The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma.

Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested that AKR1B10 is a new biomarker for cancer based on its overexpression in epithelial tumors, such as breast cancer, cervical cancer, and lung cancer. At present, studies on the expression of AKR1B10 in laryngeal cancer have not been reported.

N'-(3-Bromo-5-chloro-2-hy-droxy-benzyl-idene)-2H-1,3-benzodioxole-5-carbo-hydrazide.

The asymmetric unit of the title hydrazone compound, C(15)H(10)BrClN(2)O(4), contains two independent mol-ecules. The dihedral angles between the benzene rings are 38.7 (3)° in one mol-ecule and 24.

(E)-N'-(5-Bromo-2-meth-oxy-benzyl-idene)isonicotinohydrazide.

The asymmetric unit of the title compound, C(14)H(12)BrN(3)O(2), contains two independent mol-ecules in which the dihedral angles between the benzene ring and the pyridine ring are 24.4 (6) and 23.7 (6)°.

(E)-4-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide methanol monosolvate.

The hydrazone mol-ecule of the title compound, C(15)H(13)N(3)O(4)·CH(4)O, is nearly planar, with a dihedral angle between the two benzene rings of 1.2 (4)°. The mol-ecule exists in a trans configuration with respect to the central methyl-idene unit.

(E)-2-Fluoro-N'-(4-nitro-benzyl-idene)benzo-hydrazide.

In the title hydrazone compound, C(14)H(10)FN(3)O(3), the dihedral angle between the two substituted benzene rings is 13.7 (3)°. The mol-ecule exists in a trans configuration with respect to the central methyl-idene unit.

(E)-4-Hydr-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide.

The mol-ecule of the title compound, C(14)H(11)N(3)O(4), is approximately planar, the dihedral angle between the planes of the two substituted benzene rings being 2.54 (7)°. The mol-ecule exists in a trans configuration with respect to the central methyl-idene unit.

(E)-N'-(4-Hydroxy-benzyl-idene)-4-hydroxy-benzohydrazide methanol solvate.

The title compound, C(14)H(12)N(2)O(3)·CH(4)O, consists of a Schiff base mol-ecule and a methanol mol-ecule of crystallization. The Schiff base mol-ecule is nearly planar, the dihedral angle between the planes of the two benzene rings being 7.2 (2)°.

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-3-methoxy-benzohydrazide.

In the title compound, C(16)H(15)BrN(2)O(3), there are two independent mol-ecules (A and B) in the asymmetric unit. The major difference between the two mol-ecules is the dihedral angle formed by the aromatic rings [72.6 (2) and 18.

(E)-N'-[1-(2-Hydroxy-phen-yl)ethyl-idene]-3-methoxy-benzohydrazide.

In the title compound, C(16)H(16)N(2)O(3), the benzohydrazide group is not planar and the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two substituted benzene rings is 26.9 (2)°.

(E)-2-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide.

In the title compound, C(15)H(13)N(3)O(4), the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two benzene rings is 6.8 (2)°.

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-4-methoxy-benzohydrazide.

In the title compound, C(16)H(15)BrN(2)O(3), the benzohydrazide group is not planar and the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two substituted benzene rings is 75.6 (2)°.

(E)-N'-(2-Chloro-5-nitro-benzyl-idene)-4-methoxy-benzohydrazide.

In the title compound, C(15)H(12)ClN(3)O(4), the benzohydrazide group is not planar and the mol-ecule exists in a trans configuration with respect to the methyl-idene unit. The dihedral angle between the two substituted benzene rings is 0.4 (3)°.