Publications by authors named "Hongye Chang"
Article Synopsis
- A network meta-analysis was conducted to compare the effectiveness of recent Alzheimer's disease drugs based on data from randomized controlled trials published between 2020 and 2024.
- The analysis found GV-971 and Lecanemab to be particularly effective in improving specific cognitive assessments, with Donanemab showing promise for slowing functional decline.
- Overall, GV-971 was identified as the top drug for cognitive improvement, while Donanemab and Lecanemab demonstrated significant efficacy in other areas of Alzheimer's treatment.
Diabetes-associated cognitive dysfunction (DACD) is a complication of diabetes mellitus that leads to an increased risk of cognitive impairment and dementia. However, the molecular mechanism underlying DACD has not been elucidated, and a promising therapy for this disease remains to be established. Hydrogen sulfide (HS), a significant antioxidative and anti-inflammatory gasotransmitter, has emerged as a neuroprotective agent.
View Article and Find Full Text PDFAims/introduction: Micro-ribonucleic acids (miRNAs) possess crucial functions in governing metabolisms associated with type 2 diabetes mellitus. This study aimed to investigate the role of miR-23a-3p in pyroptosis caused by nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 (NLRP3) inflammatory body activation, thereby reducing the occurrence of type 2 diabetes mellitus.
Materials And Methods: miR-23a-3p and NIMA-related kinase 7 (NEK7) expression in type 2 diabetes mellitus patients and rat models was examined.