Evaluating the therapeutic efficacy of ozone liquid dressing in healing wounds associated with bullous pemphigoid.

Bullous pemphigoid (BP) is a chronic autoimmune condition characterized by painful blistering wounds. While effective, conventional treatments often have significant side effects. This study evaluates the therapeutic efficacy of Ozone Liquid Dressing (OLD), an innovative adjunct treatment, in enhancing wound healing, reducing infection rates, and alleviating pain associated with BP.

Frequency-locked Wireless Multifunctional Surface Acoustic Wave Sensors.

Surface acoustic waves (SAWs) have shown great potential for developing sensors for structural health monitoring (SHM) and lab-on-a-chip (LOC) applications. Existing SAW sensors mainly rely on measuring the frequency shifts of high-frequency (., >0.

Case report: Dupilumab-induced linear psoriasis: a rare presentation.

A 42 year-old male with prurigo nodularis treated with dupilumab showed a case of linear psoriasis, highlighting the potential of dupilumab to induce immune shift and chimeric gene expression.

Paradoxical Behçet's Disease after Ixekizumab: A Case Report and Literature Review.

Behçet's disease is a chronic inflammatory condition that affects multiple organs and systems. It is characterized by recurrent oral and genital ulcers. A previous study reported that the IL-17A inhibitor secukinumab can improve the skin and mucosal manifestations in patients with refractory Behçet's disease.

Putting Charge Transfer Degree as a Bridge Connecting Surface-Enhanced Raman Spectroscopy and Photocatalysis.

To date, few systematic approach has been established for predicting catalytic performance by analyzing the spectral information of molecules adsorbed on photocatalyst surfaces. Effective charge transfer (CT) between the semiconductor photocatalysts and surface-absorbed molecules is essential for enhancing catalytic activity and optimizing light energy utilization. This study aimed to validate the surface-enhanced Raman spectroscopy (SERS) based on the CT enhancement mechanism in investigating the CT process during semiconductor photocatalytic C-C coupling model reactions.

Competencies of nurses to participate in safe medication management practices for biologics: A scoping review.

Aim: To review the existing literature relating to nurse competence in safe medication management practices for biologics, identify evidence, and develop a competency framework to clarify the role of nurses in these practices.

Background: With the widespread use of biological agents in disease treatment, ensuring the safe and economical use of high-cost medicines is particularly important. Even though nurses are essential in patient care, detailed knowledge regarding their competence and role in the safe administration of biologics is lacking.

CGG Repeat Expansion in Causing Overlapping Oculopharyngodistal Myopathy and Neuronal Intranuclear Inclusion Disease With Diffusion Weighted Imaging Abnormality in the Cerebellum.

Background And Purpose: CGG repeat expansion in the 5' untranslated region (5'UTR) of the Notch 2 N-terminal-like C gene () has been associated with neuronal intranuclear inclusion disease (NIID) and oculopharyngodistal myopathy type 3 (OPDM3). Few OPDM3 patients have been reported. This report describes two OPDM3 patients with novel imaging findings who presented the typical features of NIID, and reviews all OPDM3 cases available in the literature.

Discovery of 4-(isopentyloxy)-3-nitrobenzamide derivatives as xanthine oxidase inhibitors through a non-anthraquinone exploration.

In our previous study, we reported a series of N-(9,10-anthraquinone-2-carbonyl) amino acid derivatives as novel inhibitors of xanthine oxidase (XO). Recognizing the suboptimal drug-like properties associated with the anthraquinone moiety, we embarked on a nonanthraquinone medicinal chemistry exploration in the current investigation. Through systematic structure-activity relationship (SAR) studies, we identified a series of 4-(isopentyloxy)-3-nitrobenzamide derivatives exhibiting excellent in vitro potency against XO.

Investigation of Viscoelastic Guided Wave Properties in Anisotropic Laminated Composites Using a Legendre Orthogonal Polynomials Expansion-Assisted Viscoelastodynamic Model.

This study investigates viscoelastic guided wave properties (e.g., complex-wavenumber-, phase-velocity-, and attenuation-frequency relations) for multiple modes, including different orders of antisymmetric, symmetric, and shear horizontal modes in viscoelastic anisotropic laminated composites.

Paradoxical reaction to IL-17A inhibitor: a case report and literature review.

Objective: A case of pustular psoriasis after treatment with secukinumab in a patient with plaque psoriasis is reported, which is the first case in China. To summarize the clinical characteristics of patients who developed the rare paradoxical reaction and treatment options received IL-17A antagonist therapy, we conducted a further literature review.

Methods: Data were analyzed from a patient with plaque psoriasis who developed pustular psoriasis after treatment with secukinumab.

Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients.

Lupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and immunopathogenesis.

Case report: A novel PTCH1 frameshift mutation leading to nevoid basal cell carcinoma syndrome.

