of interaction during equine-facilitated rehabilitation.

Methods: Six children and four adults with individual diagnoses or reasons to participate in equine-facilitated rehabilitation were included in this qualitative study.

The GENOMES UNCOUPLED1 protein has an ancient, highly conserved role but not in retrograde signalling.

The pentatricopeptide repeat protein GENOMES UNCOUPLED1 (GUN1) is required for chloroplast-to-nucleus signalling when plastid translation becomes inhibited during chloroplast development in Arabidopsis thaliana, but its exact molecular function remains unknown. We analysed GUN1 sequences in land plants and streptophyte algae. We tested functional conservation by complementation of the Arabidopsis gun1 mutant with GUN1 genes from the streptophyte alga Coleochate orbicularis or the liverwort Marchantia polymorpha.

Cofactor-independent RNA editing by a synthetic S-type PPR protein.

Pentatricopeptide repeat (PPR) proteins are RNA-binding proteins that are attractive tools for RNA processing in synthetic biology applications given their modular structure and ease of design. Several distinct types of motifs have been described from natural PPR proteins, but almost all work so far with synthetic PPR proteins has focused on the most widespread P-type motifs. We have investigated synthetic PPR proteins based on tandem repeats of the more compact S-type PPR motif found in plant organellar RNA editing factors and particularly prevalent in the lycophyte .

Microtubule associated protein WAVE DAMPENED2-LIKE (WDL) controls microtubule bundling and the stability of the site of tip-growth in Marchantia polymorpha rhizoids.

Tip-growth is a mode of polarized cell expansion where incorporation of new membrane and wall is stably restricted to a single, small domain of the cell surface resulting in the formation of a tubular projection that extends away from the body of the cell. The organization of the microtubule cytoskeleton is conserved among tip-growing cells of land plants: bundles of microtubules run longitudinally along the non-growing shank and a network of fine microtubules grow into the apical dome where growth occurs. Together, these microtubule networks control the stable positioning of the growth site at the cell surface.

Novel methods for cold exposure of skeletal muscle in vivo and in vitro show temperature-dependent myokine production.

Proteins secreted from skeletal muscle serving a signalling role have been termed myokines. Many of the myokines are exercise factors, produced and released in response to muscle activity. Cold exposures affecting muscle may occur in recreational, occupational and therapeutic settings.

A synthetic RNA editing factor edits its target site in chloroplasts and bacteria.

Members of the pentatricopeptide repeat (PPR) protein family act as specificity factors in C-to-U RNA editing. The expansion of the PPR superfamily in plants provides the sequence variation required for design of consensus-based RNA-binding proteins. We used this approach to design a synthetic RNA editing factor to target one of the sites in the Arabidopsis chloroplast transcriptome recognised by the natural editing factor CHLOROPLAST BIOGENESIS 19 (CLB19).

The presence of lupus nephritis additionally increases the risk of preeclampsia among pregnant women with systemic lupus erythematosus.

Introduction: Pregnant women with systematic lupus erythematosus (SLE) have an increased risk of obstetric complications, such as preeclampsia and premature births. Previous studies have suggested that renal involvement could further increase the risk for adverse obstetric outcomes. The aim of this study was to compare the obstetric outcomes in a Swedish cohort of patients with SLE with and without lupus nephritis (LN).

Fabrication of buried nanostructures by atomic layer deposition.

We present a method for fabricating buried nanostructures by growing a dielectric cover layer on a corrugated surface profile by atomic layer deposition of TiO. Selecting appropriate process parameters, the conformal growth of TiO results in a smooth, nearly flat-top surface of the structure. Such a hard surface can be easily cleaned without damage, making the nanostructure reusable after contamination.

Negative regulation of conserved class I bHLH transcription factors evolved independently among land plants.

Basic helix-loop-helix transcription factors encoded by class I genes control a gene regulatory network that positively regulates the development of filamentous rooting cells - root hairs and rhizoids - in land plants. The GLABRA2 transcription factor negatively regulates these genes in the angiosperm . To find negative regulators of class I genes in early diverging land plants we conducted a mutant screen in the liverwort .

Silicon slot waveguide Fano resonator.

