Zinc Enhances Cadmium Accumulation in Shoots of Hyperaccumulator by Improving ATP-Dependent Transport and Alleviating Toxicity.

is a cadmium (Cd) and zinc (Zn) accumulator with potential for phytoextraction of soil contaminated with heavy metals. However, how Zn affects Cd accumulation in remains unclear. In this study, seedlings were treated with 100 μmol·L Zn (Zn100), 100 μmol·L Cd (Cd100), and the Zn and Cd combination (Zn100+Cd100) for 10 days under hydroponic culture.

iTRAQ proteome analysis reveals the underling mechanisms of foliage zinc-spraying to improve photosynthetic capacity and seed yields of Peaonia ostii 'Fengdan'.

Zinc (Zn) deficiency is a significant nutritional limitation to crop yield globally, particularly in calcareous soil environments. Tree peony of Peaonia ostii 'Fengdan' is regarded as an oil crop due to its seeds rich in alpha-linolenic acid, a beneficial compound for health promotion. However, low seed yield remains a primary challenge in attaining sufficient seed oil from tree peony.

Acupressure: a possible therapeutic strategy for anxiety related to COVID-19: a meta-analysis of randomized controlled trials.

Background: From the end of 2019 to December 2023, the world grappled with the COVID-19 pandemic. The scope and ultimate repercussions of the pandemic on global health and well-being remained uncertain, ushering in a wave of fear, anxiety, and worry. This resulted in many individuals succumbing to fear and despair.

Cloning and Expression Analysis of Key Enzyme Gene Involved in Iridoid Glycoside Synthesis in .

Cornus iridoid glycosides (CIGs), including loganin and morroniside, are the main active components of . As one of the key enzymes in the biosynthesis of CIGs, geranyl pyrophosphate synthase (GPPS) catalyzes the formation of geranyl pyrophosphate, which is the direct precursor of CIGs. In this study, the geranyl pyrophosphate synthase (CoGPPS) sequence was cloned from and analyzed.

Radiomics signatures for predicting the Ki-67 level and HER-2 status based on bone metastasis from primary breast cancer.

This study explores the potential of radiomics to predict the proliferation marker protein Ki-67 levels and human epidermal growth factor receptor 2 (HER-2) status based on MRI images of patients with spinal metastasis from primary breast cancer. A total of 110 patients with pathologically confirmed spinal metastases from primary breast cancer were enrolled between Dec. 2017 and Dec.

Molecular mechanism of somatic embryogenesis in paeonia ostii 'Fengdan' based on transcriptome analysis combined histomorphological observation and metabolite determination.

Background: Tree peony (Paeonia sect. Moutan DC.) is a famous flower native to China with high ornamental, medicinal, and oil value.

Radiomics of Spinal Metastases Originating From Primary Nonsmall Cell Lung Cancer or Breast Cancer and Ability to Predict Epidermal Growth Factor Receptor Mutation/Ki-67 Levels.

Objectives: The aims of the study are to explore spinal magnetic resonance imaging (MRI)-based radiomics to differentiate spinal metastases from primary nonsmall cell lung cancer (NSCLC) or breast cancer (BC) and to further predict the epidermal growth factor receptor (EGFR) mutation and Ki-67 expression level.

Methods: In total, 268 patients with spinal metastases from primary NSCLC (n = 148) and BC (n = 120) were enrolled between January 2016 and December 2021. All patients underwent spinal contrast-enhanced T1-weighted MRI before treatment.

Response and Tolerance of to Excess Zinc Based on Transcriptome and Proteome Patterns.

is a dominant plant of mine tailings and a zinc (Zn) accumulator with high Zn tolerance. In this study, seedlings cultured in Hoagland solution were treated with 200 μmol·L of Zn for 1 day or 7 days, and then, their leaves were taken for a comparative analysis of the transcriptomes and proteomes between the leaves of the control and Zn treatments. Differentially expressed genes included those that were iron (Fe)-deficiency-induced, such as vacuolar iron transporter , ABC transporter and ferric reduction oxidase Those genes were significantly upregulated by Zn and could be responsible for Zn transport in the leaves of .

Physiological and molecular response and tolerance of Macleaya cordata to lead toxicity.

