The Application of Rat Models in Infections.

() is a major human pathogen and can cause a wide range of diseases, including pneumonia, osteomyelitis, skin and soft tissue infections (SSTIs), endocarditis, mastitis, bacteremia, and so forth. Rats have been widely used in the field of infectious diseases due to their unique advantages, and the models of infections have played a pivotal role in elucidating their pathogenic mechanisms and the effectiveness of therapeutic agents. This review outlined the current application of rat models in infections and future prospects for rat models in infectious diseases caused by .

The Changes of Blood and CSF Ion Levels in Depressed Patients: a Systematic Review and Meta-analysis.

Micronutrient deficiencies and excesses are closely related to developing and treating depression. Traditional and effective antidepressants include tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and lithium. There is no consensus on the fluctuation of zinc (Zn), magnesium (Mg), calcium (Ca), copper (Cu), iron (Fe), and manganese (Mn) ion levels in depressed individuals before and after therapy.

Dynamic Changes in Soil Phosphorus Accumulation and Bioavailability in Phosphorus-Contaminated Protected Fields.

Soil phosphorus accumulation resulting in a high risk of phosphorus pollution is due to high multiple vegetable cropping indexes and excessive fertilizer input in protected fields. Therefore, this study explored the bioavailability of soil-accumulated phosphorus to improve fertilization and reduce the risk of soil phosphorus contamination in protected fields. A field trial was performed in Yanbian Prefecture, China to study the phosphorus bioavailability after continuous spinach planting without phosphate fertilizer applications.

Mechanism of cell death pathways in status epilepticus and related therapeutic agents.

The most severe form of epilepsy, status epilepticus (SE), causes brain damage and results in the development of recurring seizures. Currently, the management of SE remains a clinical challenge because patients do not respond adequately to conventional treatments. Evidence suggests that neural cell death worsens the occurrence and progression of SE.

Ca-activated Cl channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells.

Introduction: Ca-activated Cl channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension. It remains unclear whether TMEM16A regulates endothelial angiogenesis, which participates in many physiological and pathological processes. Cholesterol regulates many ion channels including TMEM16A, and high cholesterol levels contribute to endothelial dysfunction.

A bibliometric analysis and review of recent researches on TRPM7.

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed protein that contains both an ion channel and an active kinase. TRPM7 has involved in a variety of cellular functions and critically participates in various diseases mainly including cancer and neurodegenerative disorders. However, the theme trends and knowledge structures for TRPM7 have not yet been studied bibliometrically.