Publications by authors named "Hongyun Zhang"

Article Synopsis
  • Liver cancer is a leading cause of cancer mortality globally, with traditional Chinese medicine, particularly Huaier polysaccharides (HP), being used as a potential treatment strategy.
  • HP demonstrated limited effectiveness against human and mouse HCC cells in vitro, but showed stronger anti-HCC effects in animal models, largely mediated by macrophage activity.
  • The study found that HP alters gut microbiota and enhances pro-inflammatory responses while affecting M2 macrophage polarization, suggesting the importance of gut microbiota in HP's efficacy against liver cancer.
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Background: Cervical cancer is a major health threat in the female population. Human immunodeficiency virus (HIV)-positive women encounter a higher risk of cervical cancer. It is significant to promote cervical cancer screening attendance among HIV-positive women.

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Strong light-matter interaction provides opportunities for tailoring the physical properties of quantum materials on the ultrafast timescale by forming photon-dressed electronic states, i.e., Floquet-Bloch states.

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Zearalenone (ZEA) is a widely distributed mycotoxin that presents a substantial worldwide health risk to animals. Several natural compounds have shown promise in mitigating the detrimental impacts of ZEA. This study examined the detoxification potential of previously identified compounds by utilizing zebrafish embryos as a model organism.

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Symmetry breaking plays an important role in the fields of physics, ranging from particle physics to condensed matter physics. In solid-state materials, phase transitions are deeply linked to the underlying symmetry breakings, resulting in a rich variety of emergent phases. Such symmetry breakings are often induced by controlling the chemical composition and temperature or applying an electric field, strain, etc.

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Litopenaeus vannamei is a crucial species in aquaculture. The gene expression patterns associated with distinct growth rates are not well understood. To investigate this, we used RNA-seq to study the underlying growth mechanism of L.

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Background: Fracture healing can be impeded or even compromised by various factors, resulting in a growing number of patients suffering. The lncRNA LINC-PINT has garnered attention for its latent role in enhancing fracture healing, but its specific functions in this process remain unclear.

Objectives: The primary objective of this study is to investigate the clinical relevance and underlying molecular mechanisms of LINC-PINT in delayed fracture healing (DFH), while also assessing its potential as an early diagnostic biomarker.

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Flat bands and nontrivial topological physics are two important topics of condensed matter physics. With a unique stacking configuration analogous to the Su-Schrieffer-Heeger model, rhombohedral graphite (RG) is a potential candidate for realizing both flat bands and nontrivial topological physics. Here, we report experimental evidence of topological flat bands (TFBs) on the surface of bulk RG, which are topologically protected by bulk helical Dirac nodal lines via the bulk-boundary correspondence.

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Article Synopsis
  • - The study conducted expanded carrier screening (ECS) on 3024 individuals from southern and southwestern China to assess the prevalence of recessively inherited genetic disorders and enhance reproductive advice.
  • - Results showed that 62.3% of participants carried pathogenic or likely pathogenic variants, with a significant portion being carriers of multiple diseases, indicating a high carrier frequency in the population.
  • - The findings support the effectiveness of ECS in identifying genetic carriers and provide valuable data for couples at risk, improving potential reproductive outcomes.
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Introduction: Oxidative stress and neuroapoptosis are significant pathological processes that occur in response to intracerebral hemorrhage (ICH), however, the optimal therapeutic strategy to treat these responses remains unknown. Pterostilbene (PTE) influences neural cell survival in in the pathology of a number of neurological diseases, but the mechanisms underlying this influence at present are not clear. The objective of the present study was to examine the potential impact of PTE on mitigating oxidative stress and neuronal apoptosis following ICH, while also elucidating the potential underlying pathways.

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Background: The present study is to evaluate the clinical characteristics of patients with temporomandibular disorders (TMD).

Methods: A total of 3362 TMD patients were included. Each participant had complete medical records according to the diagnostic criteria for temporomandibular disorders (DC/TMD).

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Dendrobine (DDB), an alkaloid isolated from the Chinese herb Dendrobium, has antioxidant and anti-inflammatory effects; however, whether DDB reduces oleic acid (OA)-induced lipid accumulation remains unclear. OA-induced lipid accumulation model of HepG2 cells were treated with DDB. Cellular lipid deposition was assessed by Oil Red O (ORO) staining and triglyceride and total cholesterol detection.

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Background: Syndecan 4 (SDC4), a type I transmembrane proteoglycan, serves as a critical link between chondrocytes and the extracellular matrix.

