Measuring the Effective Electro-Optic Coefficient of Low-Temperature-Prepared Lead Zirconate Titanate Thin Films.

Developing lead zirconate titanate (PZT)-based electro-optic (EO) modulators is vital for integrated photonics. The high annealing temperature required for the processing of PZT thin films restricts their compatibility with modern complementary metal-oxide-semiconductor (CMOS) technology. In this work, high-quality PZT films were fabricated on SiO/Si substrates at a low annealing temperature of 450 °C.

Regulation of CRISPR trans-cleavage activity by an overhanging activator.

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a system exhibits extraordinary capability in the field of molecular diagnosis and biosensing, attributed to its trans-cleavage ability. The precise modulation of performance has emerged as a significant challenge in advancing CRISPR technology to the next stage of development. Herein, we reported a CRISPR/Cas12a regulation strategy based on an overhanging activator.

Dietary Zinc activates the Nrf2 signaling pathway to inhibit pyroptosis and attenuate the lung inflammatory response in COPD.

Unlabelled: Pyroptosis and inflammation play crucial roles in the development of chronic obstructive pulmonary disease (COPD), and Zinc deficiency is commonly observed in COPD patients. In this study, we aimed to explore the impact of Zinc supplementation on pyroptosis and inflammation in a cigarette smoke (CS)-induced COPD mouse model, as well as the underlying mechanisms. The COPD mouse model was established through CS exposure, and mouse pulmonary epithelial cells (MLE-12) were exposed to cigarette smoke extract (CSE) to further validate the effects of Zinc supplementation.

The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling.

Purpose: Recurrent abortion(RA) is a prevalent adverse pregnancy event. Exosomes, secreted by various body fluids, are known to play a role in disease diagnosis and serve as biomarkers through intercellular communication. This study aims to analyze single exosomes in patients with recurrent abortion to identify new biomarkers that may significantly contribute to recurrent abortion, providing new directions for its treatment.

The utility of ultrasound-guided percutaneous needle biopsy for diagnosis of peripheral pulmonary lesions: A retrospective cohort study.

Objective: The aim of this study was to explore the diagnostic accuracy of ultrasound-guided (US-guided) percutaneous needle biopsy (PNB) and related influencing factors that could provide references for clinicians to improve the diagnostic accuracy of peripheral pulmonary lesions (PPLs).

Methods: We retrospectively analyzed 318 consecutive cases with PPLs who underwent US-guided PNB successfully in Chongqing Red Cross Hospital, Fusheng Community Health Service Center, Maoershi Community Health Service Center, and Yuzui Community Health Service Center. We collected pathological results of ultrasound-guided biopsy, clinical final diagnosis, disease course records, and postoperative complications of these patients.

Effectiveness of an Internet-Based, Self-Guided, Short-Term Mindfulness Training (ISSMT) Program for Relieving Depressive Symptoms in the Adult Population in China: Single-Blind, Randomized Controlled Trial.

Background: Depression is a significant global public health issue, and in China, access to mental health services remains limited despite high demand. Research has shown that mindfulness can effectively alleviate depressive symptoms and that telehealth solutions offer a promising avenue for addressing this service gap. Despite this potential, there are currently few studies in China focusing on short-term online mindfulness training.

Logical Analysis of Multiple miRNAs with Isothermal Molecular Classifiers Based on LATE-RCA.

Logical analysis of multiple-miRNA expression information and immediate output of diagnostic results facilitates early cancer detection. In this work, we constructed an isothermal molecular classifier capable of performing computations on multiple miRNAs and directly providing diagnosis results. First, we developed linear-after-the-exponential rolling circle amplification (LATE-RCA), a nearly linear isothermal amplification that does not destroy the original quantitative information about miRNAs.

Engineering thermostable fluorescent DNA aptamer for the isothermal amplification of nucleic acids.

Isothermal amplification-based nucleic acid detection technologies have become rapid and efficient tools for molecular diagnostics. Sequence-specific monitoring methods are crucial for isothermal amplification, as they help identify the occurrence of extended primer dimers, which can lead to false positive results. Fluorescent aptamers are promising tools for real-time monitoring of isothermal amplification but are inherently limited by thermostability.