Background: Macleaya cordata is a traditional medicinal herb, and it has high tolerance and accumulation ability to heavy metals, which make it a good candidate species for studying phytoremediation. The objectives of this study were to investigate response and tolerance of M. cordata to lead (Pb) toxicity based on comparative analysis of transcriptome and proteome.

Food security and overuse of agrochemicals: evidence from China's major grain-producing areas policy.

China's major grain-producing areas (MGPA) policy is the core policy to ensure national food security. While achieving long-term stable growth of grain production, assessing the impact of MGPA policy on agrochemical application has important practical significance in sustainable agricultural development and environmental protection. Based on panel data of 31 provinces in China from 1997 to 2020 and taking the MGPA policy introduced in 2004 as a quasi-natural experiment, we construct a difference-in-difference (DID) model to evaluate the overall impact and dynamic effect of MGPA policy.

Oxidative Stress Response and Metal Transport in Roots of Exposed to Lead and Zinc.

Heavy metal pollution possesses potential hazards to plant, animal and human health, which has become the focus of recent attention. Hence, phytoremediation has been regarded as one of the most important remediation technologies for heavy-metal-contaminated soils. In this research, a dominant mine tailing plant, , was used as the experimental material to compare the metal transport and oxidative stress response in its roots under lead (Pb) and zinc (Zn) treatments.

Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study.

Context: The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited.

Objective: This study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the real world, as well as to examine the effects of dose on patient outcomes.

Design: A prospective, observational, posttrial study (NCT03290235).

Comparative Transcriptome Analysis of MeJA Responsive Enzymes Involved in Phillyrin Biosynthesis of .

Forsythia suspensa (Thunb.) has been widely used in traditional medicines in Asia. According to the 2020 edition of Chinese Pharmacopoeia, phillyrin is the main active ingredient in F.

Environmental effects of rural e-commerce: A case study of chemical fertilizer reduction in China.

The economic effects of rural e-commerce have been fully discussed by scholars, but few studies focus on the environmental effects of rural e-commerce. This study takes the reduced application of chemical fertilizer in China as an example. On the basis of constructing the corresponding theoretical framework, we take the promotion of Rural E-Commerce Demonstration County (REDC) policy as a quasi-natural experiment, using the county panel data from 2000 to 2020 and the multi-period difference-in-difference method to excavate the influence of rural e-commerce on the fertilizer reduction.

Anthocyanins accumulation analysis of correlated genes by metabolome and transcriptome in green and purple peppers (Capsicum annuum).

Background: In order to clarify the the molecular mechanism of anthocyanin accumulation in green and purple fruits of pepper using metabolomics and transcriptomics,to identify different anthocyanin metabolites,and to analyze the differentially expressed genes involved in anthocyanin biosynthesis..

Results: We analyzed the anthocyanin metabolome and transcriptome data of the fruits of 2 purple pepper and 1 green pepper.

Corrigendum: Reduced Effectiveness and Comparable Safety in Biweekly Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trial.

[This corrects the article DOI: 10.3389/fendo.2021.

Computational Insight Into Vitamin K ω-Hydroxylation by Cytochrome P450 4F2.

Vitamin K (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids. However, the mechanism of VK1 ω-hydroxylation by CYP4F2 has not been disclosed.

Several newly discovered Mo-enriched plants with a focus on Macleaya cordata.

Phytoremediation as an alternative strategy has been a widespread attention. The screening of enriched plants and hyperaccumulators is the key of the strategy. So this study examined the status of heavy metal pollution in molybdenum (Mo) mine soils, metal accumulation in plants growing on mine, and their tolerance strategies.

De novo transcriptomic analysis of leaf and fruit tissue of Cornus officinalis using Illumina platform.

Cornus officinalis is one of the most widely used medicinal plants in China and other East Asian countries to cure diseases such as liver, kidney, cardiovascular diseases and frequent urination for thousands of years. It is a Level 3 protected species, and is one of the 42 national key protected wild species of animals and plants in China. However, the genetics and molecular biology of C.

H₂O₂ Is Involved in the Metallothionein-Mediated Rice Tolerance to Copper and Cadmium Toxicity.

Cadmium (Cd) and excess copper (Cu) are toxic to plants, causing a wide range of deleterious effects including the formation of reactive oxygen species. Metallothioneins (MTs) may protect plant cells from heavy metal toxicity by chelating heavy metals via cysteine thiol groups. They may also function as antioxidants.