Understanding the Molecular Mechanisms of Pyrene in Governing the Critical Metabolic Circuits of .

Pyrene, a representative polycyclic aromatic hydrocarbon, frequently occurs in aquatic environments and is associated with lethal impacts on humans and wildlife. This study examined the impact of pyrene on , a dinoflagellate responsible for harmful algal blooms, and their capability to bioremove pyrene. In a 96 h exposure experiment, effectively reduced the pyrene concentration in seawater to 50, 100, and 200 μg/L, with a combined removal efficiency of 96% in seawater.

Oral Immunization of Mice with a Nonantibiotic Recombinant Coexpressing TsNd and gp43 Protein Vaccine Combined with a Murine Interleukin-33 Adjuvant.

Trichinellosis, a zoonotic disease transmitted through food and caused by , is a significant health concern worldwide. Therefore, developing a safe and effective vaccine to combat infection is essential. In this study, a nonantibiotic strain lacking the gene served as a live bacterial vector to deliver antigens to the host, creating a novel oral vaccine.

Mechanistic impact of Gracilaria bailinae extracts on photosynthesis and metabolism in Phaeodactylum tricornutum.

In the intricate realm of aquatic ecosystems, biotic interactions play pivotal roles in shaping the physiological responses and survival strategies of microorganisms. This study investigates the effects of Gracilaria bailinae on photosynthesis and metabolism on the diatom Phaeodactylum tricornutum and the ecological significance. Our results reveal considerable suppression by G.

Microplastics-exposure experience aggravates the accumulation of diarrhetic shellfish toxins (DSTs) in thick-shell mussel Mytilus coruscus through impairing detoxification processes.

Possessing sessile filter-feeding lifestyle, bivalves are more susceptible to contamination by benthic phycotoxins such as the diarrhetic shellfish toxins (DSTs). Due to the prevalence of microplastics (MPs) in aquatic environments, bivalve that experienced MP-exposure are potentially at higher risk from exposure to DSTs-producing microalgae, however, little is known about the impacts of past MP-exposure experience on the accumulation of DSTs. In this study, taking polystyrene (PS) MPs and DSTs-producing Prorocentrum lima as representatives, the impacts of MP-exposure on DSTs accumulation were evaluated in the thick-shell mussel Mytilus coruscus.

Enhanced biodegradation of glyphosate by Chlorella sorokiniana engineered with exogenous purple acid phosphatase.

Organophosphate pesticides, particularly glyphosate, persist in aquatic environments due to widespread agricultural usage, posing substantial environmental and health risks. This study explores the bioremediation potential of genetically engineered Chlorella sorokiniana, expressing purple acid phosphatase (PAP) from Phaeodactylum tricornutum, for glyphosate biodegradation. The engineered strain (OE line) demonstrated complete glyphosate biodegradation at concentrations below 10 ppm within 4-6 days, surpassing the wild type (WT).

Wormlike Micellar Glycerol Solutions Formed from a Double-Tailed Surfactant with Two Quaternary Ammonium Head Groups.

Herein, a quaternary ammonium surfactant with dual heads and tails, ,,,,-pentamethyl--(3-(2-tetradecylhexadecanamido)propyl)propane-1,3-diaminium dibromide, abbreviated as Di-C14-N2, was synthesized. For the first time, clear observation of aggregate structures formed by surfactants in pure glycerol systems was achieved using cryogenic transmission electron microscopy (cryo-TEM). The system's rheological properties were analyzed using both steady-state shear and oscillatory rheological measurements.

Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis.

Caspase-1 plays a central role in innate immunity, as its activation by inflammasomes induces the production of proinflammatory cytokines and pyroptosis. However, specific inhibition of the enzymatic activity of this protease is not effective in suppressing inflammation, owing to its enzyme-independent function. Herein, we identified a cyclohexenyl isothiocyanate compound () that potently inhibited caspase-1 activity and suppressed the assembly and activation of the NLRP3 inflammasome and gasdermin-D-mediated pyroptosis.

Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.

Purpose: Tanshinone IIA (Tan-IIA) is widely used in patients with diabetic nephropathy (DN), but its protective effect on podocytes in DN has not been well studied. In this study, the effects of Tan-IIA on autophagy and inflammation of glomerular podocytes in DN were observed in vivo and in vitro, and the underlying mechanisms were investigated. Irbesartan, an angiotensin II receptor blocker, is a representative medication for the clinical treatment of DN.

Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity.

The tumor microenvironment (TME) has a significant impact on tumor growth and immunotherapy efficacies. However, the precise cellular interactions and spatial organizations within the TME that drive these effects remain elusive. Using advanced multiplex imaging techniques, we have discovered that regulatory T cells (Tregs) accumulate around lymphatic vessels in the peripheral tumor stroma.

Edible hydrogel with dual network structure for weight management.

Obesity, a global health crisis, is fueled by shifts in behavior and environmental factors, notably increased consumption of energy-dense processed foods and inadequate dietary fiber. Traditional weight loss methods pose safety challenges. Sodium carboxymethylcellulose (CMC), a promising dietary fiber supplement, aids weight management.

Synergistic and stepwise treatment of resveratrol and catechol in Haematococcus pluvialis for the overproduction of biomass and astaxanthin.

To increase the production of biomass and astaxanthin from Haematococcus pluvialis to meet the high market demand for astaxanthin, this study recruited two typical and negligible phytohormones (namely resveratrol and catechol) for the stepwise treatments of H. pluvialis. It was found that the hybrid and sequential treatments of resveratrol (200 μmol) and catechol (100 μmol) had achieved the maximum astaxanthin content at 33.

Physiological and genetic responses of the benthic dinoflagellate Prorocentrum lima to polystyrene microplastics.

Microplastics are well known as contaminants in marine environments. With the development of biofilms, most microplastics will eventually sink and deposit in benthic environment. However, little research has been done on benthic toxic dinoflagellates, and the effects of microplastics on benthic dinoflagellates are unknown.

Ag-modified enhance the performances of ZnO@CFs based omnidirectional photoelectrochemical ultraviolet detectors.

There are several prospective applications for omnidirectional ultraviolet (UV) detectors and underwater detection detectors in optical systems and optical fields. In this work, ZnO nanorods arrays were grown on carbon fibers (CFs). An appropriate amount of Ag nanoparticles (NPs) was deposited on the surface of ZnO nanorods by photochemical deposition.

Knowledge, attitudes, and practices among Chinese reproductive-age women toward uterine adenomyosis.

Objective: This study aimed to assess the knowledge, attitudes and practices (KAP) among Chinese reproductive-age women toward uterine adenomyosis.

Methods: This web-based cross-sectional study was conducted between April 2023 and September 2023 at the Second Hospital of Hebei Medical University. A self-designed questionnaire was developed to collect demographic information of reproductive-age women, and assess their KAP toward uterine adenomyosis.

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis.

Insufficient initial vascularization plays a pivotal role in the ineffectiveness of bone biomaterials for treating bone defects. Consequently, enhancing the angiogenic properties of bone repair biomaterials holds immense importance in augmenting the efficacy of bone regeneration. In this context, we have successfully engineered a composite hydrogel capable of promoting vascularization in the process of bone regeneration.

-Toluenesulfonic Acid Modified Two-Dimensional ZrSe as a Hole Transport Layer for High-Performance Organic Solar Cells.

Two-dimensional (2D) materials have attracted attention due to their excellent optoelectronic properties, but their applications are limited by their defects and vacancies. Surface modification is an effective method to restore their performance. Here, ZrSe is modified with conductive polymer -toluenesulfonic acid (PTSA).