Identification of osmotic stress resistance mediated by in apple.

KAR (Karrikin), a novel plant growth regulator, can be recognized specifically by plants and can activate resistance responses. MdKAI2 is the natural receptor of KARs in apple. Here, we report the identification of osmotic stress resistance in via the method of genetic transformation.

Preparation of a chitosan/polyvinyl alcohol-based dual-network hydrogel for use as a potential wound-healing material for the sustainable release of drugs.

Treating chronic wounds poses significant challenges in clinical medicine due to bacterial infection, reactive oxygen species (ROS) accumulation, and excessive inflammation. This study aimed to address these issues by developing a wound dressing with antibacterial, antioxidant, and anti-inflammatory properties. Chitosan was functionally modified with acrolein to covalently bind to epigallocatechin gallate (EGCG), enabling a high EGCG load.

Electrochemically Gated Frustrated Lewis Pair Chemistry in Electric Double Layer.

The recent discovery of frustrated Lewis pairs (FLPs) during the activation of small molecules has inspired extensive research across the full span of chemical science. Owing to the nature of weak interactions, it is experimentally challenging to directly observe and modulate FLP at the molecular scale. Here we design a boron cluster anion building block (BH ) and organic amine cations ([NR], R=-CH, -CH) as the FLP to prove the feasibility of controlling their interaction in the electric double layer (EDL) via an electrochemical strategy.

Identification of miR-1 and miR-499 in chronic atrial fibrillation by bioinformatics analysis and experimental validation.

Background: Atrial fibrillation (AF) is one of the most prevalent arrhythmias and is characterized by a high risk of heart failure and embolic stroke, yet its underlying mechanism is unclear. The primary goal of this study was to establish a miRNA-mRNA network and identify the miRNAs associated with chronic AF by bioinformatics and experimental validation.

Methods: The GSE79768 dataset was collected from the Gene Expression Omnibus(GEO) database to extract data from patients with or without persistent AF.

Application of Electrophysiological Techniques in Assessing of Neuromuscular Junction-Related Disorders.

This review aims to comprehensively summarize the application of electrophysiological methods, specifically repetitive nerve stimulation (RNS) and single fiber electromyography (SFEMG), in the diagnosis of neuromuscular junction (NMJ) disorders, including myasthenia gravis, Lambert-Eaton syndrome, and sarcopenia in the elderly. Both RNS and SFEMG have demonstrated high sensitivity and specificity in detecting NMJ abnormalities. RNS aids in distinguishing presynaptic from postsynaptic lesions, while SFEMG provides direct evidence of NMJ function by assessing single motor unit action potentials.

Off-axis telescope misalignment correction based on defocus spot moment features.

Optical mirror misalignments, which are caused by assembly mistakes and changes in the surrounding environment (such as gravity, temperature, and atmosphere), degrade the system's imaging performance. Therefore, active misalignment correction is essential for ensuring the image quality of the off-axis telescope. In this paper, a novel misalignment correction method without wavefront sensors is proposed.

β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation.

Aims: The mechanisms regulating the cellular behaviour and cardiomyocyte organization during ventricular wall morphogenesis are poorly understood. Cardiomyocytes are surrounded by extracellular matrix (ECM) and interact with ECM via integrins. This study aims to determine whether and how β1 integrins regulate cardiomyocyte behaviour and organization during ventricular wall morphogenesis in the mouse.

Effects of Connectivity Isomerization on Electron Transport Through Thiophene Heterocyclic Molecular Junction.

Connectivity isomerization of the same aromatic molecular core with different substitution positions profoundly affects electron transport pathways and single-molecule conductance. Herein, we designed and synthesized all connectivity isomers of a thiophene () aromatic ring substituted by two dihydrobenzo[b]thiophene () groups with ethynyl spacers (,-TP-BT, (, = 2,3; 2,4; 2,5; 3,4)), to systematically probe how connectivity contributes to single-molecule conductance. Single-molecule conductance measurements using a scanning tunneling microscopy break junction (STM-BJ) technique show ∼12-fold change in conductance values, which follow an order of 10 () < 10 () < 10 () < 10 ().