Objective: This study aimed to explore the role of SDC4 in cartilage degeneration of temporomandibular joint osteoathritis (TMJOA).

Methods: Condylar chondrocytes were stimulated with varying concentrations of recombinant rat interleukin-1β (rrIL-1β) and SDC4 small interfering RNA (si-SDC4).

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AR495 is a widely used probiotic for the treatment of various digestive diseases, including irritable bowel syndrome (IBS). However, the specific mechanisms of AR495 in alleviating IBS remain unclear. Abnormal intestinal tryptophan metabolism can cause disordered immune responses, gastrointestinal peristalsis, digestion and sensation, which is closely related to IBS pathogenesis.

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Article Synopsis
  • - Rabies virus (RABV) causes a deadly neurological disease and has five structural proteins, with research showing Apolipoprotein D (ApoD) is upregulated in the nervous system after injury.
  • - This study found that after RABV infection, ApoD levels increased in mouse brains and specific cells, suggesting its role in virus behavior.
  • - It was discovered that ApoD enhances RABV replication by interacting with the virus's glycoprotein and potentially upregulating cholesterol levels, indicating a new target for rabies treatments.
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Background: Rectus abdominis separation (DRA) affects pelvic stability and body image. No studies have explored the effects of manual massage on early postpartum DRA and postpartum depression.

Aim: To analyze the curative effect of massage on early postpartum DRA and its impact on postpartum depression and thus its ability promote the overall psychosomatic rehabilitation of postpartum women.

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Topological Dirac nodal-line semimetals host topologically nontrivial electronic structure with nodal-line crossings around the Fermi level, which could affect the photocarrier dynamics and lead to novel relaxation mechanisms. Herein, by using time- and angle-resolved photoemission spectroscopy, we reveal the previously inaccessible linear dispersions of the bulk conduction bands above the Fermi level in a Dirac nodal-line semimetal PtSn, as well as the momentum and temporal evolution of the gapless nodal lines. A surprisingly ultrafast relaxation dynamics within a few hundred femtoseconds is revealed for photoexcited carriers in the nodal line.

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Twisted bilayer graphene (tBLG) provides a fascinating platform for engineering flat bands and inducing correlated phenomena. By designing the stacking architecture of graphene layers, twisted multilayer graphene can exhibit different symmetries with rich tunability. For example, in twisted monolayer-bilayer graphene (tMBG) which breaks the C symmetry, transport measurements reveal an asymmetric phase diagram under an out-of-plane electric field, exhibiting correlated insulating state and ferromagnetic state respectively when reversing the field direction.

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Person re-identification (ReID) typically encounters varying degrees of occlusion in real-world scenarios. While previous methods have addressed this using handcrafted partitions or external cues, they often compromise semantic information or increase network complexity. In this paper, we propose a new method from a novel perspective, termed as OAT.

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Magic-angle twisted bilayer graphene exhibits correlated phenomena such as superconductivity and Mott insulating states related to the weakly dispersing flat band near the Fermi energy. Such a flat band is expected to be sensitive to both the moiré period and lattice relaxations. Thus, clarifying the evolution of the electronic structure with the twist angle is critical for understanding the physics of magic-angle twisted bilayer graphene.

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Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the nucleoid-associated protein Lsr2. We show that c-di-GMP specifically binds to Lsr2 at a ratio of 1:1.

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Article Synopsis
  • * A study on female rats with induced OA in their temporomandibular joints showed increased adipogenesis in chondrocytes and reduced ABCG1 expression in affected cartilage.
  • * Overexpressing ABCG1 in chondrocytes countered the abnormal adipogenesis caused by mechanical stress, suggesting that boosting ABCG1 may help protect cartilage during OA.
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Time-periodic light field can dress the electronic states and lead to light-induced emergent properties in quantum materials. While below-gap pumping is regarded favorable for Floquet engineering, so far direct experimental evidence of momentum-resolved band renormalization still remains missing. Here, we report experimental evidence of light-induced band renormalization in black phosphorus by pumping at photon energy of 160 meV, which is far below the band gap, and the distinction between below-gap pumping and near-resonance pumping is revealed.

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  • A fetus with isolated bilateral MV was diagnosed with Snijders Blok-Fisher syndrome due to a genetic variant identified through whole-exome sequencing, despite negative results from other genetic tests.
  • The infant born from this pregnancy experienced delayed motor development and showed brain abnormalities, highlighting the importance of advanced genetic testing and imaging in cases of isolated MV to avoid misdiagnosis.
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