The growing interest for Fano resonators during the past decade is due to the narrow line shape observable in their optical spectra. The drastic phase shift occurring at the resonance yields a steep drop from a high to low amplitude. Fano resonances can be obtained by a combination of nanostructures.

Multi-wavelength add-drop filter with phase-modulated shifted Bragg grating.

We present, for the first time to the best of our knowledge, a multichannel add-drop operation with a phase-modulated shifted Bragg grating based filter. The device is realized in a silicon-on-insulator waveguide platform with TiO as a coating material to reduce the refractive index contrast. The operation is shown for three and five wavelength channels within the telecom C-band.

Multi-wavelength filtering with a waveguide integrated phase-modulated Bragg grating.

We present a multi-wavelength band-rejection filter on a titanium dioxide-coated silicon-on-insulator platform. The concept rests on the use of a finely tuned waveguide-based Bragg grating for which the periods are slightly varied from one to another. This phase-modulated Bragg grating enables precise customization of integrated waveguide filters.

Influence of an AlO surface coating on the response of polymeric waveguide sensors.

The responses of a polymer ridge waveguide Young interferometer with and without a bilayer of AlO/TiO, fabricated by atomic layer deposition, are studied and compared when applied as an aqueous chemical sensor. The phase shift of the guided mode, as a result of the change in refractive index of the cover medium, is monitored. The results indicate that the over-coating affects the linearity of the sensor response.

Strip-loaded waveguide on titanium dioxide thin films by nanoimprint replication.

We present a convenient, low-cost, and mass-production-compatible technique for the fabrication of strip-loaded waveguides. The technique is based on the atomic layer deposition of a slab waveguide, nanoimprinting of a strip, and integration of two structures by lamination. The guiding layer is chosen to be a 200 nm thick titanium dioxide film.

Strip-loaded horizontal slot waveguide.

We introduce a novel concept for an optical waveguide called a strip-loaded slot waveguide. It allows an extraordinary confinement of the field in a waveguide with an extremely tiny (vertical) cross section. Unlike conventional slot waveguides, the proposed configuration has potential for very low propagation losses.

The Mechanism Forming the Cell Surface of Tip-Growing Rooting Cells Is Conserved among Land Plants.

To discover mechanisms that controlled the growth of the rooting system in the earliest land plants, we identified genes that control the development of rhizoids in the liverwort Marchantia polymorpha. 336,000 T-DNA transformed lines were screened for mutants with defects in rhizoid growth, and a de novo genome assembly was generated to identify the mutant genes. We report the identification of 33 genes required for rhizoid growth, of which 6 had not previously been functionally characterized in green plants.

Add-drop filter based on TiO coated shifted Bragg grating.

We present a titanium dioxide coated shifted Bragg grating in a silicon-on-insulator platform enabling optical add-drop functionality. The device works on the basis of mode conversion due to shifted sidewall structure followed by mode splitting based on an asymmetric Y-coupler. We experimentally demonstrate the working principle of the device.

Growth regulation in tip-growing cells that develop on the epidermis.

Plants develop tip-growing extensions-root hairs and rhizoids-that initiate as swellings on the outer surface of individual epidermal cells. A conserved genetic mechanism controls the earliest stages in the initiation of these swellings. The same mechanism controls the formation of multicellular structures that develop from swellings on epidermal cells in early diverging land plants.

Hybrid layered polymer slot waveguide Young interferometer.

We demonstrate a polymer slot waveguide Young interferometer coated with a bilayer of AlO/TiO. The approach enables relaxed dimensions of the polymer waveguide which simplifies the fabrication of the structure with a resolution of 50 nm. The layers were coated by an atomic layer deposition technique.

Slow-light enhanced electro-optic modulation with an on-chip silicon-hybrid Fano system.

We present the theoretical study of a coupled cavity system yielding a Fano response on a fully on-chip silicon platform hybridized with an electro-optic polymer. This novel Fano system is based on a slot waveguide Bragg grating geometry, enabling a huge enhancement of the electro-optic properties due to slow light effects at the resonance. The modulator shows a high resonance tunability of 1.

Pyrolytic carbon coated black silicon.

Carbon is the most well-known black material in the history of man. Throughout the centuries, carbon has been used as a black material for paintings, camouflage, and optics. Although, the techniques to make other black surfaces have evolved and become more sophisticated with time, carbon still remains one of the best black materials.