Publications by authors named "Hongyu Nian"
Peritoneal adhesion is a common complication of abdominal and pelvic surgery that can cause various clinical symptoms, including abdominal pain, intestinal obstruction, and female infertility, significantly impacting patient quality of life. Animal models of peritoneal adhesion are important tools for studying the mechanisms of adhesion formation and evaluating the effectiveness of prevention and treatment. Various methods for constructing animal models of peritoneal adhesion include physical injury, chemical injury, ischemia, infection, foreign body stimulation, and simulated surgery; however, none can fully simulate peritoneal adhesion in patients clinically.
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- Peritoneal adhesion (PA) arises from abnormal connections in the abdominal lining, often due to surgery or inflammation, leading to complications like pain, intestinal blockages, and infertility, impacting patients' quality of life.
- Macrophages play a crucial role in PA development, being able to switch between an inflammatory (M1) and a healing (M2) state based on their environment, which influences how adhesions form or resolve.
- This review focuses on understanding how macrophages and their different forms contribute to PA, with the aim of finding new prevention and treatment methods by managing these immune cells.
Background: In this study, we aimed to establish a stable and standardized animal model of peritoneal adhesions.
Methods: Forty-eight male Sprague-Dawley rats were randomly divided (n = 12 each) into blank control, classic cecum sidewall, ischemic button, and cecum-sidewall suture groups. The modified American Fertility Society adhesion score was used on postoperative day 7 to evaluate adhesions.