Synthesis and Characterization of Ultralight Syndiotactic Polystyrene Aerogels Prepared by Freeze-Drying.

We have developed a strategy to synthesize high-quality ultralight (<10 mg/cm) syndiotactic polystyrene (sPS) aerogels. The ultralight sPS aerogels with the same shape as gels were prepared via direct freeze-drying of -xylene-based sPS gels without cumbersome solvent exchange steps. Due to the high melting point of -xylene (13 °C), it can be solidified during the freeze-drying process, and no solvent exchanges were required to suppress the collapse during the formation of sPS aerogels, unlike in typical sPS aerogel preparation.

Role of oxidative balance score in staging and mortality risk of cardiovascular-kidney-metabolic syndrome: Insights from traditional and machine learning approaches.

Objectives: To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk of cardiovascular-kidney-metabolic syndrome (CKM).

Methods: Data of this study were from the National Health and Nutrition Examination Survey 1999-2018. We performed cross-sectional analyses using multinomial logistic regression to investigate the relationship between OBS and CKM staging.

Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks.

Metal-phenolic networks (MPNs), which comprise supramolecular amorphous networks formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis of the cumulative research advancements and utilizations of MPNs in nanomedicine remains absent. Thus, this review endeavors to firstly delineate the characteristic polyphenols, metal ions, and their intricate interaction modalities within MPNs.

ELF5 gene promotes milk lipid synthesis in goat mammary epithelial cells by transcriptomic analysis.

E74-like factor 5 (ELF5) is an Ets transcription factor of epithelial development, while the function of ELF5 gene in goat milk fat synthesis remains to be elucidated. In goat mammary epithelial cells, we performed RNA sequencing and analyzed differentially expressed genes (DEGs) after ELF5 gene overexpression. ELF5 gene significantly up-regulated the synthesis of triglyceride, total cholesterol, free fatty acid, and lipid droplets.

Tannin alleviated reproductive dysfunction in pregnant ewes infected with .

Introduction: () infection has a significant impact on the health of pregnant ewes and adversely affects fetal development, highlighting the critical need for a non-toxic feed additive as an alternative and sustainable control strategy. Tannin is a kind of polyphenol compound, which has certain antiparasitic. The objective of this study was to evaluate the impact of dietary tannin supplementation on fecal egg count (FEC), packed cell volume (PCV), complete blood count (CBC), hormone levels, inflammatory markers, placental inflammation, and fetal growth and development in pregnant ewes infected with .

[Construction and Validation of A Prognostic Model for Lung Adenocarcinoma Based on Ferroptosis-related Genes].

Background: Ferroptosis-related genes play a crucial role in regulating intracellular iron homeostasis and lipid peroxidation, and they are involved in the regulation of tumor growth and drug resistance. The expression of ferroptosis-related genes in tumor tissues can be used to predict patients' future survival times, aiding doctors and patients in anticipating disease progression. Based on the sequencing data of lung adenocarcinoma (LUAD) patients from The Cancer Genome Atlas (TCGA) database, this study identified genes involved in the regulation of ferroptosis, constructed a prognostic model, and evaluated the predictive performance of the model.

Study on the mechanism of Huangqi Chifeng decoction regulating ferroptosis inhibiting smooth muscle cells derived foam cell formation.

Ethnopharmacological Relevance: Chinese medicine, specifically Huangqi Chifeng Decoction (HQCF), is recognized for its efficacy in treating atherosclerosis (AS), a common cardiovascular disease. Despite its established benefits in addressing Qi deficiency, blood stasis, and collateral obstruction, the precise mechanism through which HQCF affects AS remains unclear.

Aim Of The Study: This study investigated the potential of HQCF to mitigate AS by suppressing smooth muscle cell (SMC) foam formation through the ferroptosis pathway.

Retrospect and prospect: reproductive technologies in beef cattle.

The cattle industry is critical for agriculture's development, and reproductive technology has revolutionized its development over the past century. The core task of developing the beef cattle industry is to increase quantity and improve quality, which cannot be separated from the key link of reproduction. It involves artificial insemination (AI), semen collection and freezing, multiple ovulation embryo transfer (MOET), and genome editing.

Ceria Nanoparticles Improve the Quality of Aging Oocytes in Mice by Enhancing ROS Scavenging Ability.

If fertilization does not occur in a timely manner after ovulation, then that can lead to aging and a decline in relation to oocyte quality, which have detrimental effects on subsequent embryo development and offspring. Reactive oxygen species (ROS) induced oxidative stress is the main factor in the deterioration of oocyte aging. Herein, ceria nanoparticles (NPs) have been developed as ROS scavengers to improve the quality of aging oocytes.

Red-crowned Cranes (Grus japonensis) habitat changes in China from 1980 to 2020: Spatio-temporal distribution.

The Red-crowned Crane (Grus japonensis) is a species unique to Asia, with a global population of about 3430. It was a Class I protected wild animal in China and was listed as vulnerable on the World Conservation Union (IUCN) Red List. The Red-crowned Crane was at the top of the food chain of wetland ecosystems and was one of the flagship species for wetland biodiversity conservation.

Restoring Vascular Smooth Muscle Cell Mitochondrial Function Attenuates Abdominal Aortic Aneurysm in Mice.

Background: Abdominal aortic aneurysm (AAA) is a complex vascular pathology without pharmaceutical interventions. This study aimed to evaluate whether restoring vascular smooth muscle cell (VSMC) mitochondrial function could prevent AAA development.

