Modulation of PI3K/AKT/mTOR signaling pathway in the ovine liver and duodenum during early pregnancy.

The liver and intestine play a critical role in nutrient absorption, storage, and metabolism. The aim of this study was to evaluate expression pattern of phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signaling pathway that included PI3K, AKT1, mTOR, FoxO1, SREBP-1, PPARα, PTEN and FXR in the maternal liver and duodenum. Ovine livers and duodenums were sampled at day 16 of the estrous cycle, and at days 13, 16 and 25 of gestation, and RT-qPCR, western blot and immunohistochemistry analysis were used to detect mRNA and protein expression.

Efficient CO Capture and Separation in MOFs: Effect from Isoreticular Double Interpenetration.

Severe CO emissions has posed an increasingly alarming threat, motivating the development of efficient CO capture materials, one of the key parts of carbon capture, utilization, and storage (CCUS). In this study, a series of metal-organic frameworks (MOFs) named Sc-X (X = S, M, L) were constructed inspired by recorded MOFs, Zn-BPZ-SA and MFU-4l-Li. The corresponding isoreticular double-interpenetrating MOFs (Sc-X-IDI) were subsequently constructed via the introduction of isoreticular double interpenetration.

Effects of Shale Pore Size and Connectivity on scCO Enhanced Oil Recovery: A Molecular Dynamics Simulation Investigation.

The differences in pore width distributions and connectivity of shale reservoirs have significant influences on supercritical carbon dioxide (scCO)-enhanced oil recovery (CO EOR) in shale. Herein, the molecular dynamics simulation was adopted to investigate the microscopic mechanism of CO EOR in the shale nanopores with different pore size width distributions and pore connectivity. The results show that the pore connectivity has significant effects on the oil displacement, and the recovery efficiency is ordered as: connected pore > double pore > single pore for the 3 nm pore, which are 91.

Molecular Dynamics Insight into the CO Flooding Mechanism in Wedge-Shaped Pores.

Because of the growing demand for energy, oil extraction under complicated geological conditions is increasing. Herein, oil displacement by CO2 in wedge-shaped pores was investigated by molecular dynamics simulation. The results showed that, for both single and double wedge-shaped models, pore Ⅱ (pore size from 3 to 8 nm) exhibited a better CO2 flooding ability than pore Ⅰ (pore size from 8 to 3 nm).

Early Pregnancy Modulates Expression of the Nod-like Receptor Family in Lymph Nodes of Ewes.

NOD receptors (NLRs) mediate adaptive immune responses and immune tolerance. Nevertheless, it is not clear if gestation modulates the NLR signaling pathway in lymph nodes of ewes. In this study, lymph nodes of ewes were collected at day 16 of the estrous cycle, and at days 13, 16 and 25 of gestation ( = 6 for each group).