Mitogenome Phylogenetics of Spiruromorpha Porpoise Parasite: Insights Into Phylogeny of .

(1) Background: is a major parasite of large porpoises and whales and has been classified in the Habronematoidea family. However, there has been a great controversy regarding its classification. Mitochondria have an important function in revealing taxonomic and evolutionary history.

Tris(2-chloroethyl) Phosphate Leads to Unbalanced Circulating Erythrocyte in Mice by Activating both Medullary and Extramedullary Erythropoiesis.

Tris(2-chloroethyl) phosphate (TCEP), a prevalent organophosphorus flame retardant, has been identified in various environmental matrices and human blood samples, provoking alarm regarding its hematological toxicity, a subject that has not been thoroughly investigated. Red blood cells (RBCs), or erythrocytes, are the predominant cell type in peripheral blood and are crucial for the maintenance of physiological health. This investigation employed oral gavage to examine the effects of TCEP exposure on erythrocyte counts in mice and to clarify the underlying mechanisms.

Gel properties of sheep's hoof gelatin-dietary polysaccharide interpenetrating polymer network complex gels with application in low fat lamb patties.

In order to explore new fat substitutes, we compared three dietary polysaccharides Pectin(PEC), Inulin (INU), and Konjac glucomannan (KGM) compounded with sheep hoof gelatin using different cross-linking methods [transglutaminase (Tg) enzyme; Tg enzyme & Ca] for the preparation of Semi-interpenetrating polymer network (Semi-IPN) and fully interpenetrating polymer network (IPN) gels. The optimal ratio was determined by comprehensively evaluating the addition of hydrogel to the lamb patties at different ratios. The results showed that PEC-IPN exhibited superior stability and textural properties compared to the Semi-IPN gels and control gels in each group.

High-visibility calculating ghost imaging with self-reconstruction capability and extendible depth-of-field.

We customized light speckle fields with both super-bunching and non-diffracting properties, accordingly named as the super-bunching, non-diffracting (SP-ND) speckle fields, by introducing pupil function of a ring aperture with azimuthally correlated phases in the vertically opposite angles. Calculating ghost imaging based on the SP-ND speckle fields was demonstrated to be of higher visibility, higher spatial resolution and larger depth of field than that based on the conventional speckle fields such as pseudo-thermal fields. Interestingly, the SP-ND speckles are also of self-healing capability in respect of not only the speckle intensity distribution but also the high-order coherence properties.

Two versus three to four cycles of neoadjuvant immunochemotherapy for locally advanced esophageal squamous cell carcinoma in real-world practice.

Background: There is currently no consensus on whether intensive cycles of neoadjuvant immunochemotherapy provide greater benefit than do less intensive cycles (two cycles) in esophageal cancer (EC). Therefore, in this study, we assessed the efficacy and safety of three to four cycles of neoadjuvant immunochemotherapy compared to two cycles for treating patients with locally advanced esophageal squamous cell carcinoma (ESCC).

Methods: This is a retrospective study of patients enrolled on previous clinical studies involving locally/regionally advanced ESCC (St.

Hsa_circ_0109320 Serves as a Novel Circular RNA Biomarker in Non-small Cell Lung Cancer by Promoting Metastasis.

Non-small cell lung cancer (NSCLC), including squamous cell carcinoma and adenocarcinoma, ranks among the top 10 cancers worldwide in terms of prevalence and mortality. NSCLC, a highly malignant tumor, exhibits distant invasion and migration as well as an unfavorable prognosis. As an innovative circular RNA, hsa _circ_0109320 (circ_0109320) has been recognized as a promising cancer modulator.

Evaluation of the efficacy of disinfectants and disinfection methods against Ascaris suum eggs.

