Prodigiosin inhibits proliferation and induces apoptosis through influencing amino acid metabolism in multiple myeloma.

The recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treatment for MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cell proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC range of MM cells.

The Effect of Acupuncture on the Morphology and Neural Coding Damage of the Central Amygdala in Mice with Chronic Inflammatory Pain and Depression.

Purpose: Observing the effects and roles of acupuncture on the morphology and neural coding damage of central amygdala (CeA) neurons in chronic inflammatory pain with depression (CIPD) mice and exploring the central nervous mechanism of acupuncture intervention in CIPD.

Methods: A CIPD model was established by injecting Complete Freund's Adjuvant (CFA) into the left hind foot. Using paw withdrawal latency (PWLs), forced swimming, and open field tests, 40 mice with successfully replicated models were selected and randomly divided into a model group, acupuncture group, and sham acupuncture group, with 12 mice in each group.

Continuous Transition between Bosonic Fractional Chern Insulator and Superfluid.

The properties of fractional Chern insulator (FCI) phases and the phase transitions between FCIs and Mott insulators in bosonic systems are well studied. The continuous transitions between FCI and superfluids (SFs), however, despite the inspiring field theoretical predictions [M. Barkeshli and J.

Concurrent Tumor-Treating Fields and Chemoradiotherapy: Outcomes in Grade 4 Glioma Patients.

Background: Surgical intervention, complemented by radiotherapy and chemotherapy with temozolomide, constitutes the conventional treatment protocol for patients with newly diagnosed grade 4 glioma. We have conducted a research to evaluate the efficacy and safety of an integrated treatment regimen that incorporates tumor-treating fields with concurrent chemoradiotherapy.

Methods: This retrospective research analyzed the clinical data of 39 adults who were newly diagnosed with World Health Organization (WHO) grade 4 gliomas at the First Affiliated Hospital of Nanjing Medical University, between February 2022 and April 2023.

Voluntary environmental programs and corporate labor income share: Evidence from ISO14001 environmental standard certification.

As a key tool for addressing environmental pollution and fostering a green economy, voluntary environmental regulation has a profound impact on the distribution of factor income. To increase labor income share and alleviate conflicts between labor and capital, this study offers new theoretical insights and solutions from the perspective of voluntary environmental programs. Specifically, it treats ISO14001 environmental standard certification as a quasi-natural experiment to examine the causal relationship between voluntary environmental programs and corporate labor income share and derives the following conclusions.

Association between the triglyceride-glucose index and mortality in the asthma population.

Objective: To explore the relationship between the triglyceride-glucose (TyG) index and mortality in individuals with asthma, given the inconclusive evidence linking metabolic dysfunction to asthma outcomes.

Research Design And Methods: We analyzed data from 5985 adults with asthma from the National Health and Nutrition Examination Survey (NHANES) 2001-2018. We used multivariable weighted Cox regression, smoothing curve fitting, survival curve analysis, and subgroup analysis to assess the correlation between the TyG index and survival rates.

Environmentally Friendly and Simple Recycling of Titanium Alloy Scrap via Deoxygenation with Hybrid Hydrogen Plasma Arc.

The potential of hydrogen plasma arc technology for the efficient deoxygenation and recycling of titanium alloy scrap is explored. The results of thermodynamic analysis reveal that hydrogen plasma is suitable for oxygen removal. The intermediate stages of the deoxygenation process are sequentially analyzed, showing that the hydrogen plasma arc primarily facilitated the reduction and dissolution of oxides as well as eliminated interstitial oxygen.

Non-immunoglobin scaffold binders as efficient affinity ligands for purification of broad-spectrum serum albumins.

Although non-immunoglobin scaffold binders with high affinity and broad spectrum for albumin are attractive for lab-scale albumin purification, affinity chromatography based on these binders has not been developed. Here, the albumin-binding capabilities of representative binders, including protein G-derived albumin binding domain (ABD), albumin binding nanofitins (ABNF), and human serum albumin affimer 31 (HSA31) were predicted by interaction structure analysis and verified by experimental assays. Interaction structure prediction suggested that ABD possessed great potential to bind human (HSA), rhesus monkey (RhSA), mouse (MSA), and rat serum albumin (RSA), whereas ABNF might only bind HSA and bovine serum albumin (BSA), and HSA31 might not bind any of the tested albumins.

How Rice Responds to Temperature Changes and Defeats Heat Stress.

With the intensification of the greenhouse effect, a series of natural phenomena, such as global warming, are gradually recognized; when the ambient temperature increases to the extent that it causes heat stress in plants, agricultural production will inevitably be affected. Therefore, several issues associated with heat stress in crops urgently need to be solved. Rice is one of the momentous food crops for humans, widely planted in tropical and subtropical monsoon regions.

Capture of RNA-binding proteins across mouse tissues using HARD-AP.

RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism, but a comprehensive picture of RBP expression across tissues is lacking. Here, we describe our development of the method we call HARD-AP that robustly retrieves RBPs and tightly associated RNA regulatory complexes from cultured cells and fresh tissues. We successfully use HARD-AP to establish a comprehensive atlas of RBPs across mouse primary organs.

From fractional quantum anomalous Hall smectics to polar smectic metals: nontrivial interplay between electronic liquid crystal order and topological order in correlated topological flat bands.

Symmetry-breaking orders can not only compete with each other, but also be intertwined, and the intertwined topological and symmetry-breaking orders make the situation more intriguing. This work examines the archetypal correlated flat band model on a checkerboard lattice at fillingν=2/3and we find that the unique interplay between smectic charge order and topological order gives rise to two novel quantum states. As the interaction strength increases, the system first transitions from a Fermi liquid (FL) into FQAH smectic (FQAHS) state, where the topological order coexists cooperatively with smectic charge order with enlarged ground-state degeneracy and interestingly, the Hall conductivity isσxy=ν=2/3, different from the band-folding or doping scenarios.

Regulation of Electron Delocalization Region in 2D Heteroligand-Based Copper-Organic Framework to Enhance Charge Storage.

The rechargeable aqueous ammonium ion battery shows great potential in low-cost energy storage system because of its long life and environmental friendliness. However, most inorganic host materials used in ammonium ion batteries are still limited by slow diffusion kinetics. Herein, it is identified that a 2D heteroligand-based copper-organic framework featuring numerous ammonium ion adsorption site in the π-conjugated periodic skeleton supplies multiple accessible redox-active sites for high-performance ammonium storage.

Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Coronary Artery Disease Patients with Different Glucose Metabolism Status.

Background: Abnormal glucose metabolism is present in most patients with coronary artery disease (CAD). Inflammation is considered to be a common risk factor for CAD and diabetes. Fibrinogen-to-albumin ratio (FAR), a novel inflammation biomarker, has been proposed as a predictor for cardiovascular disease.

Tailings particle size effects on pollution and ecological remediation: A case study of an iron tailings reservoir.

The particle size distribution in tailings notably influences their physical properties and behavior. Despite this, our understanding of how the distribution of tailings particle sizes impacts in situ pollution and ecological remediation in in-situ environment remains limited. In this study, an iron tailings reservoir was sampled along a particle flow path to compare the pollution characteristic and microbial communities across regions with different particle sizes.

Thermodynamic Response and Neutral Excitations in Integer and Fractional Quantum Anomalous Hall States Emerging from Correlated Flat Bands.

Integer and fractional Chern insulators have been extensively explored in correlated flat band models. Recently, the prediction and experimental observation of fractional quantum anomalous Hall (FQAH) states with spontaneous time-reversal symmetry breaking have garnered attention. While the thermodynamics of integer quantum anomalous Hall (IQAH) states have been systematically studied, our theoretical knowledge on thermodynamic properties of FQAH states has been severely limited.

Impacts of pilot carbon emission trading policies on urban environmental pollution: Evidence from China.

The trading of carbon emissions is a crucial regulatory method to address environmental pollution issues. This study takes China's carbon emission trading pilot policy established in 2013 as a quasi-natural experiment and uses the DID model to empirically test the urban panel data from 2006 to 2019. The results show that the carbon emission trading pilot policy can effectively reduce urban environmental pollution, and this effect is more noticeable in mid-western cities, northern cities, cities with fewer resources, and large-scale cities.

Novel Synergistic Probiotic Intervention: Transcriptomic and Metabolomic Analysis Reveals Ameliorative Effects on Immunity, Gut Barrier, and Metabolism of Mice during Infection.

( a prevalent cause of foodborne infection, induces significant changes in the host transcriptome and metabolome. The lack of therapeutics with minimal or no side effects prompts the scientific community to explore alternative therapies. This study investigates the therapeutic potential of a probiotic mixture comprising () and () against , utilizing transcriptome and metabolomic analyses, a novel approach that has not been previously documented.

Deciphering Microbiome, Transcriptome, and Metabolic Interactions in the Presence of Probiotic against Typhimurium in a Murine Model.

Typhimurium (. Typhimurium), a foodborne pathogen that poses significant public health risks to humans and animals, presents a formidable challenge due to its antibiotic resistance. This study explores the potential of ( 1.

Advances in applications of artificial intelligence algorithms for cancer-related miRNA research.

MiRNAs are a class of small non-coding RNAs, which regulate gene expression post-transcriptionally by partial complementary base pairing. Aberrant miRNA expressions have been reported in tumor tissues and peripheral blood of cancer patients. In recent years, artificial intelligence algorithms such as machine learning and deep learning have been widely used in bioinformatic research.

The white matter characteristic of the genu of corpus callosum coupled with pain intensity and negative emotion scores in patients with trigeminal neuralgia: a multivariate analysis.

Background: Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder that not only causes intense pain but also affects the psychological health of patients. Since TN pain intensity and negative emotion may be grounded in our own pain experiences, they exhibit huge inter-individual differences. This study investigates the effect of inter-individual differences in pain intensity and negative emotion on brain structure in patients with TN and the possible pathophysiology mechanism underlying this disease.