A patient presenting with several basal cell carcinomas, pigmented nevi, and developmental defects was diagnosed with nevoid basal cell carcinoma syndrome. Gene panel sequencing and Sanger sequencing were used to identify a novel heterozygous frameshift mutation, c.1312dupA:p.

Potential immune evasion of the severe acute respiratory syndrome coronavirus 2 Omicron variants.

Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic. The Omicron variant (B.1.

Cyclophosphamide reduces gene transcriptional activity and embryo in vitro development by inhibiting NF-κB expression through decreasing AcH4K12.

Cyclophosphamide (CTX), a widely used chemotherapeutic agent for cancer treatment, has been associated with long-term toxicity and detrimental effects on oocytes and ovaries, resulting in female reproductive dysfunction. This study aimed to investigate the potential impact of CTX on in vitro maturation (IVM) injury of porcine oocytes and subsequent embryonic development, as well as its effects on epigenetic modification and gene activation during early embryonic development. The results demonstrated that CTX treatment caused aberrant spindle structure and mitochondrial dysfunction during oocyte maturation, inducing DNA damage and early apoptosis, which consequently disrupted meiotic maturation.

Study of charge transfer contribution in Surface-Enhanced Raman scattering (SERS) based on indium oxide nanoparticle substrates.

Surface-enhanced Raman scattering (SERS) has outstanding merits in biochemical molecular analysis, and the development of new SERS substrates is the focus of research. Herein, InO nanoparticles (NPs) were synthesized by a high temperature pyrolysis method with cubic phase and small particle size at 10 nm. The structures and properties of InO NPs were characterized by X-ray powder diffraction (XRD), transmission electron microscope (TEM) and other characterization methods.

Case report: Post-streptococcal pustulosis after subcutaneous injection of secukinumab.

An acute diffuse pustular eruption occurred in a patient after secukinumab injection and then the clinical presentation has been related to streptococcus infection after it has been isolated from throat swabs. Pustulosisacuta generalisata was definitively diagnosed. Antibiotic treatment had a poor effect, but the response to glucocorticoids was better.

Ginsenoside Rg1 activates brown adipose tissue to counteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition.

Obesity is a global health problem strongly linked to gut microbes and their metabolites. In this study, ginsenoside Rg1 (Rg1) reduced lipid droplet size and hepatic lipid accumulation by activating uncoupling protein 1 expression in brown adipose tissue (BAT), which in turn inhibited high-fat diet (HFD)-induced weight gain in mice. Furthermore, the intestinal flora of mice was altered, the abundance of , , , and was upregulated, and the concentrations of fecal bile acids were altered, with cholic acid and taurocholic acid concentrations being significantly increased.

Inverse of initial stress in carbon fiber reinforced polymer laminates using lamb waves and deep neural network.

The prediction of the initial stress in composites is essential for the non-destructive testing (NDT) and structural health monitoring (SHM) of carbon fibre reinforced polymer (CFRP). This paper examines the potential of Lamb waves in the inverse of initial stress by calculating the influence of initial stress on the dispersion characteristics of Lamb waves propagating in multilayered CFRP laminates. By introducing the mechanics of incremental deformation into the linear three-dimensional elasticity theory, the Legendre orthogonal polynomial expansion (LOPE) method is used to mathematically model the Lamb wave propagating in multilayered CFRP laminates subjected to horizontal and vertical homogeneous initial stresses.

Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis.

The host genome may influence the composition of the intestinal microbiota, and the intestinal microbiota has a significant effect on muscle growth and development. In this study, we found that the deletion of the myostatin () gene positively regulates the expression of the intestinal tight junction-related genes and through the myosin light-chain kinase/myosin light chain pathway. The intestinal structure of pigs differed from wild-type, including by the presence of a thicker muscularis and longer plicae.

Evaluation of Plastic Deformation Considering the Phase-Mismatching Phenomenon of Nonlinear Lamb Wave Mixing.

Nonlinear guided elastic waves have attracted extensive attention owing to their high sensitivity to microstructural changes. However, based on the widely used second harmonics, third harmonics and static components, it is still difficult to locate the micro-defects. Perhaps the nonlinear mixing of guided waves can solve these problems since their modes, frequencies and propagation direction can be flexibly selected.

The ginsenoside Rh2 protects porcine oocytes against aging and oxidative stress by regulating SIRT1 expression and mitochondrial activity.

Post-ovulatory aging, a major problem faced by oocytes cultured in vitro, causes oxidative damage and mitochondrial dysfunction in oocytes. The ginsenoside Rh2 is one of the main monomeric components of ginseng, but its effects on porcine oocytes are unknown. In the present study, in vitro aging (IVA) and accelerated induction of aging using HO resulted in DNA damage and an increased incidence of abnormal spindle formation in porcine oocytes.