Ascaris is highly adaptable, allowing its offspring to thrive in various conditions and posing significant health risks widely among animal populations. Most studies regarding the efficacy of disinfectants against Ascaris eggs in animal houses have been limited and lack a systematic and comprehensive evaluation. Currently, Ascaris suum is one of the most extensively studied helminths in the context of parasitology.

Selective SERS Sensing of R6G Molecules Using MoS Nanoflowers under Pressure.

Pressure-induced surface-enhanced Raman spectroscopy (PI-SERS) has garnered significant attention as a subfield of SERS detection due to its capacity to regulate the band gap between molecules and substrates through pressure modulation. Currently, SERS detection primarily focuses on single molecules at atmospheric pressure with limited investigations conducted under high pressure conditions. Herein, we employed rose-shaped MoS nanoflowers as the SERS substrate and realized selective PI-SERS enhancement of R6G molecules in the binary (MV+R6G) and ternary (MV+R6G+RhB) systems.

Comparative Efficacy of Acute Exercise Intervention on Anxiety in Adolescents and Young Adults: A Network Meta-Analysis.

Acute exercise is a promising non-pharmacological therapy for alleviating anxiety. However, the effects of different types of acute exercise on anxiety in adolescents and young adults remain unclear. Therefore, our study aims to conduct a network meta-analysis to compare the effectiveness of various exercise interventions in improving anxiety in adolescents and young adults.

[Mechanism of ganoderic acid X in treating hepatoblastoma based on proteomics].

This research explored the mechanism of ganoderic acid X(GAX) on human hepatocellular carcinoma cell models(HepG2, HuH6) and nonobese diabetic-severe combined immune deficient(NOD-SCID) mouse subcutaneous tumor models using proteomics, aiming to provide a basis for the clinical application of GAX. CCK-8 assay was employed to evaluate the effect of GAX on the viability of HepG2 and HuH6 cells. EdU assay was used to assess the effect of GAX on cell proliferation.

Origin and Geochemical Characterization of Groundwater from Coal Seam: A Case Study of Balasu Coalfield, Ordos Basin.

The hydrochemical characteristics of groundwater are of great significance for studying the source, development, and utilization of groundwater. This study investigated the characteristics of anions and cations, total dissolved solids (TDS), hydrochemical types, and hydrogen and oxygen isotopes of surface water and groundwater in the Balasu coalfield. By conducting experiments using inductively coupled plasma emission electron spectrometry, ion chromatography, acid-base titration, and gravimetric analysis, the characteristics of ion concentration and TDS in different aquifers were analyzed to determine the possible source of groundwater in C2 (number 2 coal seam in Yan'an Formation).

AND Logic-Gate-Based Dual-Locking Probe System for the Sensitive Detection of microRNA and APE1.

MicroRNA (miRNA) and apurinic/apyrimidinic endonuclease 1 (APE1) have been reported to be closely associated with cancers, making them potential crucial biomarkers and therapeutic targets. However, focusing on the detection of a single target is not conducive to the diagnosis and prognosis assessment of diseases. In this study, an AND logic-gate-based dual-locking hairpin-mediated catalytic hairpin assembly (DL-CHA) was developed for sensitive and specific detection of microRNA and APE1.

Physical activity and self-efficacy in college students: the mediating role of grit and the moderating role of gender.

Background: There is a paucity of knowledge concerning the psychological variables that serve to facilitate the connection between physical activity and self-efficacy, and the factors capable of moderating these pathways. This study aimed to examine the relationship between physical activity and self-efficacy among college students, with a focus on the mediating effect of grit and the moderating effect of gender.

Methods: This study recruited 3,228 undergraduate students from a university in Shanghai, China.

An esophagectomy surgical Apgar score-based nomogram-a risk-based postoperative triage system: a phase II randomised trial.

Background: The esophagectomy surgical Apgar score (eSAS) has been found to be a predictor of postoperative complications in esophagectomy. In our previous study, we built a graphic nomogram based on eSAS and demonstrated that it can effectively predict the risk of major morbidity after esophagectomy. In this study, we aimed to assess the benefits of using an eSAS-based nomogram model as a postoperative risk-based triage system for patients undergoing esophagectomy.