[Acupuncture combined with bamboo-based medicinal moxibustion for chronic insomnia complicated with mild depressive state: a randomized controlled trial].

Objective: To observe the clinical efficacy of acupuncture combined with bamboo-based medicinal moxibustion in the treatment of chronic insomnia complicated with mild depressive state.

Methods: A total of 60 patients with chronic insomnia complicated with mild depressive state were randomly divided into an observation group and a control group, 30 cases in each group. The control group was treated with acupuncture at bilateral Zhaohai (KI6), Shenmen (HT7), Sanyinjiao (SP6), Anmian (Extra) and Sishencong (EX-HN1), Baihui (GV20), etc.

Polyketide Synthase Acyltransferase Domain Swapping for Enhanced EPA Recognition and Efficient Coproduction of EPA and DHA in sp.

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are important polyunsaturated fatty acids (PUFAs) used as nutritional supplements. The natural EPA content in sp. is low, and traditional strategies to increase EPA levels often compromise DHA content or lipid accumulation, hindering industrial coproduction.

Diversity of Parasitoid Wasps and Comparison of Sampling Strategies in Rice Fields Using Metabarcoding.

A comprehensive and precise evaluation of Arthropoda diversity in agricultural landscapes can enhance biological pest control strategies. We used Malaise traps and sweep nets to collect insects from three double-cropping paddy fields. DNA was extracted from the ethanol preservative of the Malaise traps and from tissue samples of selected parasitoid wasps.

Microscopic characteristics and sources of atmospheric dustfall in open-pit mining coal resource-based city in the arid desert area of Northwest China.

Atmospheric dustfall is solid air pollutant, has a major impact on the environment and human health. The objective of this study was to investigate the microscopic characteristics and sources of atmospheric dustfall in open-pit mining coal resource-based city in the arid desert area of Northwest China. The characteristics of size and shape factors, variation of shape factors with size distribution, types of individual particles, and sources of atmospheric dustfall, which were collected in the open-pit mining area and surrounding areas, were analyzed by X-ray diffraction (XRD) and scanning electron microscopy coupled with an energy dispersive spectrometer (SEM-EDS) combined with graphical method and shape factors.

Clinical value of the prognostic nutritional index and red blood cell distribution width-to-albumin ratio for the prediction of severity of and mortality associated with Stevens-Johnson syndrome/toxic epidermal necrolysis.

The prognostic nutritional index (PNI) and red blood cell distribution width-to-albumin ratio (RAR) are considered to be related to the prognosis of disease severity. However, the role of these biomarkers in predicting Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) severity and mortality is unclear. The aim of the current study was to investigate the association of PNI and RAR with severity and mortality in individuals with SJS/TEN.

Engineering Metabolic Pathways for Cofactor Self-Sufficiency and Serotonin Production in .

Serotonin is a neurotransmitter that plays an essential regulatory role in numerous cognitive and behavioral functions. Recent advances in synthetic biology have enabled engineering of non-natural biosynthetic pathways for serotonin production in . Here, an optimized heterologous serotonin biosynthetic pathway was engineered in and coupled with the biosynthetic and regeneration modules of the endogenous vital cofactor tetrahydrobiopterin (BH4) for efficient serotonin production using whole-cell catalysis.

Long-Noncoding RNA ANCR Activates the Hedgehog Signaling Pathway to Promote Basal Cell Carcinoma Progression by Binding to PTCH.

Purpose: The long non-coding RNA (lncRNA) anti-differentiation noncoding RNA (ANCR) is closely related to the occurrence and development of various malignancies. However, its expression and potential role in basal cell carcinoma (BCC) have not been established. In this study, we characterized the effects of ANCR in BCC and its underlying mechanism.

Ferroptosis-related local immune cytolytic activity in tumor microenvironment of basal cell and squamous cell carcinoma.

Background: Ferroptosis, a recently discovered form of cell death, whose role in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) has not been well disclosed. To improve our understanding of the differences in tumor progression and therapeutic effects between BCC and SCC, and to find potential therapeutic targets, this study systematically analyzed ferroptosis-related genes (FRGs) and their associated local immune cytolytic activity (LICA) and tumor microenvironment (TME) metabolic function differences.

Methods: Two bulk RNA-seq datasets, GSE7553 and GSE125285, from the Gene Expression Omnibus database were compared within and between groups to screen for common differentially expressed genes (DEGs) for enrichment analysis.

Source apportionment and health risk due to PM and TSP at the surface workings of an underground coal mine in the arid desert region of northwestern China.

The surface operations area of an underground coal mine near Lingwu in Ningxia Hui Autonomous Region was selected for this study. Particulate matter (PM) was sampled in the coal screening plant during the day and night in Spring and Winter, 2019. Twelve trace metals and eight water-soluble ions in particulate matter up to 10 μm in diameter (PM) and total suspended particles (TSP) were analyzed using ICP-OES and ion chromatography, respectively.

High-Level Production of Indole-3-acetic Acid in the Metabolically Engineered .

Indole-3-acetic acid (IAA) is a critical plant hormone that regulates cell division, development, and metabolism. IAA synthesis in plants and plant-associated microorganisms cannot fulfill the requirement for large-scale agricultural production. Here, two novel IAA biosynthesis pathways, tryptamine (TAM) and indole-3-acetamide (IAM), were developed for IAA production by whole-cell catalysis and biosynthesis in an engineered MG1655.

[Characteristics and Source Apportionment of Dustfall Pollution in the Coal Mine Area and Surrounding Areas of Wuhai City in Spring].

To study the concentration levels, pollution characteristics of each functional area, and sources of pollutants of the dust heavy metals Al, As, Ba, Be, Cd, Co, Cr, Cu, Fe, Li, Mg, Mn, Ni, Pb, Sb, Ti, V, and Zn in spring in Wuhai, 43 groups of dust samples were collected from different locations within the city from March to June 2018. The heavy metal mass concentration was then measured using an inductively coupled plasma optical emission spectrometer (ICP-OES). The results showed that:①The average contents of As, Cd, Cu, Pb, Cr, Ni, Sb, and Zn were 408.

Enhancement of NADPH availability for coproduction of coenzyme Q and farnesol from Rhodobacter sphaeroides.

Coenzyme Q (CoQ)-an essential cofactor in the respiratory electron transport chain-has important pharmaceutical and healthcare applications. Farnesol (FOH)-an acyclic sesquiterpene alcohol-has garnered interest owing to its valuable clinical and medical benefits. Here, the coproduction of CoQ and FOH in Rhodobacter sphaeroides GY-2 was greatly improved through the enhancement of intracellular NADPH availability.

Large-scale synthesis of water-soluble nanowires as versatile templates for nanotubes.

This study presents a large-scale synthesis of water-soluble sodium fluosilicate (Na(2)SiF(6)) nanowires, which serve as a versatile template for producing nanotubes.