Filamentous Actin in the Nucleus in Triple-Negative Breast Cancer Stem Cells: A Key to Drug-Induced Nucleolar Stress and Stemness Inhibition?

Actin, primarily a cytoplasmic cytoskeleton protein, is transported in and out of the nucleus with the help of actin-binding proteins (ABPs). Actin exists in two forms, i.e.

Optimized terahertz generation in BNA organic crystals with chirped Ti:sapphire laser pulses.

We report on the efficient generation of intense terahertz radiation from the organic crystal N-benzyl-2-methyl-4-nitroaniline pumped by chirped Ti:sapphire femtosecond laser pulses. The THz energy and spectrum as a function of the pump fluence and duration of the chirped laser pulses are studied systematically. For the appropriate positively chirped pump pulses, a significant boost in the THz generation efficiency by a factor of around 2.

Association of serum fatty acid pattern with depression in U.S. adults: analysis of NHANES 2011-2012.

Background: Exposure to different concentration levels of fatty acids (FAs) may have an impact on depression. However, previous studies using individual FAs may not reflect the performance of mixtures of various FAs, and the associations of FA patterns with depression remain unclear.

Methods: We conducted the cross-sectional analysis in 792 adults aged 18 and older with available serum FAs and depression screening data in the National Health and Nutrition Examination Survey (NHANES) 2011-2012.

Model-free robust motion control for biological optical microscopy using time-delay estimation with an adaptive RBFNN compensator.

The field of large numerical aperture microscopy has witnessed significant advancements in spatial and temporal resolution, as well as improvements in optical microscope imaging quality. However, these advancements have concurrently raised the demand for enhanced precision, extended range, and increased load-bearing capacity in objective motion carrier (OMC). To address this challenge, this study introduces an innovative OMC that employs a ball screw mechanism as its primary driving component.

Construction of Hierarchical Conductive Networks for LiNiMnCoO Cathode toward Stable Cycling at High Areal Mass Loadings.

Realizing high-performance thick electrodes is considered as a practical strategy to promote the energy density of lithium-ion batteries. However, establishing effective transport pathways for both lithium-ions and electrons in a thick electrode is very challenging. This study develops a hierarchical conductive network structure for constructing high-performance NMC811 (LiNiMnCoO) cathode toward stable cycling at high areal mass loadings.

Pd nanoparticles decorated ultrathin 2D metal-organic framework nanosheets with enhanced peroxidase-mimic activity and colorimetric assay of glucose.

In addition to size, shape and morphology, enzyme-mimetic property could be efficiently regulated by controlling composition, forming complexes or hybrids, and surface modification. Herein, Pd nanoparticles with an average diameter of 2.52 nm were decorated on ultrathin 2D copper(ii)-porphyrin derived metal-organic framework (MOF) nanosheets by a simple reduction method for catalytic activity regulation.

Exploration of novel clusters and prognostic value of immune‑related signatures and identify HAMP as hub gene in colorectal cancer.

Immune checkpoint inhibitors currently serve an important role in prolonging patients' overall survival. However, the prognostic signatures of immune checkpoint inhibitors in colorectal cancer (CRC) remain uncertain and more knowledge on the genetic characteristics of colorectal cancer is needed. Patients with CRC from The Cancer Genome Atlas were classified into high-immunity group and low-immunity group based on median scores from single-sample gene set enrichment analysis using the GSVA package.

Two dimensional iron metal-organic framework nanosheet with peroxidase-mimicking activity for colorimetric detection of hypoxanthine related to shrimp freshness.

Two dimensional iron metal-organic framework nanosheet (2D Fe MOF) was facilely synthesized at room temperature by simple stirring of iron salts and terephthalic acid ligand in a mixed solution containing triethylamine. Its morphology and structure were fully characterized by TEM, AFM, XPS and TEM element mapping. Then, its peroxidase-mimicking activity was studied by using HO and 3, 3', 5, 5'- tetramethylbenzidine as substrate.