Transcriptomic analysis of epicardial adipose tissue reveals the potential crosstalk genes and immune relationship between type 2 diabetes mellitus and atrial fibrillation.

Background: The complex relationship between atrial fibrillation (AF) and type 2 diabetes mellitus (T2DM) suggests a potential role for epicardial adipose tissue (EAT) that requires further investigation. This study employs bioinformatics and experimental approaches to clarify EAT's role in linking T2DM and AF, aiming to unravel the biological mechanisms involved.

Method: Bioinformatics analysis initially identified common differentially expressed genes (DEGs) in EAT from T2DM and AF datasets.

Liquid crystal wavefront correction based on improved machine learning for free-space optical communication.

In order to suppress the impact of atmosphere turbulence on the space laser communication link, the wavefront correction technology of a liquid crystal spatial light modulator (LCSLM) is studied. Combining with the control mode of the LCSLM, we propose an improved deep learning approach that restores the input image features into the wavefront and then controls the LCSLM to compensate for the phase distortion. This method does not have Zernike coefficient truncation and does not require the calculation of coefficient matrices, thus improving the accuracy and efficiency of the algorithm.

Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.

Background: Catheter-based pulmonary vein isolation (PVI) is an effective and well-established intervention for symptomatic paroxysmal atrial fibrillation (PAF). Nevertheless, late recurrences of atrial fibrillation (LRAF) occurring during 3 to 12 months are common, and the underlying mechanisms remain elusive. Circular RNAs (circRNAs) in atrial tissue have been linked to the pathophysiological mechanisms and progression of PAF in a few studies.

Simultaneous removal of phosphate and tetracycline using LaFeO functionalised magnetic biochar by obtained ultrasound-assisted sol-gel pyrolysis: Mechanisms and characterisation.

Excessive phosphate and tetracycline (TC) contaminants pose a serious risk to human health and the ecological environment. As such exploring the simultaneous adsorption of phosphate and TC is garnering increasing attention. In this study, an efficient lanthanum ferrate magnetic biochar (FLBC) was synthesised from crab shells using an ultrasound-assisted sol-gel method to study its performance and mechanisms for phosphate and TC adsorption in aqueous solutions in mono/bis systems.

Jasmine waste derived biochar as green sulfate catalysts dominate non-free radical paths efficiently degraded tetracycline.

Because of the potential environmental harm caused by the extensive application of tetracycline (TC), this study used jasmine waste rich in organic matter as a precursor and one-step carbonization into metal-free carbon-based materials to efficiently activate peroxymonosulfate (PMS) toward degrading TC. The jasmine waste biochar (JWB) with a heating rate of 10 °C min and a heating temperature of 700 °C was selected as the most suitable material based on its catalytic performance. The effects of catalyst dose, PMS dose, initial pH value, coexisting inorganic anions and TC concentration on the JWB/PMS/TC system were thoroughly optimized.

Compassionate Use of Contezolid for the Treatment of Tuberculous Pleurisy in a Patient with a Leadless Pacemaker.

We report the case of an 87-year-old woman with tuberculous pleurisy. She developed adverse effects in the form of thrombocytopenia and gastrointestinal hemorrhage with isoniazid, and thrombocytopenia with linezolid. Her treatment was switched to contezolid plus cycloserine for a 4-week antibiotic duration, with a favorable outcome.

Design of a naphthalimide-based probe for acrolein detection in foods and cells.

Acrolein is a highly toxic agent that can be generated exogenously and endogenously. Therefore, a highly specific and sensitive probe for acrolein with potential applications in acrolein detection must be developed. In this research, a novel fluorescent probe named "probe for acrolein detection" (Pr-ACR) was designed and synthesized based on a naphthalimide fluorophore skeleton, and a thiol group (-SH) was introduced into its structure for acrolein recognition.

EEMD and Multiscale PCA-Based Signal Denoising Method and Its Application to Seismic P-Phase Arrival Picking.

