Patterns of recurrence after esophagectomy following neoadjuvant immunochemotherapy in patients with thoracic esophageal squamous cell carcinoma.

Purpose: To explore the recurrence pattern and risk factors associated with the relapse of thoracic esophageal squamous cell carcinoma (TESCC) among patients who received esophagectomy following neoadjuvant immunochemotherapy (NICT).

Methods: A total of 191 TESCC patients who received esophagectomy following NICT were retrospectively reviewed from 2019 to 2022. The first recurrence patterns were assessed.

[Clinical significance of antiphospholipid antibodies in Behcet disease with thrombosis].

Objective: To investigate the distribution and clinical significance of antiphospholipid antibody (aPL) in patients with Behcet disease (BD).

Methods: A total of 222 BD patients admitted to the Department of Rheumatology and Immunology in Peking University People' s Hospital from February 2008 to July 2024 were selected retrospectively. General data of the patients including age and gender were collec-ted.

[Ovarian function in patients of childbearing age with systemic lupus erythematosus].

Objective: To explore the ovarian function and its influencing factors in women of childbearing age with systemic lupus erythematosus (SLE).

Methods: A total of 107 female patients diagnosed with SLE at Peking University People' s Hospital from January 2017 to May 2024, aged between 20 and 40 years, were included in the study. At the same time, 40 matched healthy women aged between 20 and 40 years were selected as controls.

[Analysis of characteristics related to the disease activity of systemic lupus erythematosus and construction of an evaluation model].

Objective: To stratify systemic lupus erythematosus (SLE) patients clinically, to analyze the clinical characteristics of patients with and without disease activity, and to explore the application va-lue of key clinical indicators in assessing disease activity, as well as to construct an evaluation model.

Methods: A retrospective analysis was conducted on clinical data of the SLE patients diagnosed at Peking University People' s Hospital from May 1995 to April 2014. Demographic information, clinical manifestations, laboratory tests, and antibody detection results were collected.

Deep Fusion of Skeleton Spatial-Temporal and Dynamic Information for Action Recognition.

Focusing on the issue of the low recognition rates achieved by traditional deep-information-based action recognition algorithms, an action recognition approach was developed based on skeleton spatial-temporal and dynamic features combined with a two-stream convolutional neural network (TS-CNN). Firstly, the skeleton's three-dimensional coordinate system was transformed to obtain coordinate information related to relative joint positions. Subsequently, this relevant joint information was encoded as a color texture map to construct the spatial-temporal feature descriptor of the skeleton.

Agile control of test mass based on PINN-DDPG for drag-free satellite.

Agile control after the release of test mass is related to the success or failure of China's space gravitational wave detection program, such as TianQin and Taiji. In the release process, the test mass's motion state is complex and susceptible to collisions with the satellite cavity. In addition, the release capture control of the test mass uses electrostatic force, which is extremely small.

Repression of JAK2-STAT1 and PD-L1 by CEP-33779 ameliorates the LPS-induced decline in phagocytic activity of alveolar macrophages and mitigates lung injury in mice.

Background: The role of the JAK2-STAT1/PD-L1 pathway in the phagocytic activity of alveolar macrophages (AMs) during LPS-induced acute lung injury in mice remains poorly understood. This study aims to explore whether the JAK2-STAT1/PD-L1 pathway is upregulated on AMs in LPS-induced mice acute lung injury and to further explore the impact of the JAK2-specific inhibitor CEP-33779 on the LPS-induced impairment of AMs phagocytic activity and lung injury.

Methods: ALI was induced in mice via intratracheal administration of LPS, followed by intragastric administration of JAK2 inhibitor CEP-33779 suspension.

A Novel Ultrasonographic Method to Quickly and Accurately Access the C2 Dorsal Root Ganglion.

Background: Occipital neuralgia manifests as pain in the cutaneous distribution of occipital nerves, with the greater occipital nerve stemming from the C2 spinal nerve and the lesser occipital nerve originating from the C2 and C3 spinal nerves. While pulsed radiofrequency ablation of the C2 dorsal root ganglion (DRG) is an effective treatment for refractory occipital neuralgia, accessing the C2 DRG remains a clinical challenge even under fluoroscopic guidance.

Objective: We aimed to develop an ultrasonographic method for quickly and accurately accessing the C2 DRG.

Lifestyle Profile Scale for Gravida with Urinary Incontinence: scale development and psychometric testing in Chinese Mainland.

Objectives: A significant number of women may experience urinary incontinence (UI) during pregnancy. While lifestyle modifications are recommended as important measures for preventing and treating UI, little is known about the lifestyle status of gravida with UI. This study aimed to develop the Lifestyle Profile Scale for Gravida with Urinary Incontinence (LPG-UI) and to evaluate its psychometric properties.

Integrative analysis identifies the atypical repressor E2F8 as a targetable transcriptional activator driving lethal prostate cancer.

Acquired resistance to androgen receptor (AR)-targeted therapies underscores the need to identify alternative therapeutic targets for treating lethal prostate cancer. In this study, we evaluated the prognostic significance of 1635 human transcription factors (TFs) by analyzing castration-resistant prostate cancer (CRPC) datasets from the West and East Stand Up to Cancer (SU2C) cohorts. Through this screening approach, we identified E2F8, a putative transcriptional repressor, as a TF consistently associated with poorer patient outcomes in both cohorts.

DNA breakpoints and free DNA fragments as potential predictors of infertility.

The study investigated the impact of varicocele on male infertility by analyzing sperm samples from 42 varicocele patients and 22 healthy individuals. Basic sperm parameters such as concentration and vitality were assessed, along with the DNA Fragmentation Index (DFI) using the SCSA method. Additionally, the mean number of sperm DNA breaks (MDB) and free DNA fragments amount in seminal plasma (fDFA) were analyzed using the TDT-Strand Displacement Probe Technique.

Enhanced adhesive hydrogel for emergency hemostasis by balancing adhesion and cohesion.

Hydrogel adhesives have broad application prospects in biomedical fields such as tissue engineering and emergency rescue. However, due to the high water content and defective network structure, their inherent mechanical strength is low, which seriously hinders their application. In the present work, enhanced adhesive hydrogels could be synthesized by balancing cohesion and adhesion forces.

Complete genome sequence of " Dehalogenimonas loeffleri" strain W, a highly salt-tolerant chlorinated alkane-dechlorinating bacterium isolated from estuarine sediments.

Dehalogenimonas loeffleri" strain W, isolated from estuarine sediments, can dechlorinate 1,2-dichloroethane under high salinity. Its genome consists of a circular 1,772,240-bp chromosome with a G + C content of 52.5% and encompasses 1,763 protein-coding sequences, including 28 genes encoding reductive dehalogenases.

Predictive Value of dsDNA and Nucleosomes as Neutrophil Extracellular Traps-Related Biomarkers for COVID-19 in Older Patients.

Background: Previous studies have demonstrated that neutrophil extracellular traps (NETs) are crucial in infectious diseases. This study aims to evaluate the clinical value of NET-related biomarkers in identifying the risk of COVID-19 and diagnosing the disease.

Methods: This study involved 32 patients who tested positive for COVID-19 via polymerase chain reaction (PCR) between April and August 2023.