HISTONE DEACETYLASE 9 transduces heat signal in plant cells.

Heat stress limits plant growth, development, and crop yield, but how plant cells precisely sense and transduce heat stress signals remains elusive. Here, we identified a conserved heat stress response mechanism to elucidate how heat stress signal is transmitted from the cytoplasm into the nucleus for epigenetic modifiers. We demonstrate that HISTONE DEACETYLASE 9 (HDA9) transduces heat signals from the cytoplasm to the nucleus to play a positive regulatory role in heat responses in .

Metalloporphyrin and gold nanoparticles modified hollow zeolite imidazole Framework-8 with excellent peroxidase like activity for quick colorimetric determination of choline in infant formula milk powder.

Metalloporphyrin and gold nanoparticles (AuNPs) were fixed on the surface of hollow zeolite imidazole framework-8 (HZIF-8) by cation exchange and cross-linking reaction. The obtained hybrid nanozyme, Au/HZIF-8@TCPP(Fe), was fully characterized by TEM, HRTEM, EDS element mapping and XPS. Then, its peroxidase-like activity was explored with Km of 1.

Ultrasmall Au nanoparticles modified 2D metalloporphyrinic metal-organic framework nanosheets with high peroxidase-like activity for colorimetric detection of organophosphorus pesticides.

Ultrasmall Au nanoparticles (UsAuNPs) in the size range of 4.0-7.0 nm was successfully immobilized on the surface of 2D metalloporphyrinic metal-organic framework nanosheets (2D MOF).

Development and performance evaluation of TaqMan real-time fluorescence quantitative methylation specific PCR for detecting methylation level of PER2.

Background: PER2 gene methylation is closely related to the occurrence and progress of some cancers, but there is no method to quantitatively detect PER2 methylation in conventional laboratories. So, we established a TaqMan real-time fluorescence quantitative methylation specific PCR (TaqMan real-time FQ-MSP) assay and use it for quantitative detection of PER2 methylation in leukemia patients.

Methods: According to the PER2 sequence searched by GenBank, a CpG sequence enrichment region of the PER2 gene promoter was selected, and the methylated and unmethylated target sequences were designed according to the law of bisulfite conversion of DNA to construct PER2 methylation positive and negative reference materials.

PER2: a potential molecular marker for hematological malignancies.

Circadian rhythm is a periodic change of organism according to the law of external environment, which is manifested in metabolism, cell proliferation, physiology and behavior. In recent years, the role of circadian genes in the occurrence and progression of hematological malignancies have been continuously demonstrated. PER2 is the core component of the circadian rhythm playing an important role in regulating the circadian rhythm of the biological clock.

Interference of Illusory Contour Perception by a Distractor.

The visual system is capable of recognizing objects when object information is widely separated in space, as revealed by the Kanizsa-type illusory contours (ICs). Attentional involvement in perception of ICs is an important topic, and the present study examined whether and how the processing of ICs is interfered with by a distractor. Discrimination between thin and short deformations of an illusory circle was investigated in the absence or presence of a central dynamic patch, with difficulty of discrimination varied in three levels (easy, medium, and hard).

Synthesis and X-Ray Crystal Structures of Trinuclear Nickel(II) Complexes Derived from Schiff Bases and Acetate Ligands with Biological Activity.

The reactions of Ni(OAc)2 2H2O with Schiff base ligands 5-bromo-2-((cyclopentylimino)methyl)phenol (HL1) and 5-bromo-2-(((2-(isopropylamino)ethyl)imino)methyl)phenol (HL2) in methanol afforded two discrete trinuclear com-plexes [Ni3(L1)2(?2-?1:?1-OAc)2(DMF)2(BrSal)2] (1) and [Ni3(L2)2(?2-?1:?1-OAc)2(?2-?2:?1-OAc)2] (2), where BrSal is the monoanionic form of 4-bromosalicylaldehyde. The complexes were characterized by elemental analysis, IR and UV-Vis spectroscopy. The crystal structures of the complexes have been determined by X-ray crystallography.