Signal denoising is one of the most important issues in signal processing, and various techniques have been proposed to address this issue. A combined method involving wavelet decomposition and multiscale principal component analysis (MSPCA) has been proposed and exhibits a strong signal denoising performance. This technique takes advantage of several signals that have similar noises to conduct denoising; however, noises are usually quite different between signals, and wavelet decomposition has limited adaptive decomposition abilities for complex signals.

The effects of exopolysaccharides and exopolysaccharide-producing Lactobacillus on the intestinal microbiome of zebrafish (Danio rerio).

Background: Numerous studies have reported the health-promoting effects of exopolysaccharides (EPSs) in in vitro models; however, a functional evaluation of EPSs will provide additional knowledge of EPS-microbe interactions by in vivo intestinal microbial model. In the present study, high-throughput amplicon sequencing, short-chain fatty acid (SCFAs) and intestinal inflammation evaluation were performed to explore the potential benefits of exopolysaccharides (EPSs) and EPS-producing Lactobacillus (HNUB20 group) using the healthy zebrafish (Danio rerio) model.

Results: The results based on microbial taxonomic analysis revealed that the abundance of four genera, Ochrobactrum, Sediminibacterium, Sphingomonas and Sphingobium, were increased in the control group in comparison to HNUB20 group.

TRC-Based High-Precision Spot Position Detection in Inter-Satellite Laser Communication.

Inter-satellite laser communication (Is-OWC) is one of the main space optical communication technologies currently studied in various countries. In recent years, a kind of Is-OWC communication terminal without independent beacon light has appeared. Such terminals do not have a separate beacon laser with a large divergence angle, but use a narrower communication beam to complete space capture and tracking.

The scavenging capacity of γ-aminobutyric acid for acrolein and the cytotoxicity of the formed adduct.

Acrolein is a notorious aldehyde with hazardous impacts on humans. γ-Aminobutyric acid (GABA) is a functional amino acid present widely in foods. This study aimed at investigating the protective mechanism of GABA against acrolein.

Amplitude reduction of autonomic nerve function is correlated with ablation lesion quality in patients with paroxysmal atrial fibrillation.

Objective: Circumferential pulmonary vein isolation (CPVI) is a common procedure that is performed on patients with atrial fibrillation (AF). However, AF may recur in some patients after treatment. This study assesses the association between autonomic modulation and late recurrence after CPVI and between autonomic modulation and ablation lesion quality.

An Improved Method of Measuring Wavefront Aberration Based on Image with Machine Learning in Free Space Optical Communication.

In this paper, an improved method of measuring wavefront aberration based on image with machine learning is proposed. This method had better real-time performance and higher estimation accuracy in free space optical communication in cases of strong atmospheric turbulence. We demonstrated that the network we optimized could use the point spread functions (PSFs) at a defocused plane to calculate the corresponding Zernike coefficients accurately.

Improved Machine Learning Approach for Wavefront Sensing.

In the adaptive optics (AO) system, to improve the effectiveness and accuracy of wavefront sensing-less technology, a phase-based sensing approach using machine learning is proposed. In contrast to the traditional gradient-based optimization methods, the model we designed is based on an improved convolutional neural network. Specifically, the deconvolution layer, which reconstructs unknown input by measuring output, is introduced to represent the phase maps of the point spread functions at the in focus and defocus planes.

[The relationship between high-sensitivity C-reactive protein (hsCRP) levels and atrial fibrillation early recurrence after paroxysmal atrial fibrillation radiofrequency catheter ablation].

Objective: To prospectively clarify the predictive value of high-sensitivity C-reactive protein (hsCRP) on the risk for recurrent atrial arrhythmia in paroxysmal atrial fibrillation (PAF) population who accepted radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF).

Methods: There were 57 consecutive patients (53.32±9.

Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Electrophysiological characteristics of paroxysmal atrial fibrillation originating from superior vena cava: a clinical analysis of 30 cases.

To analyze characteristics of electrocardiogram (ECG), electrophysiological intracardiac mapping and radiofrequency ablation (RF) of paroxysmal atrial fibrillation (PAF) originating from superior vena cava (SVC), aiming to investigate electrophysiological characteristics of PAF with SVC origin. Clinical data of 30 subjects (18 men and 12 women, aged, 58.6 ± 15.