Publications by authors named "Hongxian Dong"
Article Synopsis
- - Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, characterized by a range of symptoms, genetic variations, and unpredictable progression, with recent advances in molecular genetics aiding in its understanding and classification.
- - Despite ongoing research into potential treatments, there are currently no approved methods to fully cure CMT, and existing options like rehabilitation and surgery only help manage symptoms.
- - The review focuses on the underlying causes of various CMT subtypes and explores promising therapies, particularly in gene therapy, with some approaches reaching clinical trial stages.
Non-coding RNAs in diabetic foot ulcer- a focus on infected wounds.
Diabetes Metab Res Rev
March 2024
Diabetes mellitus is associated with a wide range of neuropathies, vasculopathies, and immunopathies, resulting in many complications. More than 30% of diabetic patients risk developing diabetic foot ulcers (DFUs). Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play essential roles in various biological functions in the hyperglycaemic environment that determines the development of DFU.
View Article and Find Full Text PDFRepairing infected bone defects remains a challenge in clinical work. Intractable bacterial infections and insufficient osseointegration are major concerns for infected bone defects. To address these issues, we developed a gelatin methacryloyl (GelMA) and carboxymethyl chitosan (CMCS) composite hydrogel with BMP-2 growth factor and GO based antisense technology supported by a PLGA spring.
View Article and Find Full Text PDFDiabetic wounds, a prevalent chronic disease, are associated with older age. The hyperglycemic microenvironment in diabetic wounds significantly reduces the immune system, inducing bacterial invasion. The coupling of tissue repair and antibacterial treatment is critical for infected diabetic ulcer regeneration.
View Article and Find Full Text PDF[Effectiveness comparison of open reduction and internal fixation for open and closed ankle Logsplitter fractures].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
October 2018
Objective: To investigate the effectiveness of open reduction and internal fixation on high-energy ankle Logsplitter injuries (a kind of transsyndesmotic ankle fracture dislocation), and compare the prognosis between open and closed Logsplitter fracture.
Methods: The clinical data of 36 Logsplitter fractures treated with open reduction and internal fixation between April 2011 and May 2016 were retrospectively analyzed. Among them, 15 cases were open fracture and dislocation (open group) and 21 cases were closed fracture and dislocation (closed group).
[Biomechanical effect of anteromedial coronoid facet fracture and lateral collateral ligament complex injury on posteromedial rotational stability of elbow].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
February 2017
Objective: To investigate the effect of anteromedial coronoid facet fracture and lateral collateral ligament complex (LCLC) injury on the posteromedial rotational stability of the elbow joint.
Methods: The double elbows were obtained from 4 fresh adult male cadaveric specimens. Complete elbow joint (group A, =8), simple LCLC injury (group B, =4), simple anteromedial coronoid facet fracture (group C, =4), and LCLC injury combined with anteromedial coronoid facet fracture (group D, =8).