Wavelength-Flexible Thulium-Doped Fiber Laser Based on Digital Micromirror Array.

Wavelength-tunable thulium-doped fiber laser is demonstrated employing a digital micromirror device (DMD) in combination with a fixed grating. The diffraction property of four typical models of DMDs and its steering efficiency for the laser system are analyzed based on two-dimensional grating theory. By spatially modulating reflective patterns on a DMD, the stable, fast, and flexible tuning of lasing wavelength from 1930 nm to 2000 nm is achieved with wavelength tuning accuracy of 0.

High-dispersed FeO/Fe nanoparticles residing in 3D honeycomb-like N-doped graphitic carbon as high-performance room-temperature NO sensor.

This work illustrates a simple polymer thermal treatment strategy to develop high-dispersed FeO/Fe nanoparticles residing in honeycomb-like N-doped graphitic carbon (FeO/Fe@N-GC). The as-prepared FeO/Fe@N-GC composites consist of three-dimensional (3D) strutted interconnective graphitic carbon frame, which would not only refrain from restacking and facilitate the charge transfer, but also provide more reaction interface between gas molecules and materials. Benefiting from the synergistic merits of FeO/Fe, N-doping graphitic carbon, high surface area and unique 3D architectures, the optimal FeO/Fe@N-GC presents impressive sensitivity and selectivity for NO gas detection at room temperature with the response of 25.

Expressions of m6A RNA methylation regulators and their clinical predictive value in cervical squamous cell carcinoma and endometrial adenocarcinoma.

The mortality caused by cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) ranks second among female malignant tumour deaths, but their diagnostic and therapeutic targets are still limited. N6-methyladenosine (m6A) is the most common and extensive modification in mRNA molecules, and its methylation regulators participate in regulating the occurrence and development of many tumours. However, whether m6A RNA methylation regulators can be used as independent prognostic indicators of CESC remains unknown.

Controllable synthesis of MoS@MoO nanonetworks for enhanced NO room temperature sensing in air.

MoS2 nanosheets (NSs) are a promising gas sensing material at room temperature (RT) due to their unique properties and structures. Unfortunately, the activity of pure MoS2 NSs is highly affected by the adsorption of atmospheric oxygen, which strongly influences the stability of MoS2 sensing devices and significantly hinders the practical applications of these sensors in air. Heterostructure formation may be an effective approach to modulate the intrinsic electronic properties of MoS2 NSs.

Perceiving blurry scenes with translational optic flow, rotational optic flow or combined optic flow.

Perceiving the spatial layout of objects is crucial in visual scene perception. Optic flow provides information about spatial layout. This information is not affected by image blur because motion detection uses low spatial frequencies in image structure.

Interdomain I/O Optimization in Virtualized Sensor Networks.

In virtualized sensor networks, virtual machines (VMs) share the same hardware for sensing service consolidation and saving power. For those VMs that reside in the same hardware, frequent interdomain data transfers are invoked for data analytics, and sensor collaboration and actuation. Traditional ways of interdomain communications are based on virtual network interfaces of bilateral VMs for data sending and receiving.

One-step synthesis of palladium oxide-functionalized tin dioxide nanotubes: Characterization and high nitrogen dioxide gas sensing performance at room temperature.

Mesoporous palladium oxide (PdO)-functionalized tin dioxide (SnO) composite nanotubes (SPCTs) were prepared via one-step synthesis by electrospinning technology using ethanol and N,N-dimethylformamide (DMF) as solvents. Compared with pure SnO nanotubes, there were abundant mesopores and multiheterojunctions in PdO-functionalized SnO nanotubes. The sample with the molar ratio of SnO:PdO of 100:3 (3-SPCT) exhibited excellent response (∼20.