Methods: Ang II (angiotensin II)-induced AAA was established in -deficient mice, and the gene expression profiles in abdominal aortic tissues exhibiting varying degrees of severity were analyzed.

[Antidepressant mechanism of Baihe Dihuang Decoction based on metabolomics and network pharmacology].

The Baihe Dihuang Decoction(BDD) is a representative traditional Chinese medicine formula that has been used to treat depression. This study employed metabolomics and network pharmacology to investigate the mechanism of BDD in the treatment of depression. Fifty male Sprague-Dawley(SD) rats were randomly assigned to the normal control group, model group, fluoxetine group, and high-and low-dose BDD groups.

Microneedle-based nanodrugs for tumor immunotherapy.

Microneedles have emerged as a promising and effective method for delivering therapeutic drugs and immunobiologics to treat various diseases. It is widely recognized that immune therapy has limited efficacy in solid tumors due to physical barriers and the immunosuppressive tumor microenvironment. Microneedle-based nanodrugs (NDMNs) offer a novel approach to overcome these limitations.

Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.

Cancer stem cells (CSCs) are key drivers of cancer progression and therapeutic resistance. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of CSC properties. The aim of this study was to investigate the role of MIR4435-2HG in regulating CSC characteristics, tumorigenesis, and chemoresistance in pancreatic cancer.

Topological Distribution of KCNH2 Variants and Genotype-Phenotype Relationship in Patients With Long QT Syndrome.

Aims: The aim of this study was to investigate the topological distribution of single nucleotide variants (SNVs) in the KCNH2 gene from patients with type 2 long QT syndrome (LQT2) and to explore the genotype-phenotype relationships.

Methods: Information on KCNH2 variants in LQT2 patients was retrospectively obtained from the HGMD, ClinVar, and PubMed databases through October 2022. Pathogenicity of SNV was classified according to the American College of Medical Genetics and Genomics (ACMG) guidelines.

Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5.

Background: Precisely predicting lymph node metastasis (LNM) status is critical for the treatment of early non-small5-cell lung cancer (NSCLC). In this study, we developed a LNM prediction tool for peripheral NSCLC with a tumor diameter ≤ 2.0 cm and consolidation-to-tumor ratio (CTR) > 0.

Pulse Current-Induced Homogeneous Phase Nucleation for High-Performance Conversion-Type Cathodes.

Conversion-type transition metal-based materials (MZ) are considered promising cathodes for lithium metal batteries due to their low cost, abundant availability, and high theoretical energy density. However, they suffer from rapid capacity decay caused by the transformation into two inhomogeneous phases during discharge. Herein, we use a pulse current discharge activation method (under 3C) to induce homogeneous phase nucleations.

Environmentally Friendly Water-Based Carbon Slurry with Carboxylated Carbon Nanosheets for Optimizing the Electrode-Collector Interface in Lithium-Ion Batteries.

Coating a carbon layer on the surface of the current collector can enhance the performance of lithium-ion batteries by improving the interfacial conductivity and the adhesion of the active material. However, traditional carbon-coated copper foil uses hydrophobic graphite as the conductive material, which has poor dispersion and adhesion to the binder, and the preparation process requires the use of environmentally harmful organic solvents. In this work, carboxylated carbon nanosheets (CCN) are synthesized via a simplified ball-milling method utilizing graphite and dry ice as starting materials, and a water-based carbon slurry is formulated, employing environmentally friendly deionized water as the solvent.

Foundation Models for Translational Cancer Biology.

Cancer remains a leading cause of death globally. The complexity and diversity of cancer-related datasets across different specialties pose challenges in refining precision medicine for oncology. Foundation models offer a promising solution.

Generation of tunable high-order vortex beams from a Hermite-Gaussian thin-disk laser.

We demonstrate the generation of high-order, high-power vortex modes from a Hermite-Gaussian (HG) Yb:YAG thin-disk oscillator, with tunable mode orders ranging continuously from one to ten. To the best of our knowledge, this is the highest order of HG and vortex modes obtained using a thin-disk module. The output power for most of these modes reaches up to 10 W, setting a new benchmark for intracavity high-order HG mode generation.

Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine.

Background: Compound schizonepeta fumigation lotion is a type of Chinese patent medicine for external use. It has the effect of dispelling wind, eliminating dampness, reducing swelling, and relieving pain. Clinically, it is used for anal fumigation and treatment of external hemorrhoids, anal fissures, and other diseases.

Multi-omics perspective: mechanisms of gastrointestinal injury repair.

In this review, we examine the significance of multi-omics technologies in understanding the plethora of intricate processes that activate gastrointestinal (GI) injury repair. Multi-omics, which includes genomics, transcriptomics, proteomics, and metabolomics, allows intricate mapping of cellular responses and molecular pathways involved in GI repair. We highlight the potential of multi-omics to discover previously unknown therapeutic targets or elucidate the molecular basis of the pathogenesis of GI.

Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice.

Background: Xueshuantong injection (Lyophilized) (XSTI) is widely used to treat cardiovascular and cerebrovascular diseases. However, anaphylactoid reactions (ARs) are frequently reported as one of its side effects, and the mechanisms of ARs and their relationship with the different immune status are still not well understood.

Purpose: This article aims to examine the sensitizing effect of XSTI, explore the impact of normal and immunocompromised states on ARs, and analyze AR-related metabolic pathways